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Study of the liver as an endocrine organ

Research Project

Project/Area Number 26253046
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionKanazawa University

Principal Investigator

KANEKO Shuichi  金沢大学, 医学系, 教授 (60185923)

Co-Investigator(Kenkyū-buntansha) 本多 政夫  金沢大学, 保健学系, 教授 (00272980)
井上 啓  金沢大学, 新学術創成研究機構, 教授 (50397832)
篁 俊成  金沢大学, 医学系, 教授 (00324111)
水腰 英四郎  金沢大学, 医学系, 准教授 (90345611)
御簾 博文  金沢大学, 医学系, 准教授 (80447680)
竹下 有美枝  金沢大学, 附属病院, 助教 (40507042)
太田 嗣人  金沢大学, 先進予防医学研究センター, 准教授 (60397213)
Project Period (FY) 2014-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥41,210,000 (Direct Cost: ¥31,700,000、Indirect Cost: ¥9,510,000)
Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2017: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2016: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2014: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Keywordsゲノム / 発現制御 / 肝臓 / 栄養 / 生活習慣病
Outline of Final Research Achievements

Hyper-nutrition causes a variety of systematic diseases. Especially, function of the liver is impaired by the nutrition, and successively non alcoholic fatty liver (NAFLD) and non alcoholic steatohepatitis (NASH) are caused. In this study, we systematically analyzed gene expression profiles of the liver, and studied the effect of NAFLF and NASH on systemic diseases and the pathology. We have reported two proteins, Selenoprotein P and Lect 2, as hepatokines. Selenoprotein P induces insulin resistance of the liver and the muscle, and exercise resistance of the muscle. Also, we showed the measurement of Selenoprotein P predicts occurrence of glucose intolerance in future.

Academic Significance and Societal Importance of the Research Achievements

過剰な栄養は糖尿病、脂質異常症、高血圧といった多くの疾患と関連し、肝臓には脂肪肝を引き起こす。本研究では脂肪肝そのものが、ヘパトカインを介して糖尿病など他の全身疾患に影響を与えることを明らかにした。このことは肝臓を対象とした新たな治療薬や診断法を開発することが現代の多くの疾患を克服するうえで重要なことを示しており、学術的にも社会的にも意義が大きい。

Report

(6 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report

Research Products

(67 results)

All 2019 2018 2017 2016 2015 2014 Other

All Journal Article (49 results) (of which Int'l Joint Research: 23 results,  Peer Reviewed: 49 results,  Open Access: 49 results,  Acknowledgement Compliant: 20 results) Remarks (3 results) Patent(Industrial Property Rights) (15 results) (of which Overseas: 2 results)

  • [Journal Article] Serum aldo-keto reductase family 1 member B10 predicts advanced liver fibrosis and fatal complications of nonalcoholic steatohepatitis.2019

    • Author(s)
      M Kanno, K Kawaguchi, M Honda, R Horii, H Takatori, T Shimakami, K Kitamura, K Arai, T Yamashita, Y Sakai, T Yamashita, E Mizukoshi, S Kaneko.
    • Journal Title

      J Gastroenterol.

      Volume: - Pages: 549-557

    • DOI

      10.1007/s00535-019-01551-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Circulating Concentrations of Insulin Resistance-Associated Hepatokines, Selenoprotein P and Leukocyte Cell-Derived Chemotaxin 2, during an Oral Glucose Tolerance Test in Humans2019

    • Author(s)
      Mohri K, Misu H, Takayama H, Ishii KA, Kikuchi A, Lan F, Enyama Y, Takeshita Y, Saito Y, Kaneko S,Takamura T.
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 42 Issue: 3 Pages: 373-378

    • DOI

      10.1248/bpb.b18-00549

    • NAID

      130007607371

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ribavirin-induced down-regulation of CCAAT/enhancer-binding protein α leads to suppression of lipogenesis2019

    • Author(s)
      Satoh Shinya、Onomura Daichi、Ueda Youki、Dansako Hiromichi、Honda Masao、Kaneko Shuichi、Kato Nobuyuki
    • Journal Title

      Biochem J

      Volume: 476 Pages: 137-149

    • DOI

      10.1042/bcj20180680

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characteristics of Immune Response to Tumor‐Associated Antigens and Immune Cell Profile in Patients With Hepatocellular Carcinoma.2019

    • Author(s)
      Y Inada, E Mizukoshi, T Seike, T Tamai, N Iida, M Kitahara, T Yamashita, K Arai, T Terashima, K Fushimi, T Yamashita, M Honda, S Kaneko.
    • Journal Title

