| Budget Amount *help |
¥40,560,000 (Direct Cost: ¥31,200,000、Indirect Cost: ¥9,360,000)
Fiscal Year 2016: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2015: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2014: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
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| Outline of Final Research Achievements |
In this project, we focus on the molecular mechanism of RNA polymerizations by CC-, A- CCA-adding enzymes and by RNA polymerase complexed with S1 protein. We clarified the mechanisms of CC-addition and A-addition by CC-adding and A-adding enzymes, respectively. We also clarify the mechanism by which CCA-adding enzyme discriminates mature tRNA from immature tRNA. We also clarified the molecular basis of replication initiation by using S1 protein in RNA polymerase complex.
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