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Pathology of Gastric Cancer for Precision Medicine

Research Project

Project/Area Number 26253021
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionThe University of Tokyo

Principal Investigator

Fukayama Masashi  東京大学, 大学院医学系研究科(医学部), 教授 (70281293)

Research Collaborator USHIKU Tetsuo  
USHIKU Aya  
ABE Hiroyuki  
KUNITA Akiko  
Project Period (FY) 2014-06-27 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥38,610,000 (Direct Cost: ¥29,700,000、Indirect Cost: ¥8,910,000)
Fiscal Year 2018: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2017: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2016: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2015: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2014: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Keywords胃癌 / 病理学 / 分子型 / 遺伝子異常 / 癌微小環境 / 癌幹細胞 / 多様性 / 個別化医療 / 間質間葉系細胞 / 幹細胞 / 間葉系幹細胞
Outline of Final Research Achievements

To promote precision medicine of gastric carcinoma (GC), we studied pathological characteristics of four molecular subtypes of GC (EBV-positive GC, microsatellite instable GC, chromosome instable GC, and genomically stable GC), which were recently proposed by the international genome research group (TCGA).
The mechanisms by which cancer cells escape from the host immune system have been clarified in EBV-positive GC (viral copy numbers, expression and gene amplification of PD-L1, regulation of dendritic cells via exosomes and maintenance of cancer stemness were studied) and in microsatellite instable GC (intramucosal multi-clonality and lost expression of HLA class I).
Chromosome instable GC and genomically stable GC respectively include potentially distinct subgroups. We identified and characterized the following subgroups, fetal gastrointestinal epithelium-like GC in the former, and RHOA-mutated GC and CLDN18-ARHGAP fusion gene-positive GC in the latter subtype of GC.

Academic Significance and Societal Importance of the Research Achievements

胃癌の発生にはピロリ菌の慢性感染,慢性炎症が重要な役割を果たしているが,発生する胃癌は多様である.従来,組織像から腸型,びまん型に二大別して論じてきたが,胃癌個別化医療という観点からは不十分であった.本研究では分子機序に基づく病理学により,分子型の染色体不安定性胃癌の中に胎児消化管上皮類似癌,ゲノム安定性胃癌の中にRhoA遺伝子変異癌,融合遺伝子陽性癌というサブグループを同定し,特質を解明した.またEBV陽性胃癌,マイクロサテライト不安定性胃癌では免疫回避機構を明らかにした.
本研究により,分子型による胃癌病理学の有効性を示し,個別化医療の基盤となる胃癌病理学研究の方向性を定めることができた.

Report

(6 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (56 results)

All 2019 2018 2017 2016 2015 2014 Other

All Journal Article (23 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 21 results,  Open Access: 11 results,  Acknowledgement Compliant: 6 results) Presentation (27 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results) Book (3 results) Remarks (3 results)

  • [Journal Article] Viral loads correlate with upregulation of PD-L1 and worse patient prognosis in Epstein?Barr Virus-associated gastric carcinoma2019

    • Author(s)
      Nakayama Atsuhito、Abe Hiroyuki、Kunita Akiko、Saito Ruri、Kanda Teru、Yamashita Hiroharu、Seto Yasuyuki、Ishikawa Shumpei、Fukayama Masashi
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 1 Pages: e0211358-e0211358

    • DOI

      10.1371/journal.pone.0211358

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Initial and crucial genetic events in intestinal-type gastric intramucosal neoplasia2019

    • Author(s)
      Rokutan Hirofumi、Abe Hiroyuki、Nakamura Hiromi、Ushiku Tetsuo、Arakawa Erika、Hosoda Fumie、Yachida Shinichi、Tsuji Yosuke、Fujishiro Mitsuhiro、Koike Kazuhiko、Totoki Yasushi、Fukayama Masashi、Shibata Tatsuhiro
    • Journal Title

      The Journal of Pathology

      Volume: 247 Issue: 4 Pages: 494-504

    • DOI

      10.1002/path.5208

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD47 expression in Epstein-Barr virus-associated gastric carcinoma: coexistence with tumor immunity lowering the ratio of CD8+/Foxp3+ T cells2018

    • Author(s)
      Abe Hiroyuki、Saito Ruri、Ichimura Takashi、Iwasaki Akiko、Yamazawa Sho、Shinozaki-Ushiku Aya、Morikawa Teppei、Ushiku Tetsuo、Yamashita Hiroharu、Seto Yasuyuki、Fukayama Masashi
    • Journal Title

      Virchows archiv

      Volume: 印刷中 Issue: 4 Pages: 643-651

    • DOI

      10.1007/s00428-018-2332-2

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gastritis-Infection-Cancer Sequence of Epstein-Barr Virus-Associated Gastric Cancer.2018

    • Author(s)
      Fukayama M, Kunita A, Kaneda A
    • Journal Title

      Adv Exp Med Biol.

      Volume: 1045 Pages: 437-457

    • DOI

      10.1007/978-981-10-7230-7_20

    • ISBN
      9789811072291, 9789811072307
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synergistic Cytotoxic Effect on Gastric Cancer Cells of an Immunotoxin Cocktail in Which Antibodies Recognize Different Epitopes on CDH172018

    • Author(s)
      Kusano-Arai O, Iwanari H, Kudo S, Akiba H, Matsusaka K, Kaneda A, Fukayama M, Tsumoto K, Hamakubo T.
    • Journal Title

      Monoclonal Antibodies in Immunodiagnosis and Immunotherapy

      Volume: 37 Issue: 1 Pages: 1-11

    • DOI

      10.1089/mab.2017.0043

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MicroRNA-21 in cancer-associated fibroblasts supports lung adenocarcinoma progression.2018

    • Author(s)
      Kunita A, Morita S, Irisa TU, Goto A, Niki T, Takai D, Nakajima J, Fukayama M
    • Journal Title

      Sci Rep.

      Volume: 8 Issue: 1 Pages: 1276-1288

    • DOI

      10.1038/s41598-018-27128-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Frequent <i>CLDN18-ARHGAP</i> fusion in highly metastatic diffuse-type gastric cancer with relatively early onset2018

    • Author(s)
      Tanaka Atsushi、Ishikawa Shumpei、Ushiku Tetsuo、Yamazawa Sho、Katoh Hiroto、Hayashi Akimasa、Kunita Akiko、Fukayama Masashi
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 50 Pages: 29336-50

    • DOI

      10.18632/oncotarget.25464

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunogenetic Profiling for Gastric Cancers Identifies Sulfated Glycosaminoglycans as Major and Functional B Cell Antigens in Human Malignancies.2017

    • Author(s)
      Katoh H, Komura D, Konishi H, Suzuki R, Yamamoto A, Kakiuchi M, Sato R, Ushiku T, Yamamoto S, Tatsuno K, Oshima T, Nomura S, Seto Y, Fukayama M, Aburatani H, Ishikawa S.
    • Journal Title

      Cell Rep

      Volume: 20 Issue: 5 Pages: 1073-1087

    • DOI

      10.1016/j.celrep.2017.07.016

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gastric Cancer With Primitive Enterocyte Phenotype: An Aggressive Subgroup of Intestinal-type Adenocarcinoma.2017

    • Author(s)
      Yamazawa S, Ushiku T, Shinozaki-Ushiku A, Hayashi A, Iwasaki A, Abe H, Tagashira A, Yamashita H, Seto Y, Aburatani H, Fukayama M.
    • Journal Title

      Am J Surg Pathol

      Volume: 41 Issue: 7 Pages: 989-997

    • DOI

      10.1097/pas.0000000000000869

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 胚細胞腫瘍に類似した体細胞腫瘍の組織発生と分化2017