      Hepatology

      Volume: 69 Pages: 653-665

    • DOI

      10.1002/hep.30212

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] p62-mediated autophagy affects nutrition-dependent insulin receptor substrate 1 dynamics in 3T3-L1 preadipocytes2019

    • Author(s)
      Igawa Hirobumi、Kikuchi Akihiro、Misu Hirofumi、Ishii Kiyo-aki、Kaneko Shuichi、Takamura Toshinari
    • Journal Title

      J Diabetes Investig

      Volume: 10 Pages: 32-42

    • DOI

      10.1111/jdi.12866

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of metformin and alogliptin on body composition in people with type 2 diabetes.2019

    • Author(s)
      Takeshita Y, Kita Y, Kato KI, Kanamori T, Misu H, Kaneko, Takamura T.
    • Journal Title

      J Diabetes Investig.

      Volume: Aug Pages: 29-29

    • DOI

      10.1111/jdi.12920

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum selenoprotein P, but not selenium, predicts future hyperglycemia in a general Japanese population.2018

    • Author(s)
      Oo SM, Misu H, Saito Y, Tanaka M, Kato S, Kita Y, Takayama H, Takeshita Y, Kanamori T, Nagano T, Nakagen M, Urabe T, Matsuyama N, Kaneko S, Takamura T.
    • Journal Title

      Sci Rep

      Volume: 8 Pages: 16727-16727

    • DOI

      10.1038/s41598-018-35067-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Immune response to human telomerase reverse transcriptase-derived helper T cell epitopes in hepatocellular carcinoma patients2018

    • Author(s)
      Kumagai Masashi、Mizukoshi Eishiro、Tamai Toshikatsu、Kitahara Masaaki、Yamashita Tatsuya、Arai Kuniaki、Terashima Takeshi、Iida Noriho、Fushimi Kazumi、Kaneko Shuichi
    • Journal Title

      Liver Int

      Volume: 印刷中 Pages: 1635-1645

    • DOI

      10.1111/liv.13713

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of Human Selenoprotein P Determinants in Serum between Our Original Methods and Commercially Available Kits2018

    • Author(s)
      Saito Yoshiro、Misu Hirofumi、Takayama Hiroaki、Takashima Shin-ichiro、Usui Soichiro、Takamura Masayuki、Kaneko Shuichi、Takamura Toshinari、Noguchi Noriko
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 41 Issue: 5 Pages: 828-832

    • DOI

      10.1248/bpb.b18-00046

    • NAID

      130006730702

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prevention of hepatocellular carcinoma by targeting MYCN-positive liver cancer stem cells with acyclic retinoid2018

    • Author(s)
      Qin XY, Suzuki H, Honda M, Okada H, Kaneko S, Inoue I, Ebisui E, Hashimoto K, Carninci P, Kanki K, Tatsukawa H, Ishibashi N, Masaki T, Matsuura T, Kagechika H, Toriguchi K, Hatano E, Shirakami Y, Shiota G, Shimizu M, Moriwaki H, Kojima S
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 115 Pages: 4969-4974

    • DOI

      10.1073/pnas.1802279115

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A porcine placental extract prevents steatohepatitis by suppressing activation of macrophages and stellate cells in mice.2018

    • Author(s)
      L Xu, N Nagata, M Nagashimada, F Zhuge, Y Ni, G Chen, J Kamei, H Ishikawa, Y Komatsu, S Kaneko, T Ota.
    • Journal Title

      Oncotarget

      Volume: 9 Pages: 15047-15060

    • DOI

      10.18632/oncotarget.24587

    • NAID

      120006452383

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ursodeoxycholic acid potentiates dipeptidyl peptidase-4 inhibitor sitagliptin by enhancing glucagon-like peptide-1 secretion in patients with type 2 diabetes and chronic liver disease: a pilot randomized controlled and add-on study2018

    • Author(s)
      K. R. Shima, T. Ota, K. I. Kato, Y. Takeshita, H. Misu, S. Kaneko and T. Takamura
    • Journal Title

      BMJ Open Diabetes Research & Care

      Volume: 6

    • DOI

      10.1136/bmjdrc-2017-000469

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Light alcohol consumption has the potential to suppress hepatocellular injury and liver fibrosis in non-alcoholic fatty liver disease.2018

