Molecular basis of the complex morphogenesis of a rare actinomycete
| Project/Area Number |
26252010
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Ohnishi Yasuo 東京大学, 大学院農学生命科学研究科(農学部), 教授 (90292789)
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| Co-Investigator(Renkei-kenkyūsha) |
Takeaki Tezuka 東京大学, 大学院農学生命科学研究科, 助教 (80646414)
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| Project Period (FY) |
2014-06-27 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥40,170,000 (Direct Cost: ¥30,900,000、Indirect Cost: ¥9,270,000)
Fiscal Year 2016: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2015: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2014: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
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| Keywords | 放線菌 / 希少放線菌 / 形態分化 / 遺伝子発現制御 / 胞子嚢 / べん毛 / 転写因子 / 菌糸 / ChIP-seq / mRNA-seq / 微生物 / 運動性胞子 |
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| Outline of Final Research Achievements |
The rare actinomycete Actinoplanes missouriensis shows complex morphological differentiation. A. missouriensis is a filamentous bacterium and produces terminal sporangia that include hundreds of flagellated spores. Upon contact with water, the spores are released from the sporangia by dehiscence and swim rapidly for a short period of time until they find niches for germination. In this research project, I studied the molecular basis of its complex morphogenesis by several approaches and obtained new knowledge of the fundamental issues of cell biology, such as “sleeping and awakening of cells” and “regulation of cell motility”.
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Report
(4 results)
Research Products
(26 results)
