Study on molecular machinery of suppression of neurodegeneration by autophagy and drug discovery research

• Project/Area Number: 26251020
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cell biology
• Research Institution: Osaka University
• Principal Investigator: Yoshimori Tamotsu 大阪大学, 生命機能研究科, 教授 (60191649)
• Project Period (FY): 2014-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥39,520,000 (Direct Cost: ¥30,400,000、Indirect Cost: ¥9,120,000); Fiscal Year 2018: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000); Fiscal Year 2017: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000); Fiscal Year 2016: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000); Fiscal Year 2015: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000); Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
• Keywords: オートファジー / 神経変性疾患 / Rubicon / パーキンソン病 / 低分子化合物 / 脳神経疾患 / たんぱく質分解 / ＫＯマウス

Outline of Final Research Achievements

The intracellular degradation system, autophagy is known to degrade aggregate-prone proteins causing neurodegeneration including Parkinson disease. We found that suppression of Rubicon, a negative regulator of autophagy enhances these proteins. In addition, we identified several Low molecular weight compounds, which are candidates for activating autophagy thereby promote degradation of the proteins.

Academic Significance and Societal Importance of the Research Achievements

アルツハイマー病やパーキンソン病等の神経変性疾患は、超高齢社会を迎える我が国の重要課題です。それを抑える細胞の仕組みの一端を明らかにできたことと、そしてその結果治療の標的となりうるタンパク質が判ったことは学術的にも社会的にも大きな意義があります。さらにこの研究で発見したオートファジーを促進する化合物は、将来これらの病気の治療薬の開発に結びつくことが期待されます。

Research Products

• [Journal Article] Suppression of autophagic activity by Rubicon is a signature of aging. (2019)
  • Author(s): Nakamura S, Oba M, Suzuki M, Takahashi A, Yamamuro T, Fujiwara M, Ikenaka K, Minami S, Tabata N, Yamamoto K, Kubo S, Tokumura A, Akamatsu K, Miyazaki Y, Kawabata T, Hamasaki M, Fukui K, Sango K, Watanabe Y, Takabatake Y, Kitajima T, Okada Y, Mochizuki H, Isaka Y, Antebi A, Yoshimori T.
  • Journal Title: Nat Commun Volume: 10 Issue: 1 Pages: 847-847
  • DOI: 10.1038/s41467-019-08729-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Distinct functions of ATG16L1 isoforms in membrane binding and LC3B lipidation in autophagy-related processes (2019)
  • Author(s): Lystad AH*, Carlsson SR*, de la Ballina LR, Kauffman KJ, Nag S, Yoshimori T, Melia TJ, Simonsen A
  • Journal Title: Nat. Cell. Biol. Volume: 21 Issue: 3 Pages: 372-383
  • DOI: 10.1038/s41556-019-0274-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A brain-enriched Drp1 isoform associates with lysosomes, late endosomes and the plasma membrane (2018)
  • Author(s): Itoh K, Adachi Y, Yamada T, Suzuki TL, Otomo T, McBride HM, Yoshimori T, Iijima M, Sesaki H
  • Journal Title: J. Biol. Chem. Volume: 293 Issue: 30 Pages: 11809-11822
  • DOI: 10.1074/jbc.ra117.001253
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Trophoblast-Specific Conditional Atg7 Knockout Mice Develop Gestational Hypertension (2018)
  • Author(s): Aoki A, Nakashima A, Kusabiraki T, Ono Y, Yoshino O, Muto M, Kumasawa K, Yoshimori T, Ikawa M, Saito S
  • Journal Title: Am. J. Pathol. Volume: 188 Issue: 11 Pages: 2474-2486
  • DOI: 10.1016/j.ajpath.2018.07.021
  • Peer Reviewed
• [Journal Article] Transgenic expression of a ratiometric autophagy probe specifically in neurons enables the interrogation of brain autophagy in vivo (2018)
