Genetic and physiological factors that constitute cold adaptability in Japanese.

• Project/Area Number: 26251050
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied anthropology
• Research Institution: Kyushu University
• Principal Investigator: Watanuki Shigeki 九州大学, 芸術工学研究院, 教授 (00158677)
• Co-Investigator(Kenkyū-buntansha): 太田 博樹 北里大学, 医学部, 准教授 (40401228) ; 中山 一大 自治医科大学, 医学部, 講師 (90433581) ; 西村 貴孝 長崎大学, 医歯(薬)学総合研究科, 助教 (80713148) ; 星 良和 東海大学, 農学部, 教授 (70332088)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥39,130,000 (Direct Cost: ¥30,100,000、Indirect Cost: ¥9,030,000); Fiscal Year 2016: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000); Fiscal Year 2015: ¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000); Fiscal Year 2014: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
• Keywords: 生理的多型 / 遺伝的多型 / 体温調節 / 寒冷適応 / 遺伝子 / 環境 / 人類学 / 生理学 / 遺伝子多型 / 環境適応 / 生理人類学 / 低酸素

Outline of Final Research Achievements

We aimed to clear the relationship between genetic polymorphism and physiological polytypism of thermogenesis in Japanese. In this research, we focused on UCP1 genotype that affects human non-shivering thermogenesis (NST), and we examined the difference of NST among the UCP1 genotypes (rs1800592, etc.).
We showed that the degree of NST was significantly different among UCP1 genotypes. In addition, we found that the frequency of the haplotype with the highest NST was significantly correlated with latitudes and ambient temperature. Thus, the data provide the first evidence that the UCP1 genotype alters the efficiency of NST in humans, and likely supports the hypothesis that the UCP1 gene has been related to human cold adaptation. In conclusion, physiological polytypism of human cold adaptability was affected by genetic polymorphism, and our methodological approach such as using physiological, genetic, geographical data was progressive way of understanding human evolutionary history.

Research Products

• [Journal Article] Confounding effects of microbiome on the susceptibility of TNFSF15 to Crohn’s disease in the Ryukyu Islands (2017)
  • Author(s): S. Nakagome*, H. Chinen, A. Iraha, A. Hokama, Y. Takeyama, S. Sakisaka, T. Matsui, J.R. Kidd, K.K. Kidd, H.S. Said, W. Suda, H. Morita, M. Httori, T. Hanihara, R. Kimura, H. Ishida, J. Fujita, F. Kinjo, S. Mano, H. Oota
  • Journal Title: Human Genetics Volume: 136(4) Issue: 4 Pages: 387-397
  • DOI: 10.1007/s00439-017-1764-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] An approach to elucidate NBS1 function in DNA repair using frequent nonsynonymous polymorphism in wild medaka (Oryzias Latipes) populations (2017)
  • Author(s): K. Igarashi, J. Kobayashi, T. Katsumura, Y. Urushibara, K. Hida, T. Watanabe-Asaka, H. Oota, S. Oda and H. Mitani
  • Journal Title: PLOS ONE Volume: 12(1) Issue: 1 Pages: e0170006-e0170006
  • DOI: 10.1371/journal.pone.0170006
  • NAID: 120005980875
  • Peer Reviewed / Open Access
• [Journal Article] Influence of AHRR Pro189Ala polymorphism on kidney functions. Biosci Biotech Biochem. (2017)
  • Author(s): Nakayama K, Saito S, Watanabe K, Miyashita H, Nishijima F, Kamo Y, Tada K, Ishizuka S, Niwa T, Iwamoto S, Shimizu H
  • Journal Title: Biosci Biotech Biochem Volume: Published online Issue: 6 Pages: 1120-1124
  • DOI: 10.1080/09168451.2017.1292838
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] An adaptive variant of TRIB2, rs1057001, is associated with higher expression levels of thermogenic genes in human subcutaneous and visceral adipose tissues (2017)
  • Author(s): Nakayama K, Iwamoto S
  • Journal Title: J Phyiol Anthropol Volume: 36 Issue: 1 Pages: 16-16
  • DOI: 10.1186/s40101-017-0132-z
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The allele frequency of ALDH2*Glu504Lys and ADH1B*Arg47His for the Ryukyu islanders and their history of expansion among East Asians (2016)
  • Author(s): K.Koganebuchi, K. Haneji, T. Toma, K. Joh, H.n Soejima, K. Fujimoto, H. Ishida, M. Ogawa, T. Hanihara, S. Harada, S. Kawamura and H. Oota
  • Journal Title: American Journal of Human Biology Volume: 29(2)
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A comparative study on the regulatory region of the PERIOD1 gene among diurnal/Nocturnal primates (2016)
  • Author(s): T. Katsumura, Y. Fukuyo, S. Kawamura, H. Oota
  • Journal Title: Journal of Physiological Anthropology Volume: 35(1) Pages: 21-21
  • Peer Reviewed / Open Access
• [Journal Article] In vivo 3D analysis of systemic effects after local heavy-ion beam irradiation in an animal model (2016)
  • Author(s): Nagata K, Hashimoto C, Watanabe-Asaka T, Itoh K, Yasuda T, Ohta K, Oonishi H, Igarashi K, Suzuki M, Funayama T, Kobayashi Y, Nishimaki T, Katsumura T, Oota H, Ogawa M, Oga A, Ikemoto K, Itoh H, Kutsuna N, Oda S, and Mitani H
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 28691-28691
  • DOI: 10.1038/srep28691
  • Peer Reviewed / Open Access
• [Journal Article] Transgenic medaka that overexpress growth hormone have a skin color that does not indicate the activation or inhabition of somatolactin-α signal (2016)
  • Author(s): R. Komine, T. Nishimaki, T. Kimura, H. Oota, K. Naruse, N. Homma, S. Fukamachi*
  • Journal Title: GENE Volume: 584 Issue: 1 Pages: 38-46
  • DOI: 10.1016/j.gene.2016.02.046
  • Peer Reviewed / Open Access
• [Journal Article] ZNF70, a novel ILDR2-interacting protein, contributes to the regulation of HES1 gene expression (2016)
  • Author(s): Watanabe K, Nakayama K, Ohta S, Tago K, Boonvisut S, Millings EJ, Fischer SG, LeDuc CA, Leibel RL, Iwamoto S.
  • Journal Title: Biochem Biophys Res Commun Volume: 477 Issue: 4 Pages: 712-716
  • DOI: 10.1016/j.bbrc.2016.06.124
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Replication analysis of genetic association of the NCAN-CILP2 region with plasma lipid levels and non-alcoholic fatty liver disease in Asian and Pacific ethnic groups. (2016)
  • Author(s): Boonvisut S, Nakayama K, Makishima S, Watanabe K, Miyashita H, Lkhagvasuren M,Kagawa Y, Iwamoto S
  • Journal Title: Lipids Health Dis. Volume: 15 Issue: 1 Pages: 8-8
  • DOI: 10.1186/s12944-016-0181-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Relationship between mitochondrial haplogroup and physiological responses to hypobaric hypoxia (2016)
  • Author(s): Motoi M, Nishimura T, Egashira Y, Kishida F, Watanuki S
  • Journal Title: J Physiol Anthropol Volume: 35 Issue: 1 Pages: 12-12
  • DOI: 10.1186/s40101-016-0094-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Nonthermal sensory input and altered human thermoregulation: effects of visual information depicting hot or cold environments (2015)
  • Author(s): Takakura J, Nishimura T, Choi D, Egashira Y, Watanuki S
  • Journal Title: International Journal of Biometeorology Volume: 59 Issue: 10 Pages: 1453-1460
  • DOI: 10.1007/s00484-015-0956-3
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The role of TRIB1 in lipid metabolism; from genetics to pathways. (2015)
  • Author(s): Iwamoto S, Boonvisut S, Makishima S, Ishizuka Y, Watanabe K, Nakayama K
  • Journal Title: Biochem Soc Trans. Volume: 43 Issue: 5 Pages: 1063-1068
  • DOI: 10.1042/bst20150094
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Sin3A-associated protein, 18 kDa, a novel binding partner of TRIB1, regulates MTTP expression. (2015)
  • Author(s): Makishima S, Boonvisut S, Ishizuka Y, Watanabe K, Nakayama K, Iwamoto S.
