| Budget Amount *help |
¥30,160,000 (Direct Cost: ¥23,200,000、Indirect Cost: ¥6,960,000)
Fiscal Year 2016: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2015: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2014: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
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| Outline of Final Research Achievements |
The cell responds to environmental changes by altering its genome expression pattern, but not the genome sequences per se, and inherits the pattern even after cell division. This mechanism is called epigenetics, which is based on various chemical modifications of DNA and proteins comprising the chromosomes, and the term epigenome indicates the genome-wide pattern of these epigenetic modifications. It becomes increasingly possible to read, write, and visualize the epigenetics of targeted genomic regions by combining the technologies of CRISPR/Cas9-based genome editing and the next-generation DNA sequencing. In this study, we have developed basic methods for these novel approaches in epigenomics.
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