  • Author(s): Lee JH, Rao MV, Yang DS, Stavrides P, Im E, Pensalfini A, Huo C, Sarkar P, Yoshimori T, Nixon RA
  • Journal Title: Autophagy Volume: 15 Issue: 3 Pages: 543-557
  • DOI: 10.1080/15548627.2018.1528812
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Induction of selective autophagy in cells replicating hepatitis C virus genome (2018)
  • Author(s): Mori Hiroyuki、Fukuhara Takasuke、Ono Chikako、Tamura Tomokazu、Sato Asuka、Fauzyah Yuzy、Wada Masami、Okamoto Toru、Noda Takeshi、Yoshimori Tamotsu、Matsuura Yoshiharu
  • Journal Title: Journal of General Virology Volume: 99 Issue: 12 Pages: 1643-1657
  • DOI: 10.1099/jgv.0.001161
  • Peer Reviewed / Open Access
• [Journal Article] An ATG16L1-dependent pathway promotes plasma membrane repair and limits Listeria monocytogenes cell-to-cell spread (2018)
  • Author(s): Tan JM, Mellouk N, Osborne SE, Ammendolia DA, Dyer DN, Li R, Brunen D, van Rijn JM, Huang J, Czuczman MA, Cemma MA, Won AM, Yip CM, Xavier RJ, MacDuff DA, Reggiori F, Debnath J, Yoshimori T, Kim PK, Fairn GD, Coyaud E, Raught B, Muise AM, Higgins DE, Brumell JH
  • Journal Title: Nat. Microbiol. Volume: 3 Issue: 12 Pages: 1472-1485
  • DOI: 10.1038/s41564-018-0293-5
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Bidirectional Control of Autophagy by BECN1 BARA Domain Dynamics (2018)
  • Author(s): Chang C, Young LN, Morris KL, von Buelow S, Schoeneberg J, Yamamoto-Imoto H, Oe Y, Yamamoto K, Nakamura S, Stjepanovic G, Hummer G, Yoshimori T, Hurley JH
  • Journal Title: Mol. Cell. Volume: 73 Issue: 2 Pages: 339-353
  • DOI: 10.1016/j.molcel.2018.10.035
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The PtdIns3-phosphatase MTMR3 interacts with mTORC1 and suppresses its activity. (2016)
  • Author(s): Hao F, Itoh T, Morita E, Shirahama-Noda K, Yoshimori T, Noda T.
  • Journal Title: FEBS Lett. Volume: 509 Issue: 1 Pages: 161-173
  • DOI: 10.1002/1873-3468.12048
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Human IAPP-induced pancreatic β cell toxicity and its regulation by autophagy. (2014)
  • Author(s): Shigihara N, Fukunaka A, Hara A, Komiya K, Honda A, Uchida T, Abe H, Toyofuku Y, Tamaki M, Ogihara T, Miyatsuka T, Hiddinga HJ, Sakagashira S, Koike M, Uchiyama Y, Yoshimori T, Eberhardt NL, Fujitani Y, Watada H.
  • Journal Title: J Clin Invest. Volume: 124 Issue: 8 Pages: 3634-44
  • DOI: 10.1172/jci69866
  • Peer Reviewed / Open Access
• [Journal Article] Reciprocal conversion of Gtr1 and Gtr2 nucleotide- binding states by Npr2-Npr3 inactivates TORC1 and induces autophagy. (2014)
  • Author(s): Kira S, Tabata K, Shirahama-Noda K, Nozoe A, Yoshimori T, Noda T.
  • Journal Title: Autophagy. Volume: 10 Issue: 9 Pages: 1565-78
  • DOI: 10.4161/auto.29397
  • Peer Reviewed / Open Access
• [Journal Article] The parasitophorous vacuole membrane of Toxoplasma gondii is targeted for disruption by ubiquitin-like conjugation systems of autophagy. (2014)
  • Author(s): Choi J, Park S, Biering SB, Selleck E, Liu CY, Zhang X, Fujita N, Saitoh T, Akira S, Yoshimori T, Sibley LD, Hwang S, Virgin HW.
  • Journal Title: Immunity. Volume: 40 Issue: 6 Pages: 924-35
  • DOI: 10.1016/j.immuni.2014.05.006
  • Peer Reviewed
• [Journal Article] Autophagy induced by calcium phosphate precipitates targets damaged endosomes. (2014)
  • Author(s): Chen X, Khambu B, Zhang H, Gao W, Li M, Chen X, Yoshimori T, Yin XM.