  • Journal Title: J Lipid Res. Volume: 56 Issue: 6 Pages: 1145-1152
  • DOI: 10.1194/jlr.m057802
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] ミトコンドリアDNA解析から推定する香川県メダカの集団史/ Population history of medaka (Oryzias Latipes) in Kagawa Prefecture inferred from mitochondrial DNA analysis (2015)
  • Author(s): 山下佳那、勝村啓史*、尾田正二、今井正、吉浦康寿、太田博樹
  • Journal Title: 地域自然史と保全 Volume: -
  • Peer Reviewed
• [Journal Article] Meiotic recombination couFnteracts male-biased mutation (male-driven evolution) (2015)
  • Author(s): S. Mawaribuchi, M. Ito, M. Ogata, H. Oota, T. Katsumura, N. Yakamatsu and I. Miura
  • Journal Title: Proceedings of the Royal Society B Volume: 283 Pages: 1823-1823
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Biochemical characterization of medaka (Oryzias latipes) transgulutaminases, (2015)
  • Author(s): A. Kikuta, E. Furukara, R. Ogawa, N. Suganuma, M. Saitoh, T. Nishimaki, T. Katsumura, H. Oota, T. Kawamoto, H. Tatsukawa, H. Hashimoto and K. Hitomi
  • Journal Title: PLOS ONE Volume: 10（12）
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] “How ‘Circumpolar’ is Ainu music? Musical and Genetic Perspective on the history of the Japanese Archipelago.” (2015)
  • Author(s): PE. Savage, H. Matsumae, H. Oota, M. Stoneking, T. Currie, A. Tajima, M. Gillan and S. Brown
  • Journal Title: Ethnomusicology Forum Volume: 24(3) Issue: 3 Pages: 443-467
  • DOI: 10.1080/17411912.2015.1084236
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Model-based verification of hypotheses on the origin of modern Japanese revisited by Bayesian inference based on genome-wide SNP data (2015)
  • Author(s): Nakagome S., Sato T., Ishida H., Hanihara T., Yamaguchi T., Kimura R., Mano S., Oota H., The Asian DNA Repository Consortium
  • Journal Title: Molecular Biology and Evolution Volume: in press Issue: 6 Pages: 1-11
  • DOI: 10.1093/molbev/msv045
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Seasonal variation of non-shivering thermogenesis (NST) during mild cold exposure (2015)
  • Author(s): Nishimura T, Motoi M, Egashira Y, Choi D, Aoyagi K, Watanuki S.
  • Journal Title: Journal of Physiological Anthropology Volume: 34 Issue: 1 Pages: 11-11
  • DOI: 10.1186/s40101-015-0051-9
  • NAID: 120006987089
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 現代日本人の生理的多型を構成する遺伝要因の検証 (2015)
  • Author(s): 西村貴孝,綿貫茂喜
  • Journal Title: 日本生理人類学会誌 Volume: 20 Pages: 39-44
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Seasonal effects of the UCP3 and the RPTOR gene polymorphisms on obesity traits in Japanese adults. (2014)
  • Author(s): Nakayama K, Miyashita H, Iwamoto S
  • Journal Title: Journal of Physiological Anthropology Volume: 33 Issue: 1 Pages: 38-38
  • DOI: 10.1186/1880-6805-33-38
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Common variants of GIP are associated with visceral fat accumulation in Japanese adults. (2014)
  • Author(s): Nakayama K, Watanabe K, Boonvisut S, Makishima S, Miyashita H, Iwamoto S.
