| Budget Amount *help |
¥39,910,000 (Direct Cost: ¥30,700,000、Indirect Cost: ¥9,210,000)
Fiscal Year 2017: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2016: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2015: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2014: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
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| Outline of Final Research Achievements |
We devised and improved the optical system, which now allows us to image over 300 spines at a high speed of 100 Hz. Using this new technology:
i) we captured dendritic computations of pyramidal cells of the Hippocampal CA3 field. Large-scale analyses of the dendritic computations in terms of the circuit operation principle revealed that the balance between excitatory and inhitibory inputs collapsed locally. We published these results in Cell Reports.
ii) Hippocampal CA1 neurons that had been activated by environmental exploration were reactivated by specific synchronous inputs from precisely woven neuronal circuits in the upstream CA3 field. Using optical time-lapse imaging of dendrites, we discovered that the precision of cells to be activated gradually increases by repeating the synchronous activity itself. We published these results in Science.
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