|Budget Amount *help
¥40,430,000 (Direct Cost: ¥31,100,000、Indirect Cost: ¥9,330,000)
Fiscal Year 2017: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2016: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2015: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2014: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
|Outline of Final Research Achievements
In this study, we have identified molecules that are involved in EDAC (epithelial defense against cancer) whereby transformed cells are eliminated from epithelia via cell competition with the surrounding normal epithelial cells. First, we have found that expression of a soluble factor ADAMDEC1 is non-cell-autonomously upregulated in normal cells neighboring transformed cells, which positively regulate apical extrusion of transformed cells. In addition, we also demonstrate that expression of COX-2 is increased in normal cells surrounding transformed cells, which induces inflammatory responses thereby negatively regulating cell competition. Collectively, these results indicate the presence of both negative and positive regulators of cell competition.