  • Journal Title: J Biol Chem. Volume: 289 Issue: 16 Pages: 11162-74
  • DOI: 10.1074/jbc.m113.531855
  • Peer Reviewed / Open Access
• [Presentation] オートファジー：疾患に対抗し寿命を延ばす細胞の守護者 (2019)
  • Author(s): 吉森保
  • Organizer: 第１回 医学系研究科-産業科学研究所懇話会
  • Invited
• [Presentation] Autophagy: Its molecular machinery and implications in diseases (2019)
  • Author(s): 吉森保
  • Organizer: The 1st OIST-OU Joint Symposium “Cell Biology and Immunology”,
  • Int'l Joint Research / Invited
• [Presentation] Suppression of Autophagy by Rubicon Is Signature of Aging. (2019)
  • Author(s): 吉森保
  • Organizer: Keystone Symposia on Molecular and Cellular Biology "Autophagy: From Model Systems to Therapeutic Opportunities"
  • Int'l Joint Research / Invited
• [Presentation] Dissection of Molecular Mechanisms in Lysophagy (2018)
  • Author(s): 吉森保
  • Organizer: Keystone Symposia on Molecular and Cellular Biology "Selective Autophagy"
  • Int'l Joint Research / Invited
• [Presentation] オートファジー：感染症などの疾患に対抗する細胞の守護者 (2018)
  • Author(s): 吉森保
  • Organizer: 第92回日本感染症学会学術講演会・第66回日本化学療法学会総会
  • Invited
• [Presentation] オートファジーによる疾患抑制の分子機構 (2018)
  • Author(s): 吉森保
  • Organizer: 千里ライフサイエンスセミナーM２:オートファジーと疾患
  • Invited
• [Presentation] 疾患と老化に対抗するオートファジー (2018)
  • Author(s): 吉森保
  • Organizer: 新潟大学教育研究特別シンポジウム
  • Invited
• [Presentation] オートファジー：疾患に対抗し寿命を延長する細胞内分解システム (2018)
  • Author(s): 吉森保
  • Organizer: 第34回創薬セミナー
  • Invited
• [Presentation] オートファジー：疾患と老化に対抗する細胞の恒常性維持機構 (2018)
  • Author(s): 吉森保
  • Organizer: 第2回Aging Forum
  • Invited
• [Presentation] Autophagy and its Relevance to Movement Disorders (2018)
  • Author(s): 吉森保
  • Organizer: MDS Basic Science Summer School
  • Int'l Joint Research / Invited
• [Presentation] 22 Years of Autophagy: towards Understanding the Cellular Self-Degradation System Fighting against Diseases and Aging (2018)
  • Author(s): 吉森保
  • Organizer: Keynote lecture in 2nd Nordic Autophagy Society Conference
  • Int'l Joint Research / Invited
• [Presentation] 細胞の守護者オートファジー：疾患と老化に対抗する細胞恒常性維持機構 (2018)
  • Author(s): 吉森保
  • Organizer: 第16回高付加価値食品開発のためのフォーラム（シーズとニーズの新たな出会い）
  • Invited
• [Presentation] 21 Years of Autophagy: towards Understanding the Intracellular Degradation System Fighting against Diseases and Aging (2018)
  • Author(s): 吉森保
  • Organizer: 26th Conference of the European Cell Death Organization “Cell death in disease: from small molecules to translational medicine”
  • Int'l Joint Research / Invited
• [Presentation] A E3 Ligase in Lysophagy and Xenophagy in Endothelial Cells (2018)
  • Author(s): 吉森保
  • Organizer: HFSP meeting 2018 in Osaka~The physical basis of autophagosome biogenesis~
  • Int'l Joint Research / Invited
• [Presentation] オートファジーによる疾患制御の分子機構 (2018)
  • Author(s): 吉森保
  • Organizer: 第40回北海等大学獣医学学術交流基金群講演会
  • Invited
• [Presentation] 組織によってオートファジーの能力や役割は異なる (2018)
  • Author(s): 吉森保
  • Organizer: 第11回オートファジー研究会
  • Invited
• [Presentation] オートファジーとは何か：ノーベル賞の大隅先生と挑んだ21年 (2018)
  • Author(s): 吉森保
  • Organizer: 安田記念医学財団創立30周年記念講演会
  • Invited
