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Functional division and interaction among prefrontal cortical areas

Research Project

Project/Area Number 26250011
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Tanaka Keiji  国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (00221391)

Co-Investigator(Renkei-kenkyūsha) HIGO TAKAYASU  国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 (10396757)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥39,780,000 (Direct Cost: ¥30,600,000、Indirect Cost: ¥9,180,000)
Fiscal Year 2016: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2015: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2014: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Keywords認知制御 / 執行機能 / ウィスコンシンカード分類課題 / 前帯状溝皮質 / 主溝皮質 / 尾状核 / 前頭前野 / 領野間相互作用 / 尾状核頭部 / 同期活動 / 機能分化 / 投射特異的機能ブロック / 目的指向的行動 / 領野間相互佐用
Outline of Final Research Achievements

To uncover the functional interaction between prefrontal cortical areas, we have conducted simultaneous local-field-potential recordings from the monkeys performing a cognitively demanding task with frequent rule switches. We have also developed a projection-specific functional blockage method with virus vectors. In the recording experiments, the anterior cingulate sulcus area, principal sulcus area, and caudate head increased the power of activities in low-beta frequency band (~15Hz) at the initial fixation period of each trial and at the inter-trial interval, and these activities in the three regions were synchronized. The transient increase of the synchronized activities suggests that the three regions exchanged signals specifically in these time epochs.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (13 results)

All 2017 2016 2015 2014

All Journal Article (8 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 8 results,  Open Access: 5 results,  Acknowledgement Compliant: 3 results) Presentation (5 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Neural representation for object recognition in inferotemporal cortex.2016

    • Author(s)
      Lehky SR, Tanaka K
    • Journal Title

      Curr. Opinion Neurobiol.

      Volume: in press Pages: 23-35

    • DOI

      10.1016/j.conb.2015.12.001

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The neural system of postdecision evaluation in rostral frontal cortex during problem-solving tasks.2016

    • Author(s)
      Wan X, Cheng K, Tanaka K.
    • Journal Title

      eNeuro

      Volume: 3 Issue: 4 Pages: 1-24

    • DOI

      10.1523/eneuro.0188-16.2016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Behavioral consequences of selective damage to frontal pole and posterior cingulate cortices.2015

    • Author(s)
      Mansouri FA, Buckley MJ, Mahboubi M, Tanaka K
    • Journal Title

      Proc. Natl. Acad. Sci. U. S. A.

      Volume: 112 Issue: 29

    • DOI

      10.1073/pnas.1422629112

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Time context of cue-outcome associations represented by neurons in perirhinal cortex2015

    • Author(s)
      Eradath MK, Mogami T, Wang G, Tanaka K
    • Journal Title

      J. Neurosci.

      Volume: 35 Issue: 10 Pages: 4350-4350

    • DOI

      10.1523/jneurosci.4730-14.2015

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cognitive control functions of anterior cingulate cortex in macaque monkeys performing a Wisconsin Card Sorting Test analog2014

    • Author(s)
      Kuwabara M, Mansouri FA, Buckley MJ, Tanaka K
    • Journal Title

      J. Neurosci.

      Volume: 34 Issue: 22 Pages: 7531-7531

    • DOI

      10.1523/jneurosci.3405-13.2014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dimensionality of object representations in monkey inferotemporal cortexNeural Computatio2014

    • Author(s)
      Lehky SR, Roozbeh K, Esteky H, Tanaka K
    • Journal Title

      Neural Computatio

      Volume: 26 Issue: 10 Pages: 2135-2135

    • DOI

      10.1162/neco_a_00648

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neural substrates of view-invariant object recognition developed without experiencing rotations of the objects2014

    • Author(s)
      Okamura J., Yamaguchi R., Honda K., Wang G., Tanaka K
    • Journal Title

      The Journal of Neuroscience

      Volume: 34 Issue: 45 Pages: 15047-15059

    • DOI

      10.1523/jneurosci.1898-14.2014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The essential role of primate orbitofrontal cortex in conflict-induced executive control adjustment2014

    • Author(s)
      Mansouri FA, Buckley MJ, Tanaka K
    • Journal Title

      J. Neurosci.

      Volume: 34 Issue: 33 Pages: 11016-11016

    • DOI

      10.1523/jneurosci.1637-14.2014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Changes in deoxygenation level of bloods and cortical tissues following neuronal activity changes as the bases for intrinsic optical recordings and fMRI2017

    • Author(s)
      Tanaka K
    • Organizer
      国際シンポジウム「脳科学の未来」
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2017-03-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The role of frontal pole cortex in primate goal-directed behaviour2016

    • Author(s)
      Mansouri FA, Tanaka K
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] Synchronous beta oscillations in the fronto-striatal loop for behavioral rule switching in macaque monkeys2016

    • Author(s)
      Gerard-Mercier F, Tanaka K
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] Columnar scale representation of faces in the human inferotemporal cortex2016

    • Author(s)
      Tanskanen T, Kao CH, Waggoner RA, Ueno K, Tanaka K, Cheng K
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] Enhancement of event-related fMRI studies of the human visual system using multi-band EPI2016

    • Author(s)
      Waggoner RA, Tanskanen T, Tanaka K, Cheng K
    • Organizer
      24th Annual Meeting and Exhibition of International Society for Magnetic Resonance in Medicine
    • Place of Presentation
      Singapore, Singapore
    • Year and Date
      2016-05-10
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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