| Budget Amount *help |
¥40,560,000 (Direct Cost: ¥31,200,000、Indirect Cost: ¥9,360,000)
Fiscal Year 2016: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2015: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2014: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
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| Outline of Final Research Achievements |
Imaging of meiotic chromatin: Using super-resolution microscopy, we found that meiotic cohesion-based chromatin structures are necessary for homologous chromosome pairing. We also found that chromatin decompaction occurs during meiotic DNA replication and that the decompaction requires acetylation of histone H4. In addition, we developed a new method to visualize histone modification in living cells.
Regulatory mechanisms of meiosis: We found that a component of the nuclear pore complex, Nup132, plays an important role in progression of meiosis, and that two APC/C activators regulate progression of meiosis. We also revealed that a nuclear membrane protein Lem2 augments centromeric heterochromatin in a nutrition-dependent manner.
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