• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Genome wide association study to explore drinking behavior in Japanese

Research Project

Project/Area Number 26253041
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Epidemiology and preventive medicine
Research InstitutionAichi Cancer Center Research Institute (2015-2016)
Kyushu University (2014)

Principal Investigator

Matsuo Keitaro  愛知県がんセンター(研究所), 遺伝子医療研究部, 部長 (80393122)

Co-Investigator(Kenkyū-buntansha) 大中 佳三  九州大学, 医学(系)研究科(研究院), 講師 (30325518)
山本 健  久留米大学, 医学部, 教授 (60274528)
細野 覚代  愛知県がんセンター(研究所), 疫学・予防部, 主任研究員 (80402600)
高柳 涼一  九州大学, 医学(系)研究科(研究院), 教授 (30154917)
Co-Investigator(Renkei-kenkyūsha) ITO Hidemi  愛知県がんセンター(研究所), 遺伝子医療研究部, 室長 (90393123)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥42,120,000 (Direct Cost: ¥32,400,000、Indirect Cost: ¥9,720,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2014: ¥32,240,000 (Direct Cost: ¥24,800,000、Indirect Cost: ¥7,440,000)
KeywordsALDH2 / GWAS / 飲酒 / polymorphism / alcohol drinking / 遺伝子多型 / 飲酒習慣 / 全ゲノム関連解析 / 遺伝子環境要因交互作用 / 飲酒行動 / 日本人
Outline of Final Research Achievements

We tried to identify new genetic loci for alcohol drinking behaviour among Japanese population. We first tried to examine a cross-sectional study at Aichi Cancer Center and identified previously reported ALDH2 rs671 as a single significant locus. We extended analysis using other epidemiological study with genome-scan data, but failed to identify new locus. Therefore, we changed research focus to identify new diseases which may modified or influence by ALDH2 rs671 polymorphism. We firstly discovered that bladder cancer, formerly regarded as non-alcohol related cancer as acetaldehyde related cancer when we consider ALDH2 genotype. This association was replicated in an independent study. Moreover, association between smoking initiation/quitting and ALDH2 genotype was discovered. For possible application in cancer prevention, we developed risk prediction model and estimated cumulative risk.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (31 results)

All 2017 2016 2015 Other

All Int'l Joint Research (9 results) Journal Article (13 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 13 results,  Open Access: 6 results,  Acknowledgement Compliant: 7 results) Presentation (9 results) (of which Int'l Joint Research: 4 results,  Invited: 3 results)

  • [Int'l Joint Research] National Cancer Insitute(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Mario Negri Institute(Italy)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Cambridge University(英国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Centre for Cancer Genetic Epidemiology/Department of Oncology/University of Cambridge(United Kingdom)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Ctr for Epidemiol and Biostatistics/School of Population and Global Health/The University of Melbourne(Australia)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Breast Cancer Research Unit/University Malaya Cancer Res Inst/University Malaya Medical Centre(マレーシア)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Department of Epidemiology/Shanghai Cancer Institute(China)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] College of Public Health,/China Medical University(Taiwan)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Heterogeneous impact of alcohol consumption according to treatment method on survival in head and neck cancer: A prospective study.2017

    • Author(s)
      Sawabe M, Ito H, Oze I, Hosono S, Kawakita D, Tanaka H, Hasegawa Y, Murakami S, Matsuo K.
    • Journal Title

      Cancer Sci

      Volume: 108 Issue: 1 Pages: 91-100

    • DOI

      10.1111/cas.13115

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Aldehyde Dehydrogenase 2 Polymorphism Is a Predictor of Smoking Cessation.2017

    • Author(s)
      Masaoka H, Gallus S, Ito H, Watanabe M, Yokomizo A, Eto M, Matsuo K.
    • Journal Title

      Nicotine Tob Res

      Volume: 未定

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Combination of ALDH2 and ADH1B polymorphisms is associated with smoking initiation: A large-scale cross-sectional study in a Japanese population.2017

    • Author(s)
      Masaoka H, Ito H, Gallus S, Watanabe M, Yokomizo A, Eto M, Matsuo K.
    • Journal Title

      Drug Alcohol Depend

      Volume: 173 Pages: 85-91

    • DOI

      10.1016/j.drugalcdep.2016.12.015

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Alcohol and lung cancer risk among never smokers: A pooled analysis from the international lung cancer consortium and the SYNERGY study.2017

    • Author(s)
      Fehringer G, Brenner DR, Zhang ZF, Lee YA, Matsuo K, et al.
    • Journal Title

      Int J Cancer

      Volume: 140 Issue: 9 Pages: 1976-1984

    • DOI

      10.1002/ijc.30618

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations.2017

    • Author(s)
      Seow WJ, Matsuo K, Hsiung CA, Shiraishi K, et al
    • Journal Title

      Hum Mol Genet.

      Volume: 26(2) Pages: 454-465

    • DOI

      10.1093/hmg/ddw414

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) polymorphisms exacerbate bladder cancer risk associated with alcohol drinking: Gene-environment interaction.2016

    • Author(s)
      Masaoka H, Ito H, Soga N, Hosono S, Oze I, Watanabe M, Tanaka H, Yokomizo A, Hayashi N, Eto M, Matsuo K.
    • Journal Title

      Carcinogenesis

      Volume: in press Issue: 6 Pages: 583-585

    • DOI

      10.1093/carcin/bgw033

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The phenotype and clinical course of Japanese Fanconi Anaemia infants is influenced by patient, but not maternal ALDH2 genotype.2016

    • Author(s)
      Yabe M, Yabe H, Morimoto T, Fukumura A, Ohtsubo K, Koike T, Yoshida K, Ogawa S, Ito E, Okuno Y, Muramatsu H, Kojima S, Matsuo K, Hira A, Takata M.
    • Journal Title

      Br J Haematol.

