Research Project
Grant-in-Aid for Scientific Research (A)
The roles and modes of action of nectins in heterotypic cell-cell adhesions were investigated. We identified a novel cell adhesion apparatus formed by the heterophilic trans-interaction between nectin-4 and nectin-1, which were expressed in the luminal and basal cells in the mammary gland, respectively. Nectin-4 in this apparatus enhanced the prolactin receptor signaling. Moreover, we showed that nectin-2 and nectin-3 expressed in olfactory and supporting cells, respectively, interacted in trans and recruited cadherin to the heterotypic cell junctions, resulting in the formation of the mosaic pattern in the olfactory epithelium. Further, we showed that nectin-2δ was localized on the plasma membranes of astrocytic perivascular endfoot processes facing the basement membrane of blood vessels in the brain. Genetic ablation of nectin-2 caused degeneration of the astrocytic perivascular endfoot processes and neurons, indicating that nectin- 2 is required to maintain the brain structures.
All 2017 2016 2015 2014
All Journal Article (27 results) (of which Int'l Joint Research: 1 results, Peer Reviewed: 27 results, Open Access: 15 results, Acknowledgement Compliant: 10 results) Presentation (12 results) (of which Invited: 2 results) Patent(Industrial Property Rights) (1 results)
Journal of Biological Chemistry
Volume: 292 Issue: 17 Pages: 6895-6909
10.1074/jbc.m116.769091
Mol Cell Neurosci
Volume: 79 Pages: 34-44
10.1016/j.mcn.2016.12.007
Genes to Cells
Volume: 印刷中 Issue: 5 Pages: 472-484
10.1111/gtc.12489
J Comp Neurol
Volume: 印刷中
Eur J Neurosci.
Volume: 44 Issue: 5 Pages: 2272-2284
10.1111/ejn.13331
Brain Res
Volume: 1649 Pages: 90-101
10.1016/j.brainres.2016.08.023
Biochemical Journal
Volume: 473 Issue: 18 Pages: 2691-2715
10.1042/bcj20160235
Genes Cells
Volume: 21 Issue: 1 Pages: 88-98
10.1111/gtc.12322
The Journal of Cell Biology
Volume: 212 Issue: 5 Pages: 561-75
10.1083/jcb.201509020
120005766825
Volume: 291 Issue: 11 Pages: 5817-5831
10.1074/jbc.m115.685917
Volume: 71 Pages: 25-33
10.1016/j.mcn.2015.12.005
Volume: 68 Pages: 143-150
10.1016/j.mcn.2015.07.003
Volume: 523 Issue: 12 Pages: 1824-1839
10.1002/cne.23762
Volume: 43 Pages: 775-86
10.1016/j.brainres.2015.05.012
PLoS One
Volume: 10 Issue: 6 Pages: e0130032-e0130032
10.1371/journal.pone.0130032
PloS One.
Volume: 10 Issue: 4 Pages: e0124259-e0124259
10.1371/journal.pone.0124259
J Comp Neurol.
PLoS Pathog.
Volume: 16 Issue: 3 Pages: e1004721-e1004721
10.1371/journal.ppat.1004721
Curr Top Dev Biol.
Volume: 112 Pages: 197-231
10.1016/bs.ctdb.2014.11.019
Protein Sci.
Volume: 24 Issue: 3 Pages: 376-385
10.1002/pro.2628
J Histochem Cytochem.
Volume: 63 Issue: 2 Pages: 99-113
10.1369/0022155414562045
120005593935
PLoS One.
Volume: 9 Issue: 10 Pages: e110549-e110549
10.1371/journal.pone.0110549
Genes Cells.
Volume: 19 Issue: 11 Pages: 842-852
10.1111/gtc.12184
Volume: 19 Issue: 12 Pages: 853-863
10.1111/gtc.12185
J Clin Invest.
Volume: 124 Issue: 10 Pages: 4503-4516
10.1172/jci71245
Volume: 124 Issue: 10 Pages: 4517-4528
10.1172/jci75572
Volume: 19 Issue: 9 Pages: 667-675
10.1111/gtc.12166