| Project/Area Number |
26249111
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Material processing/Microstructural control engineering
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
土谷 博昭 大阪大学, 工学(系)研究科(研究院), 准教授 (50432513)
末廣 さやか (宮部 / 宮部 さやか) 大阪大学, 工学(系)研究科(研究院), 助教 (50584132)
廣本 祥子 国立研究開発法人物質・材料研究機構, その他部局等, その他 (00343880)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥41,340,000 (Direct Cost: ¥31,800,000、Indirect Cost: ¥9,540,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2014: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
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| Keywords | 電気化学プロセス / 生体材料 / 再不働態化 / 生体親和性 / 表面改質 / ナノ構造 / 細胞培養 |
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| Outline of Final Research Achievements |
The present work achieved the evaluation of long-term reliability of metallic biomaterials in simulated body fluids. In order to perform long-term experiments without any degradations of medium, a new experimental setup was developed. As a result, cyclic deformation tests could be carried out up to 2 weeks without the degradation. The results obtained in the tests revealed that the presence of proteins and cells on metallic biomaterials suppressed the metal dissolution during deformation on one hand, but the repassivaiton was hampered by proteins and cells on the other hand. Furthermore, proteins and cells affected not only the metal dissolution and repassivation during deformation but also resulting crack initiation and propagation. Surface modification could suppress the degradation caused by deformation. It was also found that in a current-controlled polarization experiment, the composition and structure of passive films strongly affected cathodic reaction.
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