• [Presentation] Selective Autophagy and Diseases (2016)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Keynote Session in The Gordon Research Conference on Autophagy in Stress, Development & Disease
  • Place of Presentation: Ventura Beach Marriott, Ventura, USA
  • Year and Date: 2016-03-21
  • Int'l Joint Research / Invited
• [Presentation] 20 years of Autophagy: towards Understanding the Intracellular Self-Degradation System Fighting against Diseases (2016)
  • Author(s): Tamotsu Yoshimori
  • Organizer: 2016 International A3 Foresight Symposium on Autophagy
  • Place of Presentation: Chungnam National University, Daejeon, Korea
  • Year and Date: 2016-02-26
  • Int'l Joint Research / Invited
• [Presentation] Mechanistic Insights into Membrane Dynamics in Autophagy (2016)
  • Author(s): Tamotsu Yoshimori
  • Organizer: FRIAS Black Forrest Winter Conference on Autophagic Membrane Trafficking and Dynamics in Ageing and Disease
  • Place of Presentation: Hotel Saigerhoeh, Freiburg, Germany
  • Year and Date: 2016-01-31
  • Int'l Joint Research / Invited
• [Presentation] Autophagy: The Intracellular Self-Degradation System Fighting against Disease. (2016)
  • Author(s): Tamotsu Yoshimori
  • Organizer: The5th NIF Winter School on Advanced Immunology
  • Place of Presentation: Awaji Yumebutai International Conference Center, Awaji Island, Japan
  • Year and Date: 2016-01-20
  • Int'l Joint Research / Invited
• [Presentation] 細胞の守護者オートファジー：疾患に対抗する細胞内自己分解システム (2015)
  • Author(s): 吉森 保
  • Organizer: 第5回 MD研究者養成コース四大学コンソーシアムリトリート
  • Place of Presentation: ザ・パレスサイドホテル, 京都
  • Year and Date: 2015-12-05
  • Invited
• [Presentation] オートファジー：疾患に対抗する細胞内大規模分解系 (2015)
  • Author(s): 吉森 保
  • Organizer: 第452回日本皮膚科学会大阪地方会・第22回小林浩記念講演
  • Place of Presentation: 大阪科学技術センター, 大阪
  • Year and Date: 2015-12-05
  • Invited
• [Presentation] オートファジーによる病態抑制のメカニズム (2015)
  • Author(s): 吉森 保
  • Organizer: 第38回日本分子生物学会年会・第88回日本生化学会大会合同大会 (BMB2015) オリンパス(株)ランチョンセミナー
  • Place of Presentation: 神戸国際会議場, 神戸
  • Year and Date: 2015-12-03
  • Invited
• [Presentation] New Insights into Autophagy in Disease (2015)
  • Author(s): Tamotsu Yoshimori
  • Organizer: 第38回日本分子生物学会年会・第88回日本生化学会大会合同大会 (BMB2015) 1S14:科学研究費補助金 新学術領域研究「オートファジーの集学的研究：分子基盤から疾患まで」共催シンポジウム Autophagy
  • Place of Presentation: 神戸国際会議場, 神戸
  • Year and Date: 2015-12-01
  • Int'l Joint Research / Invited
• [Presentation] オートファジーの膜動態：分子機構と疾患との関わり (2015)
  • Author(s): 吉森 保
  • Organizer: 第９回オートファジー研究会・新学術領域研究「オートファジーの集学的研究：分子基盤から疾患まで」第３回班会議, セッション6 (分子機構・膜動態)
  • Place of Presentation: 淡路夢舞台国際会議場, 淡路
  • Year and Date: 2015-11-17
  • Invited
• [Presentation] Autophagy: Molecular Machinery and Role in Suppression of Diseases (2015)
  • Author(s): Tamotsu Yoshimori
  • Organizer: The 14th CRG symposium: Cellular Machineries
  • Place of Presentation: PRBB auditorium CRG, Bercelona, Spain
  • Year and Date: 2015-10-23
  • Int'l Joint Research / Invited
• [Presentation] New Insights into Membrane Biogenesis and Targeting in Autophagy (2015)
  • Author(s): Tamotsu Yoshimori
  • Organizer: EMBO Conference on Autophagy: Autophagy signaling and progression in health and disease