  • Journal Title: Am J Physiol Gastrointest Liver Physiol. Volume: 307 Issue: 11 Pages: G1108-G1114
  • DOI: 10.1152/ajpgi.00282.2014
  • Peer Reviewed / Open Access
• [Journal Article] 健診集団試料を用いたMLXIPL Gln241His多型の適応的意義の検討 (2014)
  • Author(s): 中山 一大, 宮下 洋, 岩本禎彦
  • Journal Title: 日本生理人類学会誌 Volume: 19 Pages: 63-67
  • NAID: 110009818792
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Illusory Self-Motion (Vection) May Be Inhibited by Hypobaric Hypoxia (2014)
  • Author(s): Nishimura Ｔ, Seno T, Motoi M, Watanuki S
  • Journal Title: Aviation,Space,and Enviromental Medicine Volume: 85 Pages: 504-508
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Relationship between mitochondrial haplogroup and seasonal changes of physiological responses to cold. (2014)
  • Author(s): Nishimura T, Watanuki S.
  • Journal Title: Journal of Physiological Anthropology Volume: 33 Issue: 1 Pages: 27-27
  • DOI: 10.1186/1880-6805-33-27
  • NAID: 120006986366
  • Peer Reviewed / Open Access
• [Journal Article] ヒトの生理値から集団を科学する : 人類の寒冷適応と産熱機能の生理的多型 (2014)
  • Author(s): 西村 貴孝
  • Journal Title: 日本生理人類学会誌 Volume: 19 Pages: 269-273
  • Peer Reviewed / Open Access
• [Journal Article] Correspondence: Human genetic research, race, ethnicity and the labeling of populations: recommendations based on an interdisciplinary workshop in Japan (2014)
  • Author(s): Takezawa, Y., Kato, K., Oota. H., Caulfield, T., Fujimoto, A., Honda, F., Kamatani, N., Kawamura, S., Kawashima, K., Kimura, R., Matsumae, H., Saito, A., Savage, P. E., Seguchi, N., Shimizu, K., Terao, S., Yamaguchi-Kabata, Y., Yasukouchi, A., Yoneda, M. and Tokunaga, K.
  • Journal Title: BMC Medical Ethics Volume: 15 Issue: 1 Pages: 33-33
  • DOI: 10.1186/1472-6939-15-33
  • Peer Reviewed / Open Access
• [Journal Article] Genome-Wide SNP Analysisi RevealsPopulation Structure and Demographic History of the Ryukyu Islanders in the Southern Part of the Japanese Archipelago (2014)
  • Author(s): T. Sato, S. Nakagome, C. Watanabe, K. Yamaguchi, A. Kawaguchi, K. Koganebuchi, K. Haneji, T. Yamaguchi, T. Hanihara, K. Yamamoto, H. Ishida, S. Mano, R. Kimura, H. Oota
  • Journal Title: Ｍｏｌｅｃｕｌａｒ Ｂｉｏｌｏｇｙ ａｎｄ Ｅｖｏｌｕｔｉｏｎ Volume: 31 Pages: 2929-2940
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Natural allelic variations of xenobiotic metabolizing enzymes affect sexual dimorphism in Oryzias latipes (2014)
  • Author(s): T. Katsumura, S. Oda, S. Nakagome, T. Hanihara, H. Kataoka, H. Mitani, S. Kawamura, H. Oota
  • Journal Title: Proceedings of the Royal Society B: Biological Sciences Volume: 281 Pages: 1797-1797
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Ecology of and control measures against Philometroides cyprini (1970)
  • Author(s): 西槙俊之、勝村啓史、尾田正二*、小賀厚徳、小川元之、太田博樹
  • Journal Title: Fish Pathology Volume: 5 Issue: 1 Pages: 1-3
  • DOI: 10.3147/jsfp.5.1
  • NAID: 130000855013
  • ISSN: 0388-788X, 1881-7335
  • Peer Reviewed / Open Access
• [Presentation] A trial for reconstructing human population history in the Japanese archipelago ～ through the simulation based on genome-wide data and ancient DNA analyses (2017)
  • Author(s): H.Oota
  • Organizer: The Genome Evolution at Mishima
  • Place of Presentation: Mishima, Japan
  • Year and Date: 2017-03-27
  • Int'l Joint Research / Invited
• [Presentation] 性皮膨張メカニズムの解明に向けて～ニホンザルのメンス前血中ホルモン濃度変動と相関する血球の発現変動遺伝子の検出～ (2017)
  • Author(s): 太田博樹
  • Organizer: 第46回ホミニゼーション研究会「性的二型とホミニゼーション 家族と育児・養育の霊長類基盤」
  • Place of Presentation: 犬山
  • Year and Date: 2017-03-24
  • Invited
• [Presentation] ゲノムから見た日本列島人ー多様性の起源と病気についてー (2017)
  • Author(s): 太田博樹
  • Organizer: 未来バイオ勉強会企画「骨から診た日本人の起源と健康」（バイオインダストリー協会）
  • Place of Presentation: 東京
  • Year and Date: 2017-02-28
  • Invited
• [Presentation] ゲノムデータから人類史を読み解く方法 何がわかって何はわからないか (2016)
  • Author(s): 太田博樹
  • Organizer: 2016年度西洋史研究会大会 シンポジウム「ゲノム研究は歴史を変える 西ユーラシアの農耕ー牧畜・移動ー定住研究の現在」
  • Place of Presentation: 宮城
  • Year and Date: 2016-11-20
  • Invited
• [Presentation] 農耕・牧畜成立に関連するゲノム多様性－現代人の疾患感受性との関連で－ (2016)
  • Author(s): 中山一大
  • Organizer: 2016年度西洋史研究会大会
  • Place of Presentation: 東北大学（宮城県仙台市）
  • Year and Date: 2016-11-20
  • Invited
• [Presentation] 遊牧民族と農耕民族のゲノムワイドメチル化パターンの比較 (2016)
  • Author(s): 中山一大、渡邉和寿、Munkhtulga Lkhagvasuren, Sukhumsirichart Wasana, 香川靖雄、岩本禎彦
  • Organizer: 日本生理人類学会第74回大会
  • Place of Presentation: 和倉温泉観光会館（石川県七尾市）
  • Year and Date: 2016-10-23
• [Presentation] ゲノム人類学から見た双子研究 (2016)
  • Author(s): 太田博樹
  • Organizer: 日本生理人類学会第74回大会 シンポジウム「遺伝を通してヒトを理解する」
  • Place of Presentation: 石川
  • Year and Date: 2016-10-22
  • Invited
• [Presentation] ゲノムワイドSNP情報から表現型へのアプローチ：ヒトでの研究例を中心に (2016)
  • Author(s): 中山一大
  • Organizer: 日本比較臨床医学会第47回学術集会シンポジウム
  • Place of Presentation: 獣医生命科学大学（東京都武蔵野市）
  • Year and Date: 2016-10-16
  • Invited
• [Presentation] 愛知県渥美半島・伊川津貝塚遺跡出土縄文人骨のゲノム解析（予報） (2016)
  • Author(s): 覚張隆史
  • Organizer: 第70会日本人類学会大会
  • Place of Presentation: 新潟
  • Year and Date: 2016-10-08
• [Presentation] 古代ゲノム解析への応用に向けたBACダブルキャプチャー法の開発 (2016)
  • Author(s): 小金渕佳江
  • Organizer: 第70会日本人類学会大会
  • Place of Presentation: 新潟
  • Year and Date: 2016-10-08
• [Presentation] CADM2-VGLL3遺伝子領域に見出されたモンゴル人特異的な正の自然選択の年代推定 (2016)
  • Author(s): 中山一大、渡邉和寿、岩本禎彦、大橋順、
  • Organizer: 第70回日本人類学会大会
  • Place of Presentation: NGS学生総合プラザSTEP（新潟県新潟市）
  • Year and Date: 2016-10-08
• [Presentation] The preliminary report for the NGS analyses of the Jomon genome from the western part of the Japanese archipelago (2016)
  • Author(s): 太田博樹
  • Organizer: 日本進化学会 第18回大会 ワークショップ6「ヒトのゲノム進化」
  • Place of Presentation: 東京
  • Year and Date: 2016-08-26
  • Invited
• [Presentation] UCP1 genotype changes non-shivering thermogenesis under mild cold environment (2016)
  • Author(s): Nishimura T, Katsumura T, Motoi M, Oota H, Watanuki S
  • Organizer: Conference of "Modernization and Health in the Asia-Pacific Region"
  • Place of Presentation: Hilo, Hawaii, USA
  • Year and Date: 2016-08-19
  • Int'l Joint Research
• [Presentation] The relationship between 5-HTTLPR and Event-related Potentials (ERPs) during affective picture processing of different objects. (2016)
  • Author(s): Motoi M, Kishida F, Egashira Y, Minote N, Watanuki S
  • Organizer: Conference of "Modernization and Health in the Asia-Pacific Region"
  • Place of Presentation: Hilo, Hawaii, USA
  • Year and Date: 2016-08-19
  • Int'l Joint Research
• [Presentation] The preliminary report for the deep sequencing of the prehistoric Jomon genome from the Japanese archipelago (2016)
  • Author(s): H. Oota
  • Organizer: The Society for Molecular Biology and Evolution, Annual Meeting
  • Place of Presentation: Gold Coast, Australia
  • Year and Date: 2016-07-03
  • Int'l Joint Research
• [Presentation] 低酸素環境下における事象関連電位とミトコンドリアDNAハプロタイプの関連 (2016)
  • Author(s): 本井碧, 黒田知宏, 岸田文, 西村貴孝, 綿貫茂喜
  • Organizer: 日本生理人類学会第73回大会
  • Place of Presentation: 大阪
  • Year and Date: 2016-06-04
• [Presentation] ゲノムワイドDNAメチル化パターンの多様性：遊牧集団と農耕集団の比較 (2016)
  • Author(s): 中山一大、渡邉和寿、Lkhaguvasuren Munkhtulga, Wasana Sukhumsirichart, 香川靖雄、岩本禎彦
  • Organizer: 第70回日本栄養・食糧学会大会
  • Place of Presentation: 武庫川女子大学（兵庫県武庫川市）
  • Year and Date: 2016-05-14
• [Presentation] Detection of Population Specific Signals of Positive Selection in Mongolians (2016)
  • Author(s): Nakayama K, Ohash J, Munkhtulga L, Iwamoto S
  • Organizer: The 13th International Congress of Human Genetics
  • Place of Presentation: 京都国際会館（京都府京都市）
  • Year and Date: 2016-04-05
  • Int'l Joint Research
• [Presentation] Identification of Genetic Variants for Visceral Fat Accumulation in Japanese. (2015)
  • Author(s): Nakayama K
  • Organizer: The 12th International Congress of Physiological Anthropology
  • Place of Presentation: 千葉市
  • Year and Date: 2015-10-29
  • Int'l Joint Research / Invited
• [Presentation] 寒冷適応に関わるUCP1 遺伝子型間のヒトにおける熱産生反応の違い (2015)
  • Author(s): 西村貴孝，勝村啓史，本井碧，太田博樹，綿貫茂喜
  • Organizer: 第69回日本人類学会大会
  • Place of Presentation: 東京都港区
  • Year and Date: 2015-10-10
• [Presentation] 高密度SNPジェノタイピングによるモンゴル人特異的な自然選択の検出 (2015)
  • Author(s): 中山一大、大橋順、ルハグワスレン・ムンフトルガ、岩本禎彦
  • Organizer: 第69回日本人類学会大会
  • Place of Presentation: 東京都港区
  • Year and Date: 2015-10-10
• [Presentation] 古代ゲノムシークエンシングのための技術改良 (2015)
  • Author(s): 太田博樹、覚張隆史、ライアン・シュミット、勝村啓史、松前ひろみ、埴原恒彦、 小川元之、柴田弘紀、佐伯和信、分部哲秋、弦本敏行、佐藤丈寛、木村亮介、石田肇
  • Organizer: 第69回日本人類学会大会
  • Place of Presentation: 東京都港区
  • Year and Date: 2015-10-10
• [Presentation] 渥美半島における縄文時代人骨古代DNA分析 (2015)
  • Author(s): 覚張隆史、ライアン・シュミット、松前ひろみ、勝村啓史、太田博樹、埴原恒彦、小川元之、柴田弘紀、茂原信生、近藤修、米田穣、増山禎之、設楽博己、山田康弘
  • Organizer: 第69回日本人類学会大会
  • Place of Presentation: 東京都港区
  • Year and Date: 2015-10-10
• [Presentation] ウクライナ・ヴァティーバ洞穴人骨の古遺伝学的解析 (2015)
  • Author(s): ライアン・W・シュミット、覚張隆史、小川元之、太田博樹、松前ひろみ、柴田弘紀 ジョーダン・カーステン、ミハイオ・ソハトスキー
  • Organizer: 第69回日本人類学会大会
  • Place of Presentation: 東京都港区
  • Year and Date: 2015-10-10
• [Presentation] 次世代シーケンサーによる北海道アイヌの全ゲノム配列解析 (2015)
  • Author(s): 松前ひろみ、小金渕佳江、木村亮介、田嶋敦、河村正二、清水健太郎、太田博樹、
  • Organizer: 第69回日本人類学会大会
  • Place of Presentation: 東京都港区
  • Year and Date: 2015-10-10
• [Presentation] 骨有機質残存状況の洞窟遺跡と開地遺跡における比較 (2015)
  • Author(s): 覚張隆史、太田博樹、米田穣
  • Organizer: 第69回日本人類学会大会
  • Place of Presentation: 東京都港区
  • Year and Date: 2015-10-10
• [Presentation] ニホンザルの血中エストロゲンおよびプロゲステロン濃度変化に伴う 血球の遺伝子発現変化のRNA-seq によるプロファイリング (2015)
  • Author(s): 勝村啓史、太田博樹
  • Organizer: 第69回日本人類学会大会
  • Place of Presentation: 東京都港区
  • Year and Date: 2015-10-10
• [Presentation] 東アジア遺跡出土馬の古DNA分析における方法論的改善とその応用 (2015)
  • Author(s): 覚張隆史、石毛太一郎、菊池大樹、丸山真史、曹龍、王煒;林、鶴間和幸、米田穣、太田博樹、河野友宏、半澤恵
  • Organizer: 第69回日本人類学会大会
  • Place of Presentation: 東京都港区
  • Year and Date: 2015-10-10
• [Presentation] Genetics of fat distribution and metabolism: Perspectives from human evolution (2015)
  • Author(s): Nakayama K
  • Organizer: International Symposium on Human Adaptation to Environment and Whole-body Coordination 2015
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2015-03-15
  • Invited
• [Presentation] アジア・オセアニア人における代謝特性の民族差の理解を目指したゲノムワイドSNP研究 (2014)
  • Author(s): 中山 一大、大橋順、香川靖雄、岩本禎彦
  • Organizer: 第68回日本人類学会大会
  • Place of Presentation: 静岡県浜松市
  • Year and Date: 2014-11-01
• [Presentation] Genetic variation of the Tribbles family and metabolic syndrome (2014)
  • Author(s): Nakayama K
  • Organizer: The 11the International Nikko Symposium
  • Place of Presentation: 栃木県下野市
  • Year and Date: 2014-10-30
• [Presentation] GIPおよびGIPRの遺伝的多型は日本人成人の内臓脂肪蓄積と関連する (2014)
  • Author(s): 中山一大、宮下洋、渡邉和寿、巻島咲穂、Boonvisut Supichay、岩本禎彦
  • Organizer: 第３５回日本肥満学会
  • Place of Presentation: 宮崎県宮崎市
  • Year and Date: 2014-10-25
• [Presentation] The whole mitochondrial DNA genome of an unknown medaka population from western Kanagawa(Poster) (2014)
  • Author(s): T. Katsumura, H. Oota
  • Organizer: 20th Japanese Medaka and Zebrafish Meeting
  • Place of Presentation: 東京
  • Year and Date: 2014-09-20 – 2014-09-21
