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New approach to control gastroenteritis viruses in wastewater reclamation and reuse by taking advantage of glycomics information

Research Project

Project/Area Number 26249075
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Civil and environmental engineering
Research InstitutionHokkaido University

Principal Investigator

Sano Daisuke  北海道大学, 工学研究院, 准教授 (80550368)

Co-Investigator(Kenkyū-buntansha) 大村 達夫  東北大学, 学内共同利用施設等, 教授 (30111248)
中込 治  長崎大学, 医歯(薬)学総合研究科, 教授 (70143047)
木村 克輝  北海道大学, 工学(系)研究科(研究院), 准教授 (10292054)
加藤 毅  群馬大学, その他部局等, 准教授 (40401236)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥41,860,000 (Direct Cost: ¥32,200,000、Indirect Cost: ¥9,660,000)
Fiscal Year 2016: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2015: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2014: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Keywords胃腸炎ウイルス / ノロウイルス / 糖鎖 / 相互作用 / ノロウイルス吸着性細菌 / 膜分離 / ロタウイルス / グライコミクス / レクチン / 下水処理水再生 / マイクロアレイ
Outline of Final Research Achievements

This study aims to find a new approach to control gastroenteritis viruses in wastewater treatment processes by taking advantage of glycan-recognition of viruses. Firstly, glycans that can be captured by norovirus particles were identified by glycan microarray. Based on the glycan microarray results, GD1a positive bacteria were isolated from environmental water samples. Microfiltration of norovirus in the presence of HBGA-positive bacteria was then performed. HBGA-producing genes were identified to track HBGA-positive bacteria in wastewater treatment processes. Finally, the removal of rotavirus HAL1166, which and recognize HBGA, with microfiltration membrane was investigated.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (35 results)

All 2016 2015 2014 Other

All Journal Article (11 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 7 results,  Acknowledgement Compliant: 5 results,  Open Access: 1 results) Presentation (23 results) (of which Int'l Joint Research: 5 results,  Invited: 3 results) Remarks (1 results)

  • [Journal Article] Bacterial histo-blood group antigens contributing to genotype-dependent removal of human noroviruses with a microfiltration membrane2016

    • Author(s)
      Mohan Amarasiri, Satoshi Hashiba, Takayuki Miura, Toyota Nakagomi, Osamu Nakagomi, Satoshi Ishii, Satoshi Okabe, Daisuke Sano
    • Journal Title

      Water Research

      Volume: 95 Pages: 383-391

    • DOI

      10.1016/j.watres.2016.04.018

    • NAID

      120006463555

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Genome sequence of Enterobacter cloacae strain SENG-6, a bacterium producing histo-blood group antigen-like substances that can bind with human noroviruses2016

    • Author(s)
      Satoshi Ishii, Amarasiri Mohan, Satoshi Hashiba, Peiyi Yang, Satoshi Okabe, Daisuke Sano
    • Journal Title

      Genome Announcements

      Volume: 4 Issue: 4

    • DOI

      10.1128/genomea.00893-16

    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] ノロウイルスの新知見2016

    • Author(s)
      門屋俊介、伊藤寿宏、佐野大輔
    • Journal Title

      膜協会ジャーナル

      Volume: 23 Pages: 7-15

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 下水再生処理におけるヒト腸管系ウイルスの目標除去率の算定法2016

    • Author(s)
      伊藤寿宏、押木守、小林直央、加藤毅、瀬川高弘、幡本将史、山口隆司、原田秀樹、北島正章、岡部聡、佐野大輔
    • Journal Title

      土木学会論文集

      Volume: 72 Pages: 305-313

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Evaluation of virus removal efficiency in unit processes directly applicable to multiple-barrier system for wastewater reclamation2016

    • Author(s)
      Toshihiro Ito, Tsuyoshi Kato, Makoto Hasegawa, Hiroyuki Katayama, Satoshi Ishii, Satoshi Okabe, Daisuke Sano
    • Journal Title

      Journal of Water and Health

      Volume: 14 Issue: 6 Pages: 879-889

    • DOI

      10.2166/wh.2016.096

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 環境と胃腸炎ウイルス:ウイルス吸着性細菌との関わり2016

    • Author(s)
      佐野大輔
    • Journal Title

      ウイルス

      Volume: 66 Pages: 179-186

    • NAID

      130006183772

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Evaluation of concentrations of pharmaceuticals detected in sewage influents in Japan by using annual shipping and sales data2015

    • Author(s)
      Azuma, T., Nakada, N., Yamashita, N., Tanaka, H.
    • Journal Title

      Chemosphere

      Volume: 138 Pages: 770-776

    • DOI

      10.1016/j.envint.2016.03.001

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Removal properties of human enteric viruses in a pilot-scale membrane bioreactor (MBR) process2015

    • Author(s)
      Takayuki Miura, Satoshi Okabe, Yoshihito Nakahara, Daisuke Sano
    • Journal Title

      Water Research

      Volume: 75 Pages: 282-291

    • DOI

      10.1016/j.watres.2015.02.046

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 将来の社会システムにおける感染性胃腸炎リスク2015

    • Author(s)
      佐野大輔
    • Journal Title

      最新医学

      Volume: 70 Pages: 2415-2422

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Bayesian modeling of virus removal efficiency in wastewater treatment processes2015

    • Author(s)
      Toshihiro Ito, Tsuyoshi Kato, Kento Takagishi, Satoshi Okabe, Daisuke Sano
    • Journal Title

      Water Science and Technology

      Volume: 72 Issue: 10 Pages: 1789-1795

    • DOI

      10.2166/wst.2015.402

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Microfluidic quantitative PCR for simultaneous quantification of multiple viruses in environmental water samples2014

    • Author(s)
      Satoshi Ishii, Gaku Kitamura, Ayano Kobayashi, Takayuki Miura, Daisuke Sano, Satoshi Okabe
    • Journal Title

      Applied and Environmental Microbiology

      Volume: 80(24) Issue: 24 Pages: 7505-7511

    • DOI

      10.1128/aem.02578-14

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] 血液型決定抗原陽性細菌と胃腸炎ウイルス2016

    • Author(s)
      佐野大輔
    • Organizer
      第3回札幌微生物研究者合同セミナー
    • Place of Presentation
      北海道大学農学部食資源棟セミナールーム(札幌市)
    • Year and Date
      2016-12-12
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 下水再生処理におけるヒト腸管系ウイルスの目標除去効率の算定法2016

    • Author(s)
      伊藤寿宏, 押木守, 小林直央, 加藤毅, 瀬川高弘, 幡本将史, 山口隆司, 原田秀樹, 北島正章, 岡部聡, 佐野大輔
    • Organizer
      第53回環境工学研究フォーラム
    • Place of Presentation
      北九州国際会議場(北九州市)
    • Year and Date
      2016-12-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] Human glycan-positive bacteria as an adsorbent for norovirus2016

    • Author(s)
      Mohan Amarasiri, Satoshi Hashiba, Satoshi Okabe, Tatsuya Miyoshi, Tomoyuki Tanaka, Daisuke Sano
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      札幌市コンベンションセンター(札幌市)
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Diversity of histo-blood group antigen-positive bacteria as a specific adsorbent for human noroviruses2016

    • Author(s)
      Daisuke Sano, Mohan Amarasiri, Satoshi Hashiba, Takatomo Ohta, Takayuki Miura, Toyoko Nakagomi, Osamu Nakagomi and Satoshi Okabe
    • Organizer
      6th International Calicivirus Conference
    • Place of Presentation
      Hyatt Regency (Savannah, USA)
    • Year and Date
      2016-10-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A systematic review and meta-analysis on the virus removal efficiencies of wastewater treatment plant unit processes2016

    • Author(s)
      Mohan Amarasiri, Daisuke Sano, Akihiko Hata, Toru Watanabe and Hiroyuki Katayama
    • Organizer
      5th Food and Environmental Virology Conference
    • Place of Presentation
      ホテル櫻井(草津町)
    • Year and Date
      2016-09-13
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Log reduction of norovirus required in wastewater reclamation2016

    • Author(s)
      Toshihiro Ito, Tsuyoshi Kato, Satoshi Ishii, Takahiro Segawa, Masaaki Kitajima, Satoshi Okabe, Daisuke Sano
    • Organizer
      5th Food and Environmental Virology Conference
    • Place of Presentation
      ホテル櫻井(草津町)
    • Year and Date
      2016-09-13
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヒトノロウイルス吸着性細菌の単離に関する研究2016

    • Author(s)
      佐野大輔、羽柴聡、岡部聡
    • Organizer
      日本ウイルス学会北海道支部・第50回夏季シンポジウム
    • Place of Presentation
      北海道青少年会館コンパス(札幌市)
    • Year and Date
      2016-07-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Genotype dependent norovirus removal by microfiltration: Influence of bacterial histo-blood group antigens2016

    • Author(s)
      Mohan Amarasiri, Satoshi Hashiba, Satoshi Okabe, Daisuke Sano
    • Organizer
      第3回環境水質工学シンポジウム
    • Place of Presentation
      愛媛大学(松山市)
    • Year and Date
      2016-05-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] 共存細菌との結合が胃腸炎ウイルスの消毒効果に与える影響2016

    • Author(s)
      林祥一
    • Organizer
      第50回日本水環境学会年会
    • Place of Presentation
      アスティとくしま(徳島県徳島市)
    • Year and Date
      2016-03-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 糖鎖認識プロファイル情報をもとにしたヒトノロウイルス吸着性細菌の単離に関する研究2016

    • Author(s)
      羽柴聡
    • Organizer
      第50回日本水環境学会年会
    • Place of Presentation
      アスティとくしま(徳島県徳島市)
    • Year and Date
      2016-03-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] DHS(Downflow Hanging Sponge)リアクターにおける病原ウイルスの除去効率2016

    • Author(s)
      小林直央
    • Organizer
      第50回日本水環境学会年会
    • Place of Presentation
      アスティとくしま(徳島県徳島市)
    • Year and Date
      2016-03-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] Diverse enteric bacteria can excrete histo-blood group antigens as adsorbents for human gastroenteritis viruses2015

    • Author(s)
      佐野大輔
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 下水中からのノロウイルス吸着性腸内細菌単離手法の確立2015

    • Author(s)
      羽柴聡
    • Organizer
      第23回衛生工学シンポジウム
    • Place of Presentation
      北海道大学・フロンティア応用科学研究棟(北海道札幌市)
    • Year and Date
      2015-11-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] Estimation of pathogen density distribution in water based on left-cencored dataset: Bayesian vs Maximum a posteriori2015

    • Author(s)
      Daisuke Sano
    • Organizer
      International Environmental Engineering Conference 2015
    • Place of Presentation
      BEXCO(Busan, Korea)
    • Year and Date
      2015-10-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Diversity of histo-blood group antigen-positive enteric bacteria in water: Possible environmental vehicle for human noroviruses2015

    • Author(s)
      Daisuke Sano
    • Organizer
      18th International Symposium on Health-Related Water Microbiology
    • Place of Presentation
      リスボン大学(Lisbon, Portugal)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 下水中からのHBGA陽性細菌の単離2015

    • Author(s)
      佐野大輔
    • Organizer
      第2回環境水質工学シンポジウム
    • Place of Presentation
      山形大学農学部(山形県鶴岡市)
    • Year and Date
      2015-05-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 胃腸炎ウイルスの感染制御に関する研究2015

    • Author(s)
      佐野大輔
    • Organizer
      第3回水環境科学・技術研修会
    • Place of Presentation
      高知大学農学部(高知県高知市)
    • Year and Date
      2015-04-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 下水からのノロウイルス吸着性腸内細菌の単離に関する研究2015

    • Author(s)
      太田崇智、岡部聡、中込とよ子、中込治、佐野大輔
    • Organizer
      第49回日本水環境学会年会
    • Place of Presentation
      金沢大学
    • Year and Date
      2015-03-16 – 2015-03-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 胃腸炎ウイルスと血液型決定抗原2015

    • Author(s)
      佐野大輔
    • Organizer
      第49回日本水環境学会年会・水中健康関連微生物研究委員会
    • Place of Presentation
      金沢大学
    • Year and Date
      2015-03-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] 胃腸炎ウイルスの感染制御因子2015

    • Author(s)
      佐野大輔
    • Organizer
      第11回小児消化管感染症研究会
    • Place of Presentation
      大阪大学中之島センター
    • Year and Date
      2015-02-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Genotype-dependent membrane separation of human noroviruses with bacterial histo-blood group antigen-like substances2014

    • Author(s)
      Mohan Amarasiri, Takeshi Yoshimura, Toyoko Nakagomi, Osamu Nakagomi, Satoshi Okabe and Daisuke Sano
    • Organizer
      4th Food and Environmental Virology Conference
    • Place of Presentation
      Ionian Academy, Corfu town, Greece
    • Year and Date
      2014-09-02 – 2014-09-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Membrane separation of human noroviruses in combination with enteric bacteria bearing histo-blood group antigen (HBGA)-like substances2014

    • Author(s)
      Mohan Amarasiri, Takeshi Yoshimura, Satoshi Okabe, Daisuke Sano
    • Organizer
      IWA Particle Separation Conference
    • Place of Presentation
      北海道大学・学術交流会館
    • Year and Date
      2014-06-15 – 2014-06-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Norovirus removal with microfiltration in the presence of HBGA-like substances-bearing bacteria: A new approach to improve removal efficiency2014

    • Author(s)
      Mohan Amarasiri, Takeshi Yoshimura, Toyoko Nakagomi, Osamu Nakagomi, Satoshi Okabe, Daisuke Sano
    • Organizer
      第1回環境水質工学シンポジウム
    • Place of Presentation
      東北大学・青葉記念会館
    • Year and Date
      2014-05-09
    • Related Report
      2014 Annual Research Report
  • [Remarks] 北海道大学・水質変換工学研究室

    • URL

      http://www.eng.hokudai.ac.jp/labo/water/index.html

    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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