      Volume: 175 Issue: 3 Pages: 457-461

    • DOI

      10.1111/bjh.14243

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170.2016

    • Author(s)
      Dunning AM, Michailidou K, Kuchenbaecker KB, (54名略),Matsuo K,(187名略)Easton DF, Edwards SL.
    • Journal Title

      Nat Genet

      Volume: 48 Issue: 4 Pages: 374-386

    • DOI

      10.1038/ng.3521

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Development of a prediction model and estimation of cumulative risk for upper aerodigestive tract cancer on the basis of the aldehyde dehydrogenase 2 genotype and alcohol consumption in a Japanese population.2016

    • Author(s)
      Koyanagi YN, Ito H, Oze I, Hosono S, Tanaka H, Abe T, Shimizu Y, Hasegawa Y, Matsuo K
    • Journal Title

      Eur J Cancer Prev.

      Volume: 印刷中 Issue: 1 Pages: 38-47

    • DOI

      10.1097/cej.0000000000000222

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular epidemiology, and possible real-world applications in breast cancer.2015

    • Author(s)
      Ito H, Matsuo K.
    • Journal Title

      Breast Cancer

      Volume: in press

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A rare truncating BRCA2 variant and genetic susceptibility to upper aerodigestive tract cancer.2015

    • Author(s)
      Delahaye-Sourdeix M, Anantharaman D, Timofeeva MN, (40名省略), Matsuo K, Franceschi S, Byrnes G, Brennan P, McKay JD.
    • Journal Title

      J Natl Cancer Inst

      Volume: 107 Issue: 5

    • DOI

      10.1093/jnci/djv037

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The 12p13.33/RAD52 Locus and Genetic Susceptibility to Squamous Cell Cancers of Upper Aerodigestive Tract.2015

    • Author(s)
      Delahaye-Sourdeix M, Oliver J, Timofeeva MN, (44名省略), Matsuo K, Franceschi S, Byrnes G, Brennan P, McKay JD.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 3 Pages: e0117639-e0117639

    • DOI

      10.1371/journal.pone.0117639

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.2015

    • Author(s)
      Michailidou K, Beesley J, Lindstrom S, (80名省略), Matsuo K, (159名省略), Easton DF.
    • Journal Title

      Nat Genet

      Volume: 47 Issue: 4 Pages: 373-380

    • DOI

      10.1038/ng.3242

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] Development of a prediction model and estimation of cumulative risk for upper aerodigestive tract cancer based on aldehyde dehydrogenase 2 (ALDH2) genotype and alcohol consumption in a Japanese population2016

    • Author(s)
      Koyanagi Y, Ito H, Oze I, Hosono S, Tanaka H, Abe T, Shimizu Y, Hasegawa Y, Matsuo K.
    • Organizer
      European Association of Cancer Research Biennial Meeting
    • Place of Presentation
      Manchester
    • Year and Date
      2016-07-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ALDH2 and ADH1B polymorphisms exacerbate bladder cancer risk associated with alcohol drinking.2016

    • Author(s)
      Masaoka H, Ito H, Soga N, Yokomizo A, Eto M, Matsuo K.
    • Organizer
      European Association of Cancer Research Biennial Meeting
    • Place of Presentation
      Manchester
    • Year and Date
      2016-07-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A genetic polymorphism of ALDH2 and breast cancer risk: an analysis of 6,624 cases and 5,750 controls from the Breast Cancer Association Consortium2016

    • Author(s)
      Ugai T, Milne RL, Ito H, Matsuo K.
    • Organizer
      American Association for Cancer Research
    • Place of Presentation
      New Oreleans
    • Year and Date
      2016-04-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ALDH2 Glu504Lys polymorphism and breast cancer risk: Analysis of 6,624 cases and 5,750 controls from the Breast Cancer Association Consortium2016

    • Author(s)
      Ugai T, Milne RL, Ito H, Matsuo K.
    • Organizer
      American Association of Cancer Research Annual Meeting 2016
    • Place of Presentation
      New Orleans
    • Year and Date
      2016-04-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アセトアルデヒド脱水素酵素2(ALDH2)の遺伝子多型の女性乳癌に対する影響2016

    • Author(s)
      鵜飼知嵩、伊藤秀美、松尾恵太郎
    • Organizer
      第26回日本疫学会学術総会
    • Place of Presentation
      米子コンベンションセンター(米子市)
    • Year and Date
      2016-01-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] リスク評価に基づくがん予防2015

    • Author(s)
      松尾恵太郎
    • Organizer
      がん予防学術大会2015さいたま
    • Place of Presentation
      ラフレさいたま
    • Year and Date
      2015-06-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 遺伝情報を含めたがん予防研究2015

    • Author(s)
      松尾恵太郎
    • Organizer
      第85回日本衛生学会学術総会
    • Place of Presentation
      和歌山県民文化会館
    • Year and Date
      2015-03-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] A risk prediction model for upper aerodigestive tract cancer among Japanese with lifestyle and genetic information: Possible use in prevention.2015

    • Author(s)
      Matsuo K
    • Organizer
      Japan-US Workshop for Innovative Cancer Biomarker Development
    • Place of Presentation
      Tokyo Conference Center Ariake
    • Year and Date
      2015-03-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Establishment of a personialized preventive strategy of upper aerodigestive tract cancer using risk prediction model.2015

    • Author(s)
      Koyanagi Y, Ito H, Oze I, Hosono S, Tanaka H, Matsuo K
    • Organizer
      第25回日本疫学会学術総会
    • Place of Presentation
      Nagoya
    • Year and Date
      2015-01-22
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2022-03-01  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi