An establishment of mouse phenotyping system for verification of the neurobiological infrastructure on the psychiatric disorders

• Project/Area Number: 26250024
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Laboratory animal science
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Wakana Shigeharu 国立研究開発法人理化学研究所, バイオリソースセンター, チームリーダー (90192434)
• Co-Investigator(Kenkyū-buntansha): 掛山 正心 早稲田大学, 人間科学学術院, 教授 (30353535) ; 古市 貞一 東京理科大学, 理工学部, 教授 (50219094) ; 山末 英典 東京大学, 医学部附属病院, 准教授 (80436493)
• Co-Investigator(Renkei-kenkyūsha): MASUYA Hiroshi 国立研究開発法人理化学研究所, バイオリソースセンター, ユニットリーダー (40321814)
• Project Period (FY): 2014-06-27 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥40,430,000 (Direct Cost: ¥31,100,000、Indirect Cost: ¥9,330,000); Fiscal Year 2016: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000); Fiscal Year 2015: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000); Fiscal Year 2014: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
• Keywords: 発達障害 / モデルマウス / 精神疾患 / 表現型解析プラットフォーム / 自閉症スペクトラム / 社会的競争環境テスト / マウス / 表現型解析 / 自閉症 / 社会性行動 / 社会行動 / モデル動物 / 行動表現型解析 / 自閉症スペクトラム障害

Outline of Final Research Achievements

Wakana group established the mouse behavior phenotyping platform on focusing developmental disorder based on several dimensional symptom. They performed the tests in 19 KO mouse lines and characterized the abnormal parameters using R statistic method. Kakeyama group examined the behavioral characteristics under group-housed condition of the Grin 1 mouse. The test paradigm can be an effective analysis system for behavioral abnormality of developmental disorder-like symptom. Furuichi group showed the up regulation of synaptic vesicle exocytosis related genes Stx5a and Syt6 and the down-regulation of MeCP2 gene and Oxtr gene in CAPS2 KO mouse brains by microarray analysis. Yamasue group identified dysfunctions in social cognition and brain regions as the background of deficits in social communication in individuals with ASD in man. They showed effects of intranasal oxytocin on these dysfunctions and their associations with the SNPs in oxytocin related genes.

Research Products

• [Journal Article] A spontaneous and novel Pax3 mutant mouse that models Waardenburg syndrome and neural tube defects (2017)
  • Author(s): Ohnishi T, Miura I, Ohba H, Shimamoto C, Iwayama Y, Wakana S, Yoshikawa T.
  • Journal Title: Gene Volume: 607 Pages: 16-22
  • DOI: 10.1016/j.gene.2016.12.037
  • Peer Reviewed
• [Journal Article] Protein-restricted diet during pregnancy after insemination alters behavioral phenotypes of the progeny (2017)
  • Author(s): Furuse T, Miyake K, Kohda T, Kaneda H, Hirasawa T, Yamada I, Kushida T, Kashimura M, Kobayashi K, Ishino F, Kubota T, Wakana S.
  • Journal Title: Genes & Nutrition Volume: 12 Issue: 1 Pages: 1-1
  • DOI: 10.1186/s12263-016-0550-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Oxytocin receptor gene variations predict neural and behavioral response to oxytocin in autism (2017)
  • Author(s): Watanabe T, Otowa T, Abe O, Kuwabara H, Aoki Y, Natsubori T, Takao H, Kakiuchi C, Kondo K, Ikeda M, Iwata N, Kasai K, Sasaki T, Yamasue H.
  • Journal Title: Social Cognitive and Affective Neuroscience Volume: 12 Issue: 3 Pages: 496-506
  • DOI: 10.1093/scan/nsw150
  • Peer Reviewed
• [Journal Article] Severe ocular phenotypes in Rbp4-deficient mice in the C57BL/6 genetic background. (2016)
  • Author(s): Shen, J., Shi, D., Suzuki, T., Xia, Z., Zhang, H., Araki, K., Wakana, S., Takeda, N., Yamamura, K., Jin, S. and Li. Z.
  • Journal Title: Lab. Invest. Volume: in press Issue: 6 Pages: 1-12
  • DOI: 10.1038/labinvest.2016.39
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Hyperactivation of JAK1 tyrosine kinase induces stepwise, progressive pruritic dermatitis (2016)
  • Author(s): Yasuda T, Fukada T, Nishida K, Nakayama M, Matsuda M, Miura I, Dainichi T, Fukuda S, Kabashima K, Nakaoka S, Bin BH, Kubo M, Ohno H, Hasegawa T, Ohara O, Koseki H, Wakana S, Yoshida H
  • Journal Title: J. Clin. Invest Volume: 126(6) Issue: 6 Pages: 2064-76
  • DOI: 10.1172/jci82887
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] ATF7 ablation prevents diet-induced obesity and insulin resistance. (2016)
  • Author(s): Liu Y et al.
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 478 Issue: 2 Pages: 696-702
  • DOI: 10.1016/j.bbrc.2016.08.009
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Identification of mutations through dominant screening for obesity using C57BL/6 substrains (2016)
  • Author(s): Hossain MS., Funato H, and Yanagisawa M et al.
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 32453-32453
  • DOI: 10.1038/srep32453
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] High-throughput discovery of novel developmental phenotypes (2016)
  • Author(s): Dickinson ME, Tamura M, Wakana S, Yoshiki A, Brown SD, M, Murray SA. et al.
  • Journal Title: Nature Volume: 537 Issue: 7621 Pages: 508-514
  • DOI: 10.1038/nature19356
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Forward-genetics analysis of sleep in randomly mutagenized mice (2016)
  • Author(s): Funato H and Yanagisawa M et al.
  • Journal Title: Nature Volume: 539(7629) Issue: 46 Pages: 378-383
  • DOI: 10.1038/nature20142
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Paternal Aging Affects Behavior in Pax6 Mutant Mice: A Gene/Environment Interaction in Understanding Neurodevelopmental Disorders. (2016)
  • Author(s): Yoshizaki K, Furuse, T, Kimura R, Tucci V, Kaneda H, Wakana S and Osumi N
  • Journal Title: PLoS One Volume: 11 Issue: 11 Pages: e0166665-e0166665
  • DOI: 10.1371/journal.pone.0166665
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Oxytocin efficacy is modulated by dosage and oxytocin receptor genotype in young adults with high-functioning autism: a 24-week randomized clinical trial. (2016)
  • Author(s): Kosaka H, Okamoto Y, Munesue T, Yamasue H, Inohara K, Fujioka T, Anme T, Orisaka M, Ishitobi M, Jung M, Fujisawa TX, Tanaka S, Arai S, Asano M, Saito DN, Sadato N, Tomoda A, Omori M, Sato M, Okazawa H, Higashida H, Wada Y.
  • Journal Title: Translational Psychiatry Volume: 6 Issue: 8 Pages: e872-e872
  • DOI: 10.1038/tp.2016.152
  • NAID: 120007129377
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Interaction of Ca2+-dependent activator protein for secretion 1 (CAPS1) with septin family proteins in mouse brain (2016)
  • Author(s): Hosono M, Shinoda Y, Hirano T, Ishizaki Y, Furuichi T and Sadakata T
  • Journal Title: Neurosci. Lett. Volume: 617 Pages: 232-235
  • DOI: 10.1016/j.neulet.2016.02.035
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] CAPS1 stabilizes the state of readily releasable synaptic vesicles to fusion competence at CA3-CA1 synapses in adult hippocampus (2016)
  • Author(s): 6.Shinoda Y, Ishii C, Fukazawa Y, Sadakata T, Ishii Y, Sano Y, Iwasato T, Itohara S, Furuichi T
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 31540-31540
  • DOI: 10.1038/srep31540
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Analysis of gene expression in Ca2+-dependent activator protein for secretion 2 (Cadps2) knockout cerebellum using GeneChip and KEGG pathways (2016)
  • Author(s): Sadakata T, Shinoda Y, Ishizaki Y, Furuichi T.
  • Journal Title: Neuroscience Letters Volume: 639 Pages: 88-93
  • DOI: 10.1016/j.neulet.2016.12.068
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] デメンジョナルな捉え方、RDOCの紹介 (2016)
  • Author(s): 橋本亮太、若菜茂晴
  • Journal Title: 精神科 Volume: 28 Pages: 227-230
• [Journal Article] Promising evidence and remaining issues regarding the clinical application of oxytocin in autism spectrum disorders. (2016)
  • Author(s): Yamasue H.
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 70 Issue: 2 Pages: 89-90
  • DOI: 10.1111/pcn.12364
  • Peer Reviewed
• [Journal Article] Lack of stress responses to long-term effects of corticosterone in Caps2 knockout mice. (2015)
  • Author(s): Yuriko Mishima, Yo Shinoda, Tetsushi Sadakata, Masami Kojima, Shigeharu Wakana, Teiichi Furuichi.
  • Journal Title: Scientific Reports Volume: 5 Issue: 1 Pages: 1-6
  • DOI: 10.1038/srep08932
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] IRBIT is novel determinant of catecholamine homeostasis through the TH phosphorylation by CaMKIIα (2015)
  • Author(s): Katsuhiro Kawaai, Akihiro Mizutani, Hirotaka Shoji, Naoko Ogawa, Etsuko Ebisui, Yukiko Kuroda, Shigeharu Wakana, Tsuyoshi Miyakawa, Chihiro Hisatsune, Katsuhiko Mikoshiba
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 未定 Issue: 17 Pages: 5515-5520
  • DOI: 10.1073/pnas.1503310112
  • Peer Reviewed / Open Access
• [Journal Article] Cognitive Function Related to the Sirh11/Zcchc16 Gene Acquired from an LTR Retrotransposon in Eutherians. (2015)
  • Author(s): Irie M., Yoshikawa M., Ono R., Iwafune H., Furuse T., Yamada I., Wakana S., Yamashita Y., Abe T., *Ishino F., Kaneko-Ishino T.
  • Journal Title: PLoS Genetics Volume: 11 Issue: 9 Pages: 1005521-1005521
  • DOI: 10.1371/journal.pgen.1005521
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Clinical and neural effects of six-week administration of oxytocin on core symptoms of autism. (2015)
  • Author(s): Watanabe T, Kuroda M, Kuwabara H, Aoki Y, Iwashiro N, Natsubori T, Takao H, Nippashi Y, Kawakubo Y, Kunimatsu A, Kasai K, Yamasue H.
  • Journal Title: Brain Volume: 138 Issue: 11 Pages: 3400-3412
  • DOI: 10.1093/brain/awv249
  • Peer Reviewed / Open Access
• [Journal Article] Oxytocin's neurochemical effects in the medial prefrontal cortex underlie recovery of task-specific brain activity in autism: a randomized controlled trial (2015)
  • Author(s): Aoki Y, Watanabe T, Abe O, Kuwabara H, Yahata N, Takano Y, Iwashiro N, Natsubori T, Takao H, Kawakubo Y, Kasai K, Yamasue H
  • Journal Title: Mol Psychiatry Volume: 20 Issue: 4 Pages: 447-53
  • DOI: 10.1038/mp.2014.74
  • Peer Reviewed / Open Access
• [Journal Article] Oxytocin improves behavioural and neural deficits in inferring others’ social emotions in autism (2015)
  • Author(s): Aoki Y, Yamasue H
  • Journal Title: Brain Volume: 137 Issue: 7 Pages: 3073-3086
  • DOI: 10.1093/brain/awv061
  • Peer Reviewed
• [Journal Article] Sirh7/Ldoc1 knockout mice exhibit placental P4 overproduction and delayed parturition. (2014)
  • Author(s): Naruse M, Ono R, Irie M, Nakamura K, Furuse T, Hino T, Oda K, Kashimura M, Yamada I, Wakana S, Yokoyama M, Ishino F, Kaneko-Ishino T.
  • Journal Title: Development Volume: 141 Issue: 24 Pages: 4763-4771
  • DOI: 10.1242/dev.114520
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effects of background mutations and single nucleotide polymorphisms (SNPs) on the Disc1 L100P behavioral phenotype associated with schizophrenia in mice. (2014)
  • Author(s): Arime Y, Fukumura R, Miura I, Mekada K, Yoshiki A, Wakana S, Gondo Y, Akiyama K.
  • Journal Title: Behavioral and Brain Functions Volume: 10 Issue: 1 Pages: 1-13
  • DOI: 10.1186/1744-9081-10-45
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Axonal localization of Ca2+-dependent activator protein for secretion 2 is critical for subcellular locality of brain-derived neurotrophic factor and neurotrophin-3 release affecting proper development of postnatal mouse cerebellum. (2014)
  • Author(s): Sadakata T, Kakegawa W, Shinoda Y, Hosono M, Katoh-Semba R, Sekine Y, Sato Y, Saruta C, Ishizaki Y, Yuzaki M, Kojima M, Furuichi T.
  • Journal Title: PLoS One. Volume: 9(6) Issue: 6 Pages: 1-10
  • DOI: 10.1371/journal.pone.0099524
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Oxytocin improves behavioural and neural deficits in inferring others’ social emotions in autism (2014)
  • Author(s): Aoki Y, Yahata N, Watanabe T, Takano Y, Kawakubo Y, Kuwabara H, Iwashiro N, Natsubori T, Inoue H, Suga M, Takao H, Sasaki H, Gonoi W, Kunimatsu A, Kasai K, Yamasue H
  • Journal Title: Brain Volume: 137 Issue: 11 Pages: 3073-3086
  • DOI: 10.1093/brain/awu231
  • Peer Reviewed / Open Access
• [Presentation] Behavioral-phenotypic characterization of mice that were exposed to abnormal methyl donor metabolism in utero (2017)
  • Author(s): Wakana S, Furuse T.
  • Organizer: RIKEN Epigenetics in Tsukuba
  • Place of Presentation: 理化学研究所（茨城県・つくば市）
  • Year and Date: 2017-02-16
  • Invited
• [Presentation] マルチモダリティMRI指標を活用した自閉スペクトラム症のオキシトシン治療の開発 (2016)
  • Author(s): 山末英典
  • Organizer: 次世代脳プロジェクト 冬のシンポジウ AMED企画シンポジウム「革新的技術開発と治療戦略の最前線」
  • Place of Presentation: 一橋講堂（東京都・千代田区）
  • Year and Date: 2016-12-20
  • Int'l Joint Research
• [Presentation] 対人交渉の困難さの治療薬開発-;アタッチメントホルモン“オキシトシン”の治療応用- (2016)
  • Author(s): 山末英典
  • Organizer: 第26回静岡県こどもの精神保健フォーラム
  • Place of Presentation: 静岡県・沼津市
  • Year and Date: 2016-11-27
  • Int'l Joint Research
• [Presentation] オキシトシンと社会的コミュニケーションの障害 (2016)
  • Author(s): 山末英典
  • Organizer: 第6回社会神経科学研究会
  • Place of Presentation: 生理学研究所（愛知県・岡崎市）
  • Year and Date: 2016-11-24
  • Int'l Joint Research
• [Presentation] オキシトシンと社会行動の障害 (2016)
  • Author(s): 山末英典
  • Organizer: 第50回日本小児内分泌学会イブニングセミナー
  • Place of Presentation: 東京国際フォーラム（東京都・千代田区）
  • Year and Date: 2016-11-16
  • Int'l Joint Research
• [Presentation] Progress of late-onset screen in the IMPC ageing pipeline at Japan Mouse Clinic (2016)
  • Author(s): Wakana S.
  • Organizer: KOMP2 & IMPC Annual Consortium Meeting
  • Place of Presentation: Rockville
  • Year and Date: 2016-10-12
  • Int'l Joint Research
• [Presentation] オキシトシン経鼻剤による社会的コミュニケーションの障害の治療法開発 (2016)
  • Author(s): 山末英典
  • Organizer: 第135回日本薬理学会関東部会シンポジウム2
  • Place of Presentation: アクトシティ浜松 研修交流センター（静岡県・浜松市）
  • Year and Date: 2016-10-08
  • Int'l Joint Research
• [Presentation] An application of neuroimaging to satisfy unmet medical needs associated with autism spectrum disorders (2016)
  • Author(s): Yamasue H.
  • Organizer: JSBN-RIEMS joint Symposium “International educational symposium of prosocial behavior”, 25th JSBN
  • Place of Presentation: ホテル・サンミ倶楽部（静岡県・熱海市）
  • Year and Date: 2016-09-14
  • Int'l Joint Research
• [Presentation] Grin1ミュータントマウスの社会性行動の解析 (2016)
  • Author(s): 京相和貴、宇治田和佳、若菜茂晴、遠藤のぞみ、掛山正心
  • Organizer: 第25回日本行動神経内分泌研究会
  • Place of Presentation: ホテル・サンミ倶楽部（静岡県・熱海市）
  • Year and Date: 2016-09-13
• [Presentation] Principles of mouse phenotyping (2016)
  • Author(s): Wakana S.
  • Organizer: 2016 KALAS International Symposium
  • Place of Presentation: Gyeongju
  • Year and Date: 2016-08-24
  • Int'l Joint Research / Invited
• [Presentation] メチオニン関連遺伝子欠損マウスを母体とした仔の行動表現型解解析 (2016)
  • Author(s): 古瀬民生、幸田尚、三宅邦夫、三浦郁生、串田知子、山田郁子、柏村実生、金田秀貴、小林喜美男、石野史敏、若菜茂晴
  • Organizer: 第5回日本DOHaD研究会学術集会
  • Place of Presentation: 国立成育医療研究センター
  • Year and Date: 2016-07-23
• [Presentation] Phenotypic analysis of wild-type progeny which recipient mother carries mutation in one-carbon-metabolism related gene (2016)
  • Author(s): Furuse T, Kohda T, Miyake K, Kushida T, Yamada I, Kashimura M, Miura I, Kaneda H, Kobayashi K, Ishino F, Wakana S.
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2016-07-20
• [Presentation] Early weaning induces high-dominance social behavior of mice under group-housed conditions (2016)
  • Author(s): Ujita W, Endo N, Ichikawa D,Saito T, Oyama H, Kakeyama M.
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2016-07-20
• [Presentation] 遺伝子情報による自閉スペクトラム症に対するオキシトシン投与効果の予測 (2016)
  • Author(s): 山末英典
  • Organizer: 第46回日本神経精神薬理学会年会
  • Place of Presentation: Seoul
  • Year and Date: 2016-07-02
  • Int'l Joint Research
• [Presentation] ヒト精神疾患モデルマウス行動表現型のRDoC (Research Domain of Criteria）マトリックスへの試み (2016)
  • Author(s): 若菜茂晴、古瀬民生、山田郁子、串田知子、柏村実生
  • Organizer: 第63回日本実験動物学会総会
  • Place of Presentation: ミューザ川崎（神奈川県・川崎市）
  • Year and Date: 2016-05-18
• [Presentation] IMPC行動表現型解析におけるコントロールデータの解析 (2016)
  • Author(s): 山田郁子、串田知子、柏村実生、鈴木智広、金田秀貴、小林喜美男、三浦郁生、古瀬民生、若菜茂晴
  • Organizer: 第63回日本実験動物学会総会
  • Place of Presentation: ミューザ川崎（神奈川県・川崎市）
  • Year and Date: 2016-05-18
• [Presentation] Predictability Of Oxytocin’s Efficacy With Genotype Information In Autism Spectrum Disorders (2016)
  • Author(s): Yamasue H.
  • Organizer: SOBP's 71st Annual Meeting
  • Place of Presentation: Atlanta
  • Year and Date: 2016-05-12
  • Int'l Joint Research
• [Presentation] 高次脳機能の健康を阻害する幼少期の環境要因と遺伝要因 (2016)
  • Author(s): 掛山正心
  • Organizer: 第86回日本衛生学会学術総会シンポジウム
  • Place of Presentation: 旭川市民文化会館（北海道・旭川市）
  • Year and Date: 2016-05-11
  • Invited
• [Presentation] Challenging to the Autophagy related screen in the aging pipeline (2016)
  • Author(s): Wakana S.
  • Organizer: IMPC-INFRAFRONTIER Strasburg meeting
  • Place of Presentation: Strasburg
  • Year and Date: 2016-04-20
  • Int'l Joint Research
• [Presentation] Can Neuroimaging Contribute to Satisfying Unmet Medical Needs Associated with Autism Spectrum Disorders? (2016)
  • Author(s): Yamasue H
  • Organizer: The Sixteenth Conference of Peace through Mind/Brain Science
  • Place of Presentation: Hamamatsu, Japan
  • Year and Date: 2016-02-23
  • Int'l Joint Research / Invited
• [Presentation] マウス表現型解析の標準化と疾患モデルマウス開発への新たな展開 (2016)
  • Author(s): 若菜茂晴
  • Organizer: 慶應義塾大学医学部 坂口記念システム医学講座セミナー
  • Place of Presentation: 慶應義塾大学信濃町キャンパス（東京都・新宿区信濃町）
  • Invited
• [Presentation] Dissemination of the standardized phenotyping, resources and data in mice from RIKEN BRC for the advancement of biomedical research (2015)
  • Author(s): Wakana S
  • Organizer: IMPC International Symposium in Yokohama
  • Place of Presentation: Yokohama Port Opening Memorial Hall, Yokohama, Japan
  • Year and Date: 2015-11-12
  • Int'l Joint Research
• [Presentation] Challenging to RDoC matrix in behavior phenotype of mouse models for human psychiatric disorders (2015)
  • Author(s): Wakana S, Yamada I, Kashimura M, Kushida T, Furuse T
  • Organizer: 29th International Mammalian Genome Conference
  • Place of Presentation: Yokohama Port Opening Memorial Hall, Yokohama, Japan
  • Year and Date: 2015-11-08
  • Int'l Joint Research
• [Presentation] マウスを用いた前頭野依存性行動モデル：高次学習から実行機能へ (2015)
  • Author(s): 掛山正心
  • Organizer: 第45回日本神経精神薬理学会・第37回日本生物学的精神医学会シンポジウム
  • Place of Presentation: タワーホール船堀, 東京
  • Year and Date: 2015-09-26
  • Int'l Joint Research / Invited
• [Presentation] Social Interaction for Standardized Behavioral Phenotyping (2015)
  • Author(s): Wakana S
  • Organizer: IMPC-INFRAFRONTIER Seoul Meeting
  • Place of Presentation: PLAZA Hotel, Seoul, Korea
  • Year and Date: 2015-09-14
  • Int'l Joint Research / Invited
• [Presentation] Brain development transcriptome database and developmental disorder. (2015)
  • Author(s): Furuichi T
  • Organizer: Neuroinformatics 2015
  • Place of Presentation: Cairns, Australia
  • Year and Date: 2015-08-20
  • Int'l Joint Research / Invited
• [Presentation] A comprehensive mouse phenotyping platform in the Japan Mouse Clinic (2015)
  • Author(s): Wakana S
  • Organizer: 2015 30th anniversary KALAS Internaional Symposium
  • Place of Presentation: Songdo Convensia, Incheon, Korea
  • Year and Date: 2015-08-12
  • Int'l Joint Research / Invited
• [Presentation] Animal models of autism spectrum disorders: CAPS2 is critical for proper brain development and social behavior. (2015)
  • Author(s): Furuichi T
  • Organizer: International Symposium of the Center for Animal Disease Model
  • Place of Presentation: Gakushikaikan, Tokyo
  • Year and Date: 2015-07-21
  • Int'l Joint Research / Invited
• [Presentation] 自閉症スペクトラム症者への経鼻的オキシトシン継続投与の臨床試験報告と今後の展開 (2015)
  • Author(s): 山末英典
  • Organizer: 第111回日本精神神経学会学術総会ワークショップ
  • Place of Presentation: リーガロイヤルホテル, 大阪
  • Year and Date: 2015-06-04
  • Invited
• [Presentation] 自閉症スペクトラム症におけるオキシトシン薬効発現の脳内メカニズムの探索 (2015)
  • Author(s): 山末英典
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 兵庫県神戸市、神戸学院大学
  • Year and Date: 2015-03-27
• [Presentation] 自閉症スペクトラム症の中核症状治療薬開発のためのオキシトシン臨床研究 (2015)
  • Author(s): 山末英典
  • Organizer: 第120回日本解剖学会総会・全国学術集会、第92回日本生理学会大会
  • Place of Presentation: 兵庫県神戸市、神戸国際会議場
  • Year and Date: 2015-03-23
• [Presentation] Oxytocin-function on brain and its future possibilities for treatment of ASD (2015)
  • Author(s): 山末英典
  • Organizer: The 1st Biannual International Seminar of Translational Research Center fot Autism
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2015-01-23
  • Invited
• [Presentation] マウス小脳をモデルとした生後期の脳発達と遺伝子発現 (2014)
  • Author(s): 古市貞一
  • Organizer: 第51回 群馬大学脳神経発達統御学セミナー、第9回 ASRLDユニット研究セミナー
  • Place of Presentation: 群馬県前橋市、群馬大学医学部
  • Year and Date: 2014-12-05
• [Presentation] 中枢神経系疾患におけるunmet medical needs－自閉症の治療薬開発－ (2014)
  • Author(s): 山末英典
  • Organizer: 第35回日本臨床薬理学会学術総会
  • Place of Presentation: 愛媛県松山市、ひめぎんホール
  • Year and Date: 2014-12-05
• [Presentation] Neural and behavioral effects of oxytocin on autistic difficulty in social communication (2014)
  • Author(s): 山末英典
  • Organizer: Oxytocin - Mechanistic Insights and Therapeutic Perspectives
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2014-11-27
• [Presentation] 対人コミュニケーションの障害の治療薬開発への脳画像解析の応用 (2014)
  • Author(s): 山末英典
  • Organizer: 第20回東京臨床脳画像解析研究会
  • Place of Presentation: 東京都港区、東京コンファレンスセンター・品川
  • Year and Date: 2014-11-22
• [Presentation] Characterizing behavioral flexibility impairment in mouse models of cognitive deficits induced by N-ethyl-N-nitrosourea mutagenesis and p-chlorophenylalanine (2014)
  • Author(s): Endo T, Benner S, Ling W, Endo N, Kimura E, Furuse T, Wakana S, Bito H, Tohyama C, Kakeyama M
  • Organizer: Neuroscience 2014
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2014-11-19
• [Presentation] Brain-specific expression of lysosomal-associated membrane protein 5 (LAMP5) gene (2014)
  • Author(s): Koebis M, Saito Y, Sshinoda Y, Furuichi T
  • Organizer: Neuroscience 2014
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2014-11-17
• [Presentation] Age-dependent redistribution and hypersialylation of the central myelin loop membrane protein Opalin in the mouse brain (2014)
  • Author(s): Furuichi T, Sato Y, Yoshikawa F, Sadakata T, Sshinoda Y, Koebis M
  • Organizer: Neuroscience 2014
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2014-11-16
• [Presentation] Introduction to the Japan Mouse Clinic and challenging for RDoC matrix based mouse behavior phenotype (2014)
  • Author(s): Wakana S
  • Organizer: ICS Seminar
  • Place of Presentation: Illkirch, France
  • Year and Date: 2014-11-14
  • Invited
• [Presentation] Trends in standardization of mouse phenotyping and introduction of the Japan Mouse Clinic (2014)
  • Author(s): Wakana S
  • Organizer: AFLAS Congress 2014
  • Place of Presentation: Kuala Lumpur, Malaysia
  • Year and Date: 2014-11-11
  • Invited
• [Presentation] Trends in standardization of mouse phenotyping and the Japan Mouse Clinic (2014)