• [Presentation] A histopathological study of Medaka (Oryzias latipes) with possible inflectional Disease(Poster) (2014)
  • Author(s): T. Nishimaki, T. Katsumura, S. Oda, A. Oga, I. Okayasu, T. Hanihara, H. Oota
  • Organizer: 20th Japanese Medaka and Zebrafish Meeting
  • Place of Presentation: 東京
  • Year and Date: 2014-09-20 – 2014-09-21
• [Presentation] Challenges to Ancient DNA Analysis in Japan: bioarcheological remains from high temperature, high humidity and an acidic soil environment (2014)
  • Author(s): H. Matsumae, T. Gakuhari, T. Katsumura, R. Schmidt, K. Koganebuchi, H. Oota
  • Organizer: 6th International Symposium on Biomolecular Archaeology
  • Place of Presentation: Basel, Switzerland
  • Year and Date: 2014-08-27 – 2014-08-30
• [Presentation] 化石標本とライフサイエンスデータを統合する進化史研究の基盤データベースの開発 (2014)
  • Author(s): 松前ひろみ、仲里猛留、大田達郎、太田博樹
  • Organizer: 日本進化学会第１６回大阪大会
  • Place of Presentation: 大阪
  • Year and Date: 2014-08-21 – 2014-08-24
• [Presentation] 薬物代謝酵素の遺伝的多型がメダカの性的二型に与える影響とその進化的考察 (2014)
  • Author(s): 勝村啓史、尾田正二、三谷啓志、河村正二、太田博樹
  • Organizer: 日本進化学会第１６回大阪大会
  • Place of Presentation: 大阪
  • Year and Date: 2014-08-21 – 2014-08-24
• [Presentation] 日本列島ヒト集団におけるモヤモヤ病感受性遺伝子RNF213の遺伝的多様性の検討 (2014)
  • Author(s): 小金渕佳江、石崎直也、河村正二、木村亮介、石田肇、城圭一郎、副島英伸、藤本一真、佐藤公彦、安井美江、隈部俊宏、藤井清孝、秋山辰穂、埴原恒彦、太田博樹
  • Organizer: 日本進化学会第１６回大阪大会
  • Place of Presentation: 大阪
  • Year and Date: 2014-08-21 – 2014-08-24
• [Presentation] ヒトの生理値から集団を科学する (2014)
  • Author(s): 西村 貴孝
  • Organizer: 日本生理人類学会第70会大会
  • Place of Presentation: 福岡
  • Year and Date: 2014-06-21 – 2014-06-22
  • Invited
• [Presentation] メラトニン抑制に関する生理的多型と時計遺伝子PERIOD2多型との関係及びその適応的意義の考察 (2014)
  • Author(s): 秋山辰穂、勝村啓史、中込滋樹、城圭一郎、副島英伸、藤本一真、木村亮介、石田肇、埴原恒彦、樋口重和、太田博樹
  • Organizer: 第70回日本生理人類学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2014-06-21 – 2014-06-22
• [Presentation] モンゴル人と東アジア農耕民族の代謝特性の解明を目指したゲノム人類学研究 (2014)
  • Author(s): 中山 一大、大橋 順、Munkhtulga Lkhagvasuren、宮下 洋、岩本 禎彦
  • Organizer: 第68回日本栄養・食糧学会大会 
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2014-05-31
• [Presentation] A genetic polymorphism of the PER2 gene associates with physiological polytypisms for light sensitivity in human (2014)
  • Author(s): T. Akiyama, S. Higuchi, H. Oota
  • Organizer: The International union of anthropological and ethnological sciences inter-Congress
  • Place of Presentation: 千葉
  • Year and Date: 2014-05-15 – 2014-05-18
• [Book] 性的二型の分子進化学的理解ーメダカの尻鰭と性ステロイドホルモンー、pp156-173. ホルモンから見た生命現象と進化シリーズIII, 成長・成熟・性決定 伊藤道彦、高橋明義（共編） (2016)
  • Author(s): 勝村啓史、太田博樹
  • Total Pages: 183
  • Publisher: 裳華房
• [Book] 人間科学の百科事典 (2015)
  • Author(s): 西村貴孝他（日本生理人類学会編集）
  • Total Pages: 700
  • Publisher: 丸善出版