Infection memory: study on antiviral functions of endogenous viruses
| Project/Area Number |
26253027
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Kyoto University |
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Principal Investigator |
Tomonaga Keizo 京都大学, ウイルス・再生医科学研究所, 教授 (10301920)
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| Co-Investigator(Renkei-kenkyūsha) |
HONDA Tomoyuki 大阪大学, 大学院医学研究科, 准教授 (80402676)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥40,560,000 (Direct Cost: ¥31,200,000、Indirect Cost: ¥9,360,000)
Fiscal Year 2016: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2015: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2014: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
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| Keywords | 内在性ウイルス / ボルナウイルス / ウイルス抵抗性 / 外適応 / 進化 / 内在性RNAウイルス / 共進化 / 感染防御 / ウイルス / ゲノム |
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| Outline of Final Research Achievements |
It is suggested that our life-form has a mechanism to memorize virus infections as endogenous element in the genomes and uses them as novel genes on evolution. This study was carried out to understand the functions, especially antiviral activity, of endogenous bornavirus-like elements (EBLs) in mammalian genomes, which we found in a previous report. In this study, we demonstrated the expression regulation of EBLs in human genomes, as well as function of a human EBL to regulate neighboring gene expression. Furthermore, we showed that EBLs from mouse and Thirteen-liked ground squirrel genomes express piwi-interacting RNA and protein, respectively, and could act as antiviral factors against bornavirus infection in cultured cells. Moreover, we revealed the possibility that EBLs endogenized in the genome of the Eptesicus genus bat genome encode a functional RNA dependent RNA polymerase derived from ancient bornavirus infection.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] An RNA-dependent RNA polymerase gene in bat genomes derived from an ancient negative-strand RNA virus.2016
Author(s)
Horie M, Kobayashi Y, Honda T, Fujino K, Akasaka T, Kohl C, Wibbelt G, Muhldorfer K, Kurth A, Muller MA, Corman VM, Gillich N, Suzuki Y, Schwemmle M, Tomonaga K.
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Journal Title
Sci Rep.
Volume: 6
Issue: 1
Pages: 25873-25873
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] piRNAs derived from ancient viral processed pseudogenes as transgenerational sequence-specific immune memory in mammals.2015
Author(s)
Parrish NF, Fujino K, Shiromoto Y, Iwasaki YW, Ha H, Xing J, Makino A, Kuramochi-Miyagawa S, Nakano T, Siomi H, Honda T, Tomonaga K.
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Journal Title
RNA.
Volume: 21
Issue: 10
Pages: 1691-703
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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