  • Author(s): Wakana S
  • Organizer: AMMRA-AMPC Student Workshop
  • Place of Presentation: Canberra, Australia
  • Year and Date: 2014-10-22
  • Invited
• [Presentation] BDNFの分泌と自閉症 (2014)
  • Author(s): 定方哲史、篠田陽、古市貞一
  • Organizer: 第36回日本生物学的精神医学会・第57回日本神経化学会大会
  • Place of Presentation: 奈良県奈良市、奈良文化会館
  • Year and Date: 2014-10-01
• [Presentation] 自閉症スペクトラム障害関連の遺伝的な変異や多様性をもった動物モデル (2014)
  • Author(s): 古市貞一
  • Organizer: 第36回日本生物学的精神医学会・第57回日本神経化学会大会
  • Place of Presentation: 奈良県奈良市、奈良文化会館
  • Year and Date: 2014-09-30
• [Presentation] Trends in standardization of mouse phenotyping and introduction of the Japan Mouse Clinic (2014)
  • Author(s): Wakana S
  • Organizer: Korea Institute of Toxicology Seminar
  • Place of Presentation: Daejeon, Korea
  • Year and Date: 2014-09-25
  • Invited
• [Presentation] Introduction of the Japan Mouse Clinic and challenging of mouse behavior phenotyping (2014)
  • Author(s): Wakana S
  • Organizer: KRIBB Seminar
  • Place of Presentation: Daejeon, Korea
  • Year and Date: 2014-09-24
  • Invited
• [Presentation] Trends in standardization of mouse phenotyping and introduction of the Japan Mouse Clinic (2014)
  • Author(s): Wakana S
  • Organizer: Seoul National University Seminar
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2014-09-23
  • Invited
• [Presentation] Trends in standardization of mouse phenotyping and introduction of the Japan Mouse Clinic (2014)
  • Author(s): Wakana S
  • Organizer: Samsung Seminar
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2014-09-22
  • Invited
• [Presentation] 成体ニューロン新生におけるCAPS2の役割 (2014)
  • Author(s): 柳下香織、篠田陽、古市貞一
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: 神奈川県横浜市、パシフィコ横浜
  • Year and Date: 2014-09-13
• [Presentation] Development of Touchscreen-Based Tests for Measuring Behavioral Inhibition in Mice (2014)
  • Author(s): Okada A, Endo T, Tohayama C, Kakeyama M
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: 神奈川県横浜市、パシフィコ横浜
  • Year and Date: 2014-09-12
• [Presentation] 長期増強のシナプス特異性に寄与するプレシナプスタグの探求 (2014)
  • Author(s): 齊藤新平、篠田陽、定方哲史、西岡朋生、貝淵弘三、古市貞一
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: 神奈川県横浜市、パシフィコ横浜
  • Year and Date: 2014-09-12
• [Presentation] シナプス小胞と有芯小胞における同時イメージング解析 (2014)
  • Author(s): 中島柚依、篠田陽、古市貞一
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: 神奈川県横浜市、パシフィコ横浜
  • Year and Date: 2014-09-12
• [Presentation] Challenging to RDoC matrix chart in the phenotypes of Grin1Rgsc174 mouse (2014)
  • Author(s): Wakana S
  • Organizer: KOMP2/IMPC Annual Consortium Meeting
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2014-07-01
• [Book] 実験医学別冊 マウス表現型解析スタンダード (2016)
  • Author(s): 伊川正人、高橋智、若菜茂晴 編集
  • Total Pages: 347
  • Publisher: 羊土社
• [Book] 「自閉症スペクトラム症とオキシトシン」Annual Review糖尿病・代謝・内分泌2016 (2016)
  • Author(s): 山末英典
  • Publisher: 中外医学社
• [Book] 「自閉スペクトラム症の脳画像研究」Clinical Neuroscience (2015)
  • Author(s): 山末英典
  • Publisher: 中外医学社
• [Book] 「自閉症スペクトラム障害の脳画像研究」臨床心理学 (2014)
  • Author(s): 山末英典
  • Publisher: 金剛出版
• [Book] 「精神医学領域における扁桃体の脳画像研究」Clinical Neuroscience (2014)
  • Author(s): 山末英典
  • Publisher: 中外医学社