  • Place of Presentation: Chia Laguna Resort, Chia, Italy
  • Year and Date: 2015-09-10
  • Int'l Joint Research / Invited
• [Presentation] 疾患に対抗する細胞内大規模分解システム・オートファジー (2015)
  • Author(s): 吉森 保
  • Organizer: 第2回GSK皮膚免疫カンファレンス
  • Place of Presentation: 大津プリンスホテル, 滋賀
  • Year and Date: 2015-07-25
  • Int'l Joint Research / Invited
• [Presentation] Autophagy: The Intracellular Self-Degradation System Fighting against Diseases (2015)
  • Author(s): Tamotsu Yoshimori
  • Organizer: The 21st Annual Meeting of Japan Society of Gene Therapy
  • Place of Presentation: Osaka International Convention Center, Osaka
  • Year and Date: 2015-07-25
  • Int'l Joint Research / Invited
• [Presentation] Insights into Membrane Dynamics in Autophagy (2015)
  • Author(s): Tamotsu Yoshimori
  • Organizer: The Gordon Research Conference on Molecular Membrane Biology
  • Place of Presentation: Proctor Academy, Andover, NH, USA
  • Year and Date: 2015-07-16
  • Int'l Joint Research / Invited
• [Presentation] 細胞の守護者オートファジー：疾患に対抗する細胞内自己分解システム (2015)
  • Author(s): 吉森 保
  • Organizer: 第24回日本Cell Death学会学術集会
  • Place of Presentation: 大阪大学会館, 大阪
  • Year and Date: 2015-07-11
  • Invited
• [Presentation] Autophagy: the cellular Guardian Sustaining Life (2015)
  • Author(s): 吉森 保
  • Organizer: 第67回日本細胞生物学会大会 大会長企画シンポジウム
  • Place of Presentation: タワーホール船堀, 東京
  • Year and Date: 2015-07-01
  • Int'l Joint Research / Invited
• [Presentation] New Insights into Membrane Dynamics and Role of Autophagy (2015)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Keystone Symposia on Molecular and Cellular Biology “Autophagy (E6)”
  • Place of Presentation: Beaver Run Resort, Breckenridge, Colorado, USA
  • Year and Date: 2015-06-21
  • Int'l Joint Research / Invited
• [Presentation] 細胞の守護者オートファジー：分子機構と病態生理 (2015)
  • Author(s): 吉森 保
  • Organizer: 第118回日本小児科学会学術集会
  • Place of Presentation: 大阪国際会議場, 大阪
  • Year and Date: 2015-04-19
  • Invited
• [Presentation] Autophagy: Its Membrane Dynamics and Role in Suppression of Diseases (2015)
  • Author(s): Tamotsu Yoshimori
  • Organizer: British Society for Cell Biology & British Society for Developmental Biology Joint Spring Meeting
  • Place of Presentation: University of Warwick, Coventry, UK
  • Year and Date: 2015-04-13
  • Int'l Joint Research / Invited
• [Presentation] New Insights into Membrane Biogenesis and Targeting in Autophagy (2015)
  • Author(s): Tamotsu Yoshimori
  • Organizer: The 7th International Symposium on Autophagy
  • Place of Presentation: Smoky Willow Resort, Anhui, China
  • Year and Date: 2015-03-23
  • Invited
• [Presentation] Lysophagy: Damaged Lysosomes Are Selectively Eliminated by Autophagy (2015)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Gordon Research Conference on Lysosomal Diseases
  • Place of Presentation: Hotel Galvez, Galveston, USA
  • Year and Date: 2015-03-17
  • Invited
• [Presentation] Autophagy: The Intracellular Self-Degradation System Fighting against Diseases (2015)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Lorne Infection & Immunity Conference 2015
  • Place of Presentation: Mantra Erskine Beach Resort, Lorne, Australia
  • Year and Date: 2015-02-19
  • Invited
• [Presentation] New Insights into Membrane Biogenesis and Targeting in Autophagy (2014)
  • Author(s): Tamotsu Yoshimori
  • Organizer: 2014 Northeastern Asian Symposium on Autophagy
  • Place of Presentation: Westin Chosun Hotel, Busan, Korea
  • Year and Date: 2014-12-19
  • Invited
• [Presentation] 細胞の守護者オートファジー：分子機構と疾患との関わり (2014)
  • Author(s): 吉森 保
  • Organizer: 脳心血管抗加齢研究会２０１４ 併催：第４回 運動器抗加齢医学研究会／アンチエイジングフェスタ２０１４
  • Place of Presentation: 梅田スカイビル、大阪
  • Year and Date: 2014-12-07
  • Invited
• [Presentation] 細胞の守護者オートファジー：分子機構と疾患との関わり (2014)
  • Author(s): 吉森 保
  • Organizer: 第41回日本臓器保存生物医学会学術集会
  • Place of Presentation: 千里ライフサイエンスセンター、大阪
  • Year and Date: 2014-11-28
  • Invited
• [Presentation] オートファジーの膜動態：分子機構と疾患との関わり (2014)
  • Author(s): 吉森 保
  • Organizer: 第8回 オートファジー研究会、セッション５：分子機構と膜動態 (5) 生理・病態
  • Place of Presentation: シャトレーゼガトーキングダムサッポロ、札幌
  • Year and Date: 2014-11-11
  • Invited
• [Presentation] オートファジーの膜動態の分子機構とその破綻による病態の解明 (2014)
  • Author(s): 吉森 保
  • Organizer: 第87回 日本生化学会大会 平成26年度 第9回柿内三郎記念賞受賞講演
  • Place of Presentation: 国立京都国際会館、京都
  • Year and Date: 2014-10-15
  • Invited
• [Presentation] 細胞の守護者オートファジー：分子機構と疾患との関わり (2014)
  • Author(s): 吉森 保
  • Organizer: 第3回 川島腎カンファレンス
  • Place of Presentation: 内藤記念くすり博物館、岐阜
  • Year and Date: 2014-10-11
  • Invited
• [Presentation] Insights into membrane dynamics and role of mammalian autophagy (2014)
  • Author(s): Tamotsu Yoshimori
  • Organizer: The 38th Naito Conference on Molecule-based biological systems
  • Place of Presentation: シャトレーゼガトーキングダムサッポロ、札幌
  • Year and Date: 2014-10-09
  • Invited
• [Presentation] 細胞の守護者オートファジー：分子機構と疾患との関わり (2014)
  • Author(s): 吉森 保
  • Organizer: 第5回 Molecular Cardiovascular Conference Ⅱ キーノートレクチャー
  • Place of Presentation: 神戸ベイシェラトンホテル＆タワーズ、神戸
  • Year and Date: 2014-09-06
  • Invited
• [Presentation] 細胞の守護者オートファジー：分子機構と疾患との関わり (2014)
  • Author(s): 吉森 保
  • Organizer: 平成26年度 がん若手研究者ワークショップ
  • Place of Presentation: 蓼科グランドホテル滝の湯、長野
  • Year and Date: 2014-09-04
  • Invited
• [Presentation] オートファジーと疾患 (2014)
  • Author(s): 吉森 保
  • Organizer: 第19回 日本病態プロテアーゼ学会学術集会
  • Place of Presentation: 千里ライフサイエンスセンター、大阪
  • Year and Date: 2014-08-08
  • Invited
• [Presentation] 18 years of Autophagy: 生命を支える細胞内大規模分解系の理解を目指して (2014)
  • Author(s): 吉森 保
  • Organizer: 第10回近畿先天代謝異常症研究会
  • Place of Presentation: ホテルグランヴィア大阪、大阪
  • Year and Date: 2014-07-13
  • Invited
• [Book] Encyclopedia of Cell Biology, 1st Edition (Section editor for Volume 2: Organizational Cell Biology) (2015)
  • Author(s): Yoshimori Tamotsu 他
  • Total Pages: 852
  • Publisher: Academic Press
• [Book] プログレッシブ 生命科学（第1版） (2014)
  • Author(s): 吉森 保、岡正啓、米田悦啓、田中亀代次、西條將文、岩井一宏、菊池章、松本真司、岡村康司、山本浩靖、木原進士、松岡達、高木都、犬束歩、山中章弘、金井好克、磯谷綾子、伊川正人、古川貴久、戸田達史、他
  • Total Pages: 312
  • Publisher: 南山堂
• [Remarks] 研究室HP
  • URL: http://www.fbs.osaka-u.ac.jp/labs/yoshimori/
• [Remarks] 研究室ＨＰ
  • URL: http://www.fbs.osaka-u.ac.jp/labs/yoshimori/