    • Author(s)
      牛久 哲男, 山澤 翔, 深山 正久
    • Journal Title

      病理と臨床

      Volume: 35 Pages: 1126-1132

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Overexpression and gene amplification of PD-L1 in cancer cells and PD-L1(+) immune cells in Epstein-Barr virus-associated gastric cancer: the prognostic implications.2017

    • Author(s)
      Saito R, Abe H, Kunita A, Yamashita H, Seto Y, Fukayama M
    • Journal Title

      Mod Pathol

      Volume: 30 Issue: 3 Pages: 427-439

    • DOI

      10.1038/modpathol.2016.202

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Tumor Content Chart-Assisted HER2/CEP17 Digital PCR Analysis of Gastric Cancer Biopsy Specimens.2016

    • Author(s)
      Matsusaka K, Ishikawa S, Nakayama A, Ushiku T, Nishimoto A, Urabe M, Kaneko N, Kunita A, Kaneda A, Aburatani H, Fujishiro M, Seto Y, Fukayama M.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 4 Pages: e0154430-e0154430

    • DOI

      10.1371/journal.pone.0154430

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pathologic response of HER2-positive gastric cancer to Trastuzumab-based chemotherapy.2016

    • Author(s)
      Urabe M, Ushiku T, Seto Y, Fukayama M
    • Journal Title

      Am J Surg Pathol

      Volume: 40 Issue: 10 Pages: 1326-1333

    • DOI

      10.1097/pas.0000000000000672

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive mutation profiling of mucinous gastric carcinoma.2016

    • Author(s)
      Rokutan H, Hosoda F, Hama N, Nakamura H, Totoki Y, Furukawa E, Arakawa E, Ohashi S, Urushidate T, Satoh H, Shimizu H, Igarashi K, Yachida S, Katai H, Taniguchi H, Fukayama M, Shibata T.
    • Journal Title

      J Pathol

      Volume: 240 Issue: 2 Pages: 137-148

    • DOI

      10.1002/path.4761

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low density of CD204-positive M2-type tumor-associated macrophages in Epstein-Barr virus-associated gastric cancer: a clinicopathologic study with digital image analysis2016

    • Author(s)
      T. Ichimura, H. Abe, T. Morikawa, H. Yamashita, S. Ishikawa, T. Ushiku, Y. Seto, M. Fukayama
    • Journal Title

      Hum Pathol

      Volume: 56 Pages: 74-80

    • DOI

      10.1016/j.humpath.2016.06.002

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coupling CDH17 and CLDN18 markers for comprehensive membrane-targeted detection of human gastric cancer.2016

    • Author(s)
      K. Matsusaka, T. Ushiku, M. Urabe, M. Fukuyo, H. Abe, S. Ishikawa, Y. Seto, H. Aburatani, T. Hamakubo, A. Kaneda, M. Fukayama
    • Journal Title

      Oncotarget

      Volume: 7 Issue: 39 Pages: 64168-64181

    • DOI

      10.18632/oncotarget.11638

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] In Epstein-Barr -associated gastric carcinoma a high density of CD66b-positive tumor-associated neutrophils is associated with intestinal-type histology and low frequency of lymph node metastasis.2016

    • Author(s)
      Abe H, Morikawa T, Saito R, Yamashita H, Seto Y, Fukayama M.
    • Journal Title

      Virchows Arch

      Volume: in press

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] RHOA mutation in diffuse-type gastric cancer: a comparative clinicopathology analysis of 87 cases.2016

    • Author(s)
      Ushiku T, Ishikawa S, Kakiuchi M, Tanaka A, Katoh H, Aburatani H, Lauwers GY,Fukayama M.
    • Journal Title

      Gastric Cancer

      Volume: in oress

    • NAID

      40020835356

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Epstein-Barr virus-associated gastric carcinoma: Use of host cell machineries and somatic gene mutations.2015

    • Author(s)
      Abe H, Kaneda A, Fukayama M.
    • Journal Title

      Pathobiology

      Volume: 82 Issue: 5 Pages: 212-232

    • DOI

      10.1159/000434683

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Update on Epstein-Barr virus and gastric cancer (Review).2015

    • Author(s)
      Shinozaki-Ushiku A, Kunita A, Fukayama M.
    • Journal Title

      Int J Oncol

      Volume: 46 Issue: 4 Pages: 1421-1434

    • DOI

      10.3892/ijo.2015.2856

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Profiling of virus-encoded mcroRNAs in Epstein-Barr virus-associated gastric carcinoma and their roles in gastric carcinogenesis.2015

    • Author(s)
      Shinozaki-Ushiku A, Kunita A, Isogai M, Hibiya T, Ushiku T, Takada K, and Fukayama M
    • Journal Title

      J Virol

      Volume: 89 Issue: 10 Pages: 5581-5591

    • DOI

      10.1128/jvi.03639-14

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 胃癌とEBウイルス2015

    • Author(s)
      阿部 浩幸, 深山 正久
    • Journal Title

      臨床消化器内科

      Volume: 30 Pages: 41-44

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma.2014

    • Author(s)
      Kakiuchi M, Nishizawa T, Ueda H, Gotoh K, Tanaka A, Hayashi A, Yamamoto S, Tatsuno K, Katoh H, Watanabe Y, Ichimura T, Ushiku T, Funahashi S, Tateishi K, Wada I, Shimizu N, Nomura S, Koike K, Seto Y, Fukayama M, Aburatani H, Ishikawa S
    • Journal Title

      Nat Genet.

      Volume: 46(6) Issue: 6 Pages: 583-7

    • DOI

      10.1038/ng.2984

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] バレット食道の表在腺癌におけるp53,ARID1A,EZH2の免疫組織学的発現の検討.2018

    • Author(s)
      阿部浩幸,深山正久,Vieth Michael
    • Organizer
      第107回日本病理学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 胃癌におけるSWI/SNF複合体異常は腫瘍内不均一性が高くEBV・MSI陽性群で高頻度に認められる.2018

    • Author(s)
      岩崎晶子,牛久哲男,山澤翔,阿部浩幸,牛久綾,深山正久
    • Organizer
      第107回日本病理学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 胃癌におけるTP53変異とは独立したゲノム・エピゲノム相互作用の同定.2018

    • Author(s)
      松坂恵介,眞野恭伸,福世真樹,浦辺雅之,喜多和子,根本哲弘,ラムヒトラ・バハテヤリ ,瀬戸泰之,深山正久,金田篤志
    • Organizer
      第107回日本病理学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 胃癌組織におけるEZH2の臨床病理学的意義およびARID1A,BAP1との関係について.2018

    • Author(s)
      大井手慶,阿部浩幸,山澤翔,牛久哲男,深山正久
    • Organizer
      第107回日本病理学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 胃癌環境におけるB細胞の成熟過程を塩基配列レベルで解析する.2018

    • Author(s)
      香田弘知,加藤洋人,渥美振一郎,河村大輔,阿部浩幸,牛久哲男,深山正久,石川俊平
    • Organizer
      第107回日本病理学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 胎児型形質胃癌のゲノム解析.2018

    • Author(s)
      田頭周,谷内田真一,六反啓文,垣内美和子,山本尚吾,辰野健二,山澤翔,深山正久,油谷浩幸
    • Organizer
      第107回日本病理学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Defined Life style and Germline Factors Predispose Asian Populations to Gastric Cancer.2018

    • Author(s)
      Suzuki A, Kakiuchi M, Tagashira A, Katoh H, Yamamoto S, Tatsuno K, Sakai E, Ohshima T, Rino Y, Nakajima A, Fukayama M, Ishikawa S, Aburatani H
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 高メチル化胃癌における野生型TP53に基づいたゲノム・エピゲノム変異の同定.2018

    • Author(s)
      松坂恵介,眞野恭伸,福世真樹,浦辺雅之,バハテヤリ・ラムヒトラ,池田英里子,喜多和子,阿部浩幸,根本哲宏,瀬戸泰之,深山正久,金田篤志
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 免疫組織学的に診断されたAFP産生胃癌の長期予後の検討.2018

    • Author(s)
      前澤幸男,利野靖,鈴木昭宏,青山徹,山田貴允,佐藤勉,大島貴,湯川寛夫,吉川貴己,牛久哲男,深山正久,石川俊平,油谷浩幸
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Carcinoma with primitive phenotype: an aggressive subgroup of intestinal-type gastric cancer.2017

    • Author(s)
      Ushiku T, Yamazawa S, Iwasaki A, Shinozaki-Ushiku A, Seto Y, Fukayama M
    • Organizer
      第89回日本胃癌学会総会
    • Place of Presentation
      広島国際会議場,広島市
    • Year and Date
      2017-03-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] Epstein-Barr associated gastric cancer.2017

    • Author(s)
      Fukayama M
    • Organizer
      第89回日本胃癌学会総会
    • Place of Presentation
      広島国際会議場,広島市
    • Year and Date
      2017-03-08
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 胃癌におけるCD47発現の臨床病理学的特徴及びEBV感染やTリンパ球浸潤との関連.2017

    • Author(s)
      阿部浩幸,西東瑠璃,山澤翔,牛久綾,山下裕玄,瀬戸泰之,深山正久
    • Organizer
      第106回日本病理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ミスマッチ修復欠損・EBV関連早期胃癌ではARID1Aの多巣性発現消失が高頻度に生じている.2017

    • Author(s)
      岩崎晶子, 牛久哲男, 山澤翔, 阿部浩幸, 牛久綾, 深山正久
    • Organizer
      第106回日本病理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] NLRP3の細胞遊走促進とびまん型胃癌での予後への影響.2017

    • Author(s)
      西東瑠璃,阿部浩幸,国田朱子,山下裕玄,瀬戸泰之,深山正久
    • Organizer
      第106回日本病理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 胎児型形質を有する胃癌の臨床病理学的検討2017

    • Author(s)
      山澤翔, 牛久哲男, 岩崎晶子, 牛久綾, 瀬戸泰之, 深山正久
    • Organizer
      第106回日本病理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒト胃がんにおける腫瘍浸潤性T細胞の免疫遺伝学的な特徴の分析.2017

    • Author(s)
      加藤 洋人, 河村 大輔, 小西 寛城, 山本 麻未, 深山 正久, 石川 俊平
    • Organizer
      第106回日本病理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高DNAメチル化胃癌における特異的ゲノム・エピゲノム異常の同定.2017

    • Author(s)
      松坂 恵介(千葉大学 院・分子腫瘍学), 眞野 恭伸, 福世 真樹, 浦辺 雅之, 阿部 浩幸, バハテヤリ・ラムヒトラ , 油谷 浩幸, 瀬戸 泰之, 深山 正久, 金田 篤志
    • Organizer
      第106回日本病理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] EBV関連胃癌における樹状細胞の免疫組織化学的検討.2017

    • Author(s)
      日向宗利,阿部浩幸,山下裕玄,瀬戸泰之,深山正久
    • Organizer
      第106回日本病理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] びまん型胃癌におけるRHOA変異とCLDN18転座の臨床病理学的意義2016

    • Author(s)
      田中淳,牛久哲男,国田朱子,石川俊平,深山正久
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜,横浜市
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] EBV関連胃癌におけるEZH2高発現とその意義2016

    • Author(s)
      阿部浩幸,国田朱子,牛久綾,深山正久
    • Organizer
      第105回日本病理学会総会
    • Place of Presentation
      仙台国際会議場,仙台市
    • Year and Date
      2016-05-12
    • Related Report
      2016 Annual Research Report
  • [Presentation] EBV関連胃癌におけるPD-L1の高率な発現と予後への影響2016

    • Author(s)
      西東瑠璃,阿部浩幸,国田朱子,深山正久
    • Organizer
      第105回日本病理学会総会
    • Place of Presentation
      仙台国際会議場,仙台市
    • Year and Date
      2016-05-12
    • Related Report
      2016 Annual Research Report
  • [Presentation] びまん型胃癌におけるRHOA変異とCLDN18-ARHGAP転座の意義2016

    • Author(s)
      田中淳,牛久哲男,国田朱子,石川俊平,深山正久
    • Organizer
      第105回日本病理学会総会
    • Place of Presentation
      仙台国際会議場,仙台市
    • Year and Date
      2016-05-12
    • Related Report
      2016 Annual Research Report
  • [Presentation] 胃癌におけるClaudin6の発現とその臨床病理学的意義についての検討2016

    • Author(s)
      山澤翔, 牛久綾, 牛久哲男, 深山正久
    • Organizer
      第105回日本病理学会総会
    • Place of Presentation
      仙台国際会議場,仙台市
    • Year and Date
      2016-05-12
    • Related Report
      2016 Annual Research Report
  • [Presentation] CD66b-Positive Tumor-Associated Neutrophils in Epstein-Barr Virus Associated Gastric Carcinoma: A Comparative Study with CD8-Positive Cytotoxic T-Lymphocytes.2016

    • Author(s)
      Abe H, Morikawa T, Saito R, Yamashita H, Seto Y, Fukayama M
    • Organizer
      The 105th Annual Meeting of the United States and Canadian Academy of Pathology
    • Place of Presentation
      Washington State Convetion Center, Seattle, WA, USA
    • Year and Date
      2016-03-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] びまん型胃癌におけるRHOA変異の意義2015

    • Author(s)
      田中淳,牛久哲男,石川俊平,深山正久
    • Organizer
      第104回日本病理学会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-04-30 – 2015-05-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] びまん性胃癌におけるRHOA変異2015

    • Author(s)
      石川俊平,垣内美和子, 加藤洋人, 鈴木良平, 田中淳, 林玲匡, 牛久哲夫, 深山正久, 油谷浩幸
    • Organizer
      第104回日本病理学会総会
    • Place of Presentation
      名古屋国際会議場,名古屋市
    • Year and Date
      2015-04-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] EBV関連胃癌2015

    • Author(s)
      牛久綾,深山正久
    • Organizer
      第104回日本病理学会総会
    • Place of Presentation
      名古屋国際会議場,名古屋市
    • Year and Date
      2015-04-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Book] EBウイルス関連胃癌の病理(EBウイルス関連胃癌)2016

    • Author(s)
      阿部浩幸,深山正久
    • Total Pages
      92
    • Publisher
      診断と治療社
    • Related Report
      2016 Annual Research Report
  • [Book] EBウイルス 改訂第3版(分担)2015

    • Author(s)
      深山正久
    • Total Pages
      232
    • Publisher
      診断と治療
    • Related Report
      2015 Annual Research Report
  • [Book] 腫瘍病理鑑別診断アトラス「胃癌」第二版(分担)2015

    • Author(s)
      牛久綾,深山正久
    • Total Pages
      318
    • Publisher
      文光堂
    • Related Report
      2015 Annual Research Report
  • [Remarks] 東京大学人体病理学・病理診断学分野

    • URL

      http://pathol.umin.ac.jp/index.shtml

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report 2016 Annual Research Report
  • [Remarks] 東京大学人体病理学・病理診断学分野

    • URL

      http://pathol.umin.ac.jp/fukayama.shtml

    • Related Report
      2015 Annual Research Report
  • [Remarks] 東京大学医学部人体病理学

    • URL

      http://pathol.umin.ac.jp/staff.shtml

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-11-20   Modified: 2020-03-30  

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