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Function of spinal neuronal system for controlling voluntary movement

Research Project

Project/Area Number 26250013
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

SEKI Kazuhiko  国立研究開発法人国立精神・神経医療研究センター, 神経研究所 モデル動物開発研究部, 部長 (00226630)

Co-Investigator(Kenkyū-buntansha) 太田 淳  奈良先端科学技術大学院大学, 先端科学技術研究科, 教授 (80304161)
Project Period (FY) 2014-06-27 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥39,910,000 (Direct Cost: ¥30,700,000、Indirect Cost: ¥9,210,000)
Fiscal Year 2017: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2016: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2015: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2014: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Keywords脊髄介在ニューロン / ミラーニューロン / 筋シナジー / シナプス前抑制 / 光遺伝学 / 脊髄 / サル / 感覚フィードバック
Outline of Final Research Achievements

【Research item 1】 Muscle synergy expressed by cerebral cortex primary motor cortex and rubrospinal pathway cells was clarified. The results found that the contribution to cortical areas and cell muscle activity generation was not uniform. 【Research item 2】 Of the primary somatosensory area, significant mirror-neuron-like activity was observed in Area 3a, whereas neuronal activity was not recorded in Area 3b. Mirror activity seen in the cortex may reflect self and the other's musculoskeletal movement itself. 【Research item 3】We found that presynaptic inhibition during exercise was selectively occurred depending on sensory type and exercise content. We also developed a new method to intervene in peripheral nerve activity by light genetics.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (53 results)

All 2018 2017 2016 2015 2014 Other

All Int'l Joint Research (4 results) Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Open Access: 5 results,  Acknowledgement Compliant: 3 results) Presentation (35 results) (of which Int'l Joint Research: 7 results,  Invited: 14 results) Book (7 results)

  • [Int'l Joint Research] University Collage London(英国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University College London(英国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Arizona University(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Ferara University/Institute of Fondazione Santa Lucia/Institute in Padova(イタリア)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Neural basis for hand muscle synergies in the primate spinal cord.2017

    • Author(s)
      Takei T, Confais J, Tomatsu S, Oya T, Seki K
    • Journal Title

      Proc Natl Acad Sci

      Volume: 114 (32) Issue: 32 Pages: 8643-8648

    • DOI

      10.1073/pnas.1704328114

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nerve-specific input modulation to spinal neurons during a motor task in the monkey2017

    • Author(s)
      Confais J, Kim G, Tomatsu S, Takei T, Seki K.
    • Journal Title

      J. Neurosci.

      Volume: 37 (10) Issue: 10 Pages: 2561-16

    • DOI

      10.1523/jneurosci.2561-16.2017

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Muscle afferent excitability testing in spinal root-intact rats: Dissociating peripheral afferent and efferent volleys generated by intraspinal microstimulation.2017

    • Author(s)
      Tomatsu S, Kim G, Confais J, Seki K
    • Journal Title

      J. Neurophysiol.

      Volume: 117 (2) Issue: 2 Pages: 796-807

    • DOI

      10.1152/jn.00874.2016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Representation of afferent signals from forearm muscle and cutaneous nerves in the primary somatosensory cortex of the macaque monkey2016

    • Author(s)
      Hiroshi Yamada, Hiroaki Yaguchi, Saeka Tomatsu, Tomohiko Takei, Tomomichi Oya, Kazuhiko Seki
    • Journal Title

      PLOS ONE

      Volume: 11 (10) Issue: 10 Pages: e0163948-e0163948

    • DOI

      10.1371/journal.pone.0163948

    • NAID

      120007129308

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Modulation of spinal motor output by initial arm postures in anesthetized Monkeys.2015

    • Author(s)
      Kazuhiko Seki, Hiroaki Yaguchi, Tomohiko Takei, David Kowalski, Takafumi Suzuki and Kunihiko Mabuchi
    • Journal Title

      The Journal of Neuroscience

      Volume: 35(17) Issue: 17 Pages: 6937-6945

    • DOI

      10.1523/jneurosci.3846-14.2015

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Internal capsule stroke in the common marmoset2015

    • Author(s)
      Puentes S, Seki K.
    • Journal Title

      Neuroscience

      Volume: 284 Pages: 400-411

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 中脳赤核と運動機能―系統発生的観点から―Red Nucleus and Its Motor Function –A Phylogenetic Perspective–2014

    • Author(s)
      大屋知徹・関和彦
    • Journal Title

      Spinal Surgery

      Volume: 28(3) Pages: 258-263

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 筋再配置手術が生み出す3つのSlow Dynamics.2018

    • Author(s)
      関和彦
    • Organizer
      第6回身体性システム領域全体会議
    • Related Report
      2017 Annual Research Report
  • [Presentation] Sensory gating during voluntary movement: neural correlates in the cortical and subcortical network2017

    • Author(s)
      関和彦
    • Organizer
      7th CiNet Monthly Seminar
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Contrasted coherent oscillations to muscular activity in the monkey spinal cord and motor cortex during a precision grip task.2017