    • Author(s)
      K Yamada, E Mizukoshi, T Seike, R Horii, M Kitahara, H Sunagozaka, K Arai, T Yamashita, M Honda, S Kaneko.
    • Journal Title

      PLOS ONE

      Volume: 13

    • DOI

      10.1371/journal.pone.0191026

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein2018

    • Author(s)
      Watanabe Hitoshi、Inaba Yuka、Kimura Kumi、Matsumoto Michihiro、Kaneko Shuichi、Kasuga Masato、Inoue Hiroshi
    • Journal Title

      Nature Communications

      Volume: 9 Pages: 30-30

    • DOI

      10.1038/s41467-017-02537-6

    • NAID

      40021854359

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical and pathological significance of autoantibodies to erythropoietin receptor in type 2 diabetic patients with chronic kidney disease2018

    • Author(s)
      Hara A, Furuichi K, Koshino A, Yasuda H, Tran T, Iwata Y, Sakai N, Shimizu M, Kaneko S, Nakamura H, Wada T.
    • Journal Title

      Kidney International Reports

      Volume: 3 Pages: 133-141

    • DOI

      10.1016/j.ekir.2017.08.017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gene expression profiling of hepatocarcinogenesis in a mouse model of chronic hepatitis B2017

    • Author(s)
      Nosaka Takuto、Naito Tatsushi、Hiramatsu Katsushi、Ohtani Masahiro、Nemoto Tomoyuki、Marusawa Hiroyuki、Ma Ning、Hiraku Yusuke、Kawanishi Shosuke、Yamashita Taro、Kaneko Shuichi、Nakamoto Yasunari
    • Journal Title

      PLOS ONE

      Volume: 12

    • DOI

      10.1371/journal.pone.0185442

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Corrigendum to 'Weight-adjusted lean body mass and calf circumference are protective against obesity-associated insulin resistance and metabolic abnormalities'.2017

    • Author(s)
      T Takamura, Y Kita, M Nakagen, M Sakurai, Y Isobe, Y Takeshita, K Kawai, T Urabe, S Kaneko.
    • Journal Title

      Heliyon

      Volume: 3

    • DOI

      10.1016/j.heliyon.2017.e00363

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Eicosapentaenoic acid down-regulates expression of the selenoprotein P gene by inhibiting SREBP-1c protein independently of the AMP-activated protein kinase pathway in H4IIEC3 hepatocytes.2017

    • Author(s)
      Tajima-Shirasaki N, Ishii KA, Takayama H, Shirasaki T, Iwama H, Chikamoto K, Saito Y, Iwasaki Y, Teraguchi A, Lan F, Kikuchi A, Takeshita Y, Murao K, Matsugo S, Kaneko S, Misu H, Takamura T.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 292 Pages: 10791-10800

    • DOI

      10.1074/jbc.m116.747006

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hepatic Transcriptome Profiles of Mice with Diet-Induced Nonalcoholic Steatohepatitis Treated with Astaxanthin and Vitamin E.2017

    • Author(s)
      M Kobori, Y Takahashi, M Sakurai, Y Ni, G Chen, M Nagashimada, S Kaneko, T Ota.
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 18 Pages: 1-14

    • DOI

      10.3390/ijms18030593

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Branched-chain amino acids prevent hepatic fibrosis and development of hepatocellular carcinoma in a non-alcoholic steatohepatitis mouse model.2017

    • Author(s)
      K Takegoshi, M Honda, H Okada, R Takabatake, N Matsuzawa-Nagata, JS Campbell, M Nishikawa, T Shimakami, T Shirasaki, Y Sakai, T Yamashita, T Takamura, T Tanaka, S Kaneko.
    • Journal Title

      Oncotarget.

      Volume: 印刷中 Pages: 18191-18205

    • DOI

      10.18632/oncotarget.15304

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Glucoraphanin ameliorates obesity and insulin resistance through adipose tissue browning and reduction of metabolic endotoxemia in mice.2017

    • Author(s)
      Nagata N, Xu L, Kohno S, Ushida Y, Aoki Y, Umeda R, Fuke N, Zhuge F, Ni Y, Nagashimada M, Takahashi C, Suganuma H, Kaneko S and Ota T.
    • Journal Title

      Diabetes

      Volume: 印刷中 Pages: 1222-1236

    • DOI

      10.2337/db16-0662

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Association Between High-Avidity T-Cell Receptors, Induced by α-Fetoprotein-Derived Peptides, and Anti-Tumor Effects in Patients With Hepatocellular Carcinoma2017

    • Author(s)
      Nakagawa H, Mizukoshi E, Kobayashi E, Tamai T, Hamana H, Ozawa T, Kishi H, Kitahara M, Yamashita T, Arai K, Terashima T, Iida N, Fushimi K, Muraguchi A, Kaneko S
    • Journal Title

      Gastroenterology.