    • Author(s)
      大屋知徹, 武井智彦, 関和彦
    • Organizer
      第11回Motor Control研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 筋シナジーの神経表現2017

    • Author(s)
      関和彦, 武井智彦,  Joachim Confais, 大屋知徹, 戸松彩花
    • Organizer
      第11回Motor Control研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Sensory gating during volitional movements: neuronal correlates at the cortical and subcortcal levels2017

    • Author(s)
      Seki K
    • Organizer
      JSPS2国間セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 協調運動の神経表現:基礎から臨床まで Neural basis for spatiotemporal coordination of muscle activity.2017

    • Author(s)
      関和彦
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Sensory gating and presynaptic inhibition during voluntary movement.2017

    • Author(s)
      Seki K
    • Organizer
      Neural Control of Movement 2017
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Presynaptic inhibition of muscle afferent input to spinal cord in awake, behaving monkeys.2017

    • Author(s)
      Tomatsu S, Kim G, Kubota S, Seki K
    • Organizer
      SfN’s 47th annual meeting
    • Related Report
      2017 Annual Research Report
  • [Presentation] Voluntary movement and spinal interneuronal circuit : non-human primate study2016

    • Author(s)
      Seki K
    • Organizer
      Australasian Neuroscience Society Annual Scientific Meeting 2016
    • Place of Presentation
      Hotel Grand Chancellor, Hobart, Australia
    • Year and Date
      2016-12-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functional tuning of rubromotoneuronal cells in the forelimb movement in a macaque monkey2016

    • Author(s)
      Tomomichi Oya, Tomohiko Takei, Kazuhiko Seki
    • Organizer
      Neuroscience 2016
    • Place of Presentation
      San Diego Convention Center, USA
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Exploring a neural correlate of muscle synergy for hand and arm movement2016

    • Author(s)
      Seki K, Takei T, Oya T, Confais J, Philipp R
    • Organizer
      38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Disney's Contemporary Resort, Orland, Florida, USA
    • Year and Date
      2016-08-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In vivo electrophysiological evaluation of Chanelrhodopsin-2-expressed dorsal root ganglion neurons in adult rats.2016

    • Author(s)
      Kazuhiko Seki, Sidikejiang Wupuer, Tatsuya Umeda, Ken-Ichi Inoue, Moeko Kudo, Masahiko Takada
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-07-22
    • Related Report
      2016 Annual Research Report
  • [Presentation] Differential adeno-associated virus mediated gene transfer to dorsal root ganglion neurons with different size in common marmosets2016

    • Author(s)
      Moeko Kudo,Sidikejiang Wupuer, Ken-Ichi Inoue, Masahiko Takada, Kazuhiko Seki
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-07-22
    • Related Report
      2016 Annual Research Report
  • [Presentation] Neural adaptation in response to change in the musculoskeletal system: A new primate model2016

    • Author(s)
      Roland Philipp, Joachim Confais, Tomomichi Oya, Kazuhiko Seki
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-07-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] Comparison of muscle synergies calculated in different motor contexts2016

    • Author(s)
      Joachim Confais, Tomomichi Oya, Kazuhiko Seki
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-07-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] Exploring a neural correlate of muscle synergy in the spinal cord2016

    • Author(s)
      Seki K
    • Organizer
      Embodied-Brain: Perspectives from Motor Control and Muscle Synergies
    • Place of Presentation
      Hotel Villa Diodoro, Taormina, Italy
    • Year and Date
      2016-05-31
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Non-human primate research for elucidating sensorimotor function2016

    • Author(s)
      Kazuhiko Seki
    • Organizer
      University Collage of London Seminar
    • Place of Presentation
      University Collage of London FIL Seminar Room
    • Year and Date
      2016-04-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 神経科学はスポーツパフォーマンス向上に貢献できるか2016

    • Author(s)
      関和彦
    • Organizer
      スポーツ脳科学セミナー
    • Place of Presentation
      キロロトリビュートポートフォリオホテル北海道
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 中枢神経系における身体表現と認知-運動連関の機能構築・再構築2016

    • Author(s)
      関和彦(オーガナイザー)
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2016-03-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 多領域連関による感覚運動変換メカニズムとその病態2016

    • Author(s)
      関和彦
    • Organizer
      平成27年度京都大学霊長類研究所共同利用研究会「霊長類脳科学の新しい展開とゲノム科学との融合」
    • Place of Presentation
      京都大学霊長類研究所大会議室
    • Year and Date
      2016-03-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ニューオーリンズのカフェにて2015

    • Author(s)
      関和彦
    • Organizer
      生理研研究会「行動システム脳科学の新展開」
    • Place of Presentation
      生理研研究所1階大会議室
    • Year and Date
      2015-12-04
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 神経投射に関する講演2015

    • Author(s)
      関 和彦
    • Organizer
      神経投射に関するセミナー
    • Place of Presentation
      東大本郷キャンパス工学部2号館3階232号講義室
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 運動と感覚の基礎 神経生理に基づくリハビリテーションに向けて2015

    • Author(s)
      関和彦
    • Organizer
      第96回ロボット工学セミナー
    • Place of Presentation
      名古屋大学東山キャンパス VBLホール
    • Year and Date
      2015-11-17
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 神経回路への理解がもたらすリハの革新2015

    • Author(s)
      関和彦
    • Organizer
      第1回身体性システム公開シンポジウム 身体性システム科学が拓くリハビリテーションの未来
    • Place of Presentation
      東京大学武田先端知ビル武田ホール
    • Year and Date
      2015-10-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Differential modulation of sensory input from three forearm afferent nerves to the spinal cord of monkeys during delayed wrist movements2015

    • Author(s)
      Joachim Confais, Jihee Kim, Saeka Tomatsu, Tomohiko Takei, Kazuhiko Seki
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Chicago, US McCormick Place
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Restoring human hand function: Insights from neurophysiology and biomechanical study of non-human primates2015

    • Author(s)
      Kazuhiko Seki
    • Organizer
      SBHSE Seminar
    • Place of Presentation
      Arizona University SCOB210
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Muscle synergy as a foundation of embodied brain2015

    • Author(s)
      Kazuhiko Seki
    • Organizer
      IEEE/RSJ International Conference on Intelligent Robots and Systems
    • Place of Presentation
      Congress Center Hamburg (CCH)
    • Year and Date
      2015-09-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Embodied-Brain Systems Sciences2015

    • Author(s)
      Kazuhiko Seki
    • Organizer
      37TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Milan, Itary Milano Conference Center
    • Year and Date
      2015-08-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 感覚運動系の学習・可塑性2015

    • Author(s)
      関和彦(座長)
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 運動駆動細胞群の筋シナジー創出機構2015

    • Author(s)
      大屋知徹、武井智彦、関和彦
    • Organizer
      平成26年度生理学研究所研究会「行動システム脳科学の新展開」
    • Place of Presentation
      生理学研究所
    • Year and Date
      2015-01-09 – 2015-01-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] Subcortical control of voluntary movement2014

    • Author(s)
      K. Seki
    • Organizer
      18th Thai Neuroscience Society Conference 2014 and 2 nd CU-NIPS Symposium “Frontier in Neuroscience Research”
    • Place of Presentation
      Chulalongkorn University, Bangkok, Thailand
    • Year and Date
      2014-12-22 – 2014-12-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Posture dependency of the twitch responses induced by intraspinal microstimulation to the primate spinal cord2014

    • Author(s)
      H. Yaguchi, D. Kowalski, T. Takei and K. Seki
    • Organizer
      Society for Neuroscience2014
    • Place of Presentation
      Walter E. Washington Convention Center, Washington D.C., U.S.
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 3次元筋骨格モデルに基づくニホンザル精密把握動作の逆動力学解析, Inverse dynamic analysis of precision grip in the Japanese macaque based on a three-dimensional musculoskeletal model.2014

    • Author(s)
      荻原直道、斉藤剛、武井智彦、関和彦
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 異なる下行路系から生み出される筋投射構造と筋シナジーへの収斂2014

    • Author(s)
      大屋知徹、武井智彦、関和彦
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 赤核の回路と機能における推察2014

    • Author(s)
      大屋知徹, 武井智彦, 関和彦
    • Organizer
      第8回Motor Control研究会
    • Place of Presentation
      つくば大学
    • Year and Date
      2014-08-07 – 2014-08-09
    • Related Report
      2014 Annual Research Report
  • [Book] 手の百科事典2017

    • Author(s)
      関和彦ほか99名
    • Total Pages
      608
    • Publisher
      朝倉書店
    • Related Report
      2017 Annual Research Report
  • [Book] 体性感覚と手の運動. Clinical Neuroscience2017

    • Author(s)
      関和彦
    • Total Pages
      120
    • Publisher
      中外医学社
    • Related Report
      2016 Annual Research Report
  • [Book] 手と脊髄. 25年の歩み2016

    • Author(s)
      関和彦
    • Total Pages
      354
    • Publisher
      株式会社中山書店
    • Related Report
      2016 Annual Research Report
  • [Book] バイオメカニズム学会誌2015

    • Author(s)
      関和彦
    • Total Pages
      6
    • Publisher
      バイオメカニズム学会
    • Related Report
      2015 Annual Research Report
  • [Book] 神経科学の最前線とリハビリテーション-脳の可塑性と運動-2015

    • Author(s)
      関和彦
    • Total Pages
      7
    • Publisher
      医師薬出版株式会社
    • Related Report
      2015 Annual Research Report
  • [Book] システム/制御/情報 : システム制御情報学会誌 「神経データの信号解析」特集号2015

    • Author(s)
      関和彦
    • Total Pages
      6
    • Publisher
      システム制御情報学会
    • Related Report
      2015 Annual Research Report
  • [Book] 脳神経外科診療プラクティス 6 脳神経外科医が知っておくべきニューロサイエンスの知識2015

    • Author(s)
      関和彦
    • Total Pages
      16
    • Publisher
      文光堂
    • Related Report
      2015 Annual Research Report

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Published: 2014-11-20   Modified: 2019-03-29  

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