      Volume: 152 Pages: 1395-1406

    • DOI

      10.1053/j.gastro.2017.02.001

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle.2017

    • Author(s)
      H Misu, H Takayama, Y Saito, Y Mita, A Kikuchi, K Ishii, K Chikamoto, T Kanamori, N Tajima, F Lan, Y Takeshita, M Honda, M Tanaka, S Kato, N Matsuyama, Y Yoshioka, Iwayama K, Tokuyama K, Akazawa N, Maeda S, Takekoshi K, Matsugo S, Noguchi N, S Kaneko, T Takamura.
    • Journal Title

      Nat Med

      Volume: 23 Pages: 508-516

    • DOI

      10.1038/nm.4295

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The evolving concept of liver cancer stem cells.2017

    • Author(s)
      K Nio, T Yamashita, S Kaneko.
    • Journal Title

      Mol Cancer.

      Volume: 16 Pages: 1-12

    • DOI

      10.1186/s12943-016-0572-9

    • NAID

      120006027796

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dietary Mung Bean Protein Reduces Hepatic Steatosis, Fibrosis, and Inflammation in Male Mice with Diet-Induced, Nonalcoholic Fatty Liver Disease.2017

    • Author(s)
      Watanabe H, Inaba Y, Kimura K, Asahara SI, Kido Y, Matsumoto M, Motoyama T, Tachibana N, Kaneko S, Kohno M, Inoue H*.
    • Journal Title

      The Journal of Nutrition

      Volume: 147 Pages: 52-60

    • DOI

      10.3945/jn.116.231662

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] DPP-4 inhibition by linagliptin attenuates obesity-related inflammation and insulin resistance by regulating M1/M2 macrophage polarization.2016

    • Author(s)
      F Zhuge, Y Ni, M Nagashimada, N Nagata, L Xu, N Mukaida, S Kaneko, T Ota.
    • Journal Title

      Diabetes

      Volume: 65 Pages: 2966-2679

    • DOI

      10.2337/db16-0317

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Rapid response of the steatosis-sensing hepatokine LECT2 during diet-induced weight cycling in mice.2016

    • Author(s)
      K Chikamoto, H Misu, H Takayama, A Kikuchi, KA Ishii, F Lan, N Takata, N Tajima-Shirasaki, Y Takeshita, H Tsugane, S Kaneko, S Matsugo, T Takamura.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 478 Pages: 1310-1316

    • DOI

      10.1016/j.bbrc.2016.08.117

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Localizatoin of xenobiotic transporter OCTN1/SLC22A4 in hepatic stellate cells and its protective role in liver fibrosis.2016

    • Author(s)
      Tang Y, Masuo Y, Sakai Y, Wakayama T, Sugiura T, Harada R, Futatsugi A, Komura T, Nakamichi N, Sekiguchi H, Sutoh K, Usumi K, Iseki S, Kaneko S, Kato Y.
    • Journal Title

      J. Pharm. Sci.

      Volume: 印刷中 Pages: 1779-1789

    • DOI

      10.1016/j.xphs.2016.02.023

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Gadd34 regulates liver regeneration in hepatic steatosis.2015

    • Author(s)
      Inaba Y, Furutani T, Kimura K, Watanabe H, Haga S, Kido Y, Yamamoto Y, Harada K, Kaneko S, Oyadomari S, Ozaki M, Kasuga M, Inoue H.
    • Journal Title

      Hepatology

      Volume: 61(4) Pages: 1343-1356

    • DOI

      10.1002/hep.27619

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Bending of a vertical cannula without alarm during insulin pump therapy as a cause of unexpected hyperglycemia: A Japanese issue?2015

    • Author(s)
      Kuroda K, Takeshita Y, Kaneko S, Takamura T
    • Journal Title

      J Diabetes Investig

      Volume: 6 Pages: 739-740

    • DOI

      10.1111/jdi.12357

    • NAID

      120005689372

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sitagliptin versus mitiglinide switched from mealtime dosing of a rapid-acting insulin analog in patients with type 2 diabetes: a randomized, parallel-group study.2015

    • Author(s)
      Y Takeshita, T Takamura, Y Kita, A Takazakura, K Kato, Y Isobe, S Kaneko.
    • Journal Title

      BMJ Open Diabetes Res Care

      Volume: 3

    • DOI

      10.1136/bmjdrc-2015-000122

    • NAID

      120005774893

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Renoprotective effects of atorvastatin compared with pravastatin on progression of early diabetic nephropathy2015

    • Author(s)
      Takazakura A, Sakurai M, Bando Y, Misu H, Takeshita Y, Kita Y, Shimizu A, Hayakawa T, Kato K, Kaneko S, Takamura T
    • Journal Title

      J Diabetes Investig

      Volume: 6 Pages: 346-353

    • DOI

      10.1111/jdi.12296

    • NAID

      120005819637

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vildagliptin vs liraglutide as a second-line therapy switched from sitagliptin-based regimens in patients with type 2 diabetes: A randomized, parallel-group study.2015

    • Author(s)
      Takeshita Y, Takamura T, Kita Y, Otoda T, Kato K, Wakakuri H, Yamada M, Misu H, Matsushima Y, Kaneko S
    • Journal Title

      J Diabetes Investig

      Volume: 6 Pages: 192-200

    • DOI

      10.1111/jdi.12269

    • NAID

      120005774894

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E2015

    • Author(s)
      Ni Y, Nagashimada M, Zhuge F, Zhan L, Nagata N, Tsutsui A, Nakanuma Y, Kaneko S, Ota T
    • Journal Title

      Scientific Reports

      Volume: 5 Pages: 17192-17192

    • DOI

      10.1038/srep17192

    • NAID

      120005682635

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Phase I trial of multidrug resistance-associated protein 3-derived peptide in patients with hepatocellular carcinoma.2015

    • Author(s)
      E Mizukoshi, H Nakagawa, M Kitahara, T Yamashita, K Arai, H Sunagozaka, N Iida, K Fushimi, S Kaneko.
    • Journal Title

      Cancer Lett.

      Volume: 369 Pages: 242-249

    • DOI

      10.1016/j.canlet.2015.08.020

    • NAID

      120005682640

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Defeating EpCAM(+) liver cancer stem cells by targeting chromatin remodeling enzyme CHD4 in human hepatocellular carcinoma.2015

    • Author(s)
      Nio K, Yamashita T, Okada H, Kondo M, Hayashi T, Hara Y, Nomura Y, Zeng SS, Yoshida M, Hayashi T, Sunagozaka H, Oishi N, Honda M, Kaneko S
    • Journal Title

      J. Hepatol.

      Volume: 5 Pages: 1164-1172

    • DOI

      10.1016/j.jhep.2015.06.009

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Inhibition of microRNA-214 ameliorates hepatic fibrosis and tumor incidence in platelet-derived growth factor C transgenic mice.2015

    • Author(s)
      H Okada, M Honda, JS Campbell, K Takegoshi, Y Sakai, T Yamashita, T Shirasaki, R Takabatake, M Nakamura, T Tanaka, S Kaneko.
    • Journal Title

      Cancer Sci.

      Volume: 106 Pages: 1143-1152

    • DOI

      10.1111/cas.12730

    • NAID

      120005830608

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Immunological features of T cells induced by human telomerase reverse transcriptase-derived peptides in patients with hepatocellular carcinoma.2015

    • Author(s)
      E Mizukoshi, H Nakagawa, M Kitahara, T Yamashita, K Arai, H Sunagozaka, K Fushimi, E Kobayashi, H Kishi, A Muraguchi, S Kaneko.
    • Journal Title

      Cancer Lett.

      Volume: 364 Pages: 98-105

    • DOI

      10.1016/j.canlet.2015.04.031

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Response to Importance of confounding factors in assessing fatty acid compositions in patients with non-alcoholic steatohepatitis2015

    • Author(s)
      Yamada K, Mizukoshi E, Sunagozaka H, Arai K, Yamashita T, Takeshita Y, Misu H, Takamura T, Kitamura S, Zen Y, Nakanuma Y, Honda M, Kaneko S
    • Journal Title

      Liver Int.

      Volume: 35 Pages: 1773-1773

    • DOI

      10.1111/liv.12755

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Serum DHCR24 Auto-antibody as a new Biomarker for Progression of Hepatitis C.2015

    • Author(s)
      Ezzikouri S, Kimura K, Sunagozaka H, Kaneko S, Inoue K, Nishimura T, Hishima T, Kohara M, Tsukiyama-Kohara K.
    • Journal Title

      EBioMedicine

      Volume: Apr 13;2(6) Pages: 604-12

    • DOI

      10.1016/j.ebiom.2015.04.007

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Small tRNA-derived RNAs are increased and more abundant than microRNAs in chronic hepatitis B and C.2015

    • Author(s)
      Selitsky SR, Baran-Gale J, Honda M, Yamane D, Masaki T, Fannin EE, Guerra B, Shirasaki T, Shimakami T, Kaneko S, Lanford RE, Lemon SM, Sethupathy P.
    • Journal Title

      Sci Rep

      Volume: 5 Pages: 7675-7675

    • DOI

      10.1038/srep07675

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between Serum Uric Acid Levels and Chronic Kidney Disease in a Japanese Cohort with Normal or Mildly Reduced Kidney Function.2015

    • Author(s)
      Toyama T, Furuichi K, Shimizu M, Hara A, Iwata Y, Sakai N, Perkovic V, Kobayashi M, Mano T, Kaneko S, Wada T.
    • Journal Title

      PLOS ONE

      Volume: 10

    • DOI

      10.1371/journal.pone.0137449

    • NAID

      120005680030

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Hepatocellular Carcinoma with β-Catenin Mutation: Imaging and Pathologic Characteristics.2015

    • Author(s)
      Kitao A, Matsui O, Yoneda N, Kozaka K, Kobayashi S, Sanada J, Koda W, Minami T, Inoue D, Yoshida K, Yamashita T, Yamashita T, Kaneko S, Takamura H, Ohta T, Ikeda H, Nakanuma Y, Kita R, Gabata T.
    • Journal Title

      Radiology

      Volume: 275 Pages: 708-17

    • DOI

      10.1148/radiol.14141315

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Autoantibody status and histological variables influence biochemical response to treatment and long-term outcomes in Japanese patients with primary biliary cirrhosis.2015

    • Author(s)
      Nakamura M, Kondo H, Tanaka A, Komori A, Ito M, Yamamoto K, Ohira H, Zeniya M, Hashimoto E, Honda M, Kaneko S, Ueno Y, Kikuchi K, Shimoda S, Harada K, Arai K, Miyake Y, Abe M, Taniai M, Saibara T, Sakisaka S, Takikawa H, Onji M, Tsubouchi H, Nakanuma Y, Ishibashi H.
    • Journal Title

      Hepatol Res

      Volume: - Pages: 846-855

    • DOI

      10.1111/hepr.12423

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Liver steatosis is associated with insulin resistance in skeletal muscle rather than in the liver in Japanese patients with non-alcoholic fatty liver disease.2015

    • Author(s)
      Kato K, Takeshita Y, Misu H, Zen Y, Kaneko S, Takamura T.
    • Journal Title

      J Diabetes Investig

      Volume: 6 Pages: 158-163

    • DOI

      10.1111/jdi.12271

    • NAID

      120005593987

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Characteristics of hepatic fatty acid compositions in patients with nonalcoholic steatohepatitis.2015

    • Author(s)
      Yamada K, Mizukoshi E, Sunagozaka H, Arai K, Yamashita T, Takeshita Y, Misu H, Takamura T, Kitamura S, Zen Y, Nakanuma Y, Honda M, Kaneko S.
    • Journal Title

      Liver Int

      Volume: 35(2) Pages: 580-590

    • DOI

      10.1111/liv.12685

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells.2014

    • Author(s)
      Ishikura K, Misu H, Kumazaki M, Takayama H, Matsuzawa-Nagata N, Tajima N, Chikamoto K, Lan F, Ando H, Ota T, Sakurai M, Takeshita Y, Kato K, Fujimura A, Miyamoto K, Saito Y, Kameo S, Okamoto Y, Takuwa Y, Takahashi K, Kidoya H, Takakura N, Kaneko S, Takamura T
    • Journal Title

      Diabetologia.

      Volume: 57 Pages: 1968-1976

    • DOI

      10.1007/s00125-014-3306-9

    • NAID

      120005463349

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance2014

    • Author(s)
      Fei Lan, H Misu, K Chikamoto, H Takayam, A Kikuchi, K Mohri, N Takata, H Hayashi, N Matsuzawa-Nagata, Y Takeshita, H Noda, Y Matsumoto, T Ota, T Nagano, M Nakagen, K Miyamoto, K Takatsuki, T Seo, K Iwayama, K Tokuyama, S Matsugo, H Tang, Y Saito, S Yamagoe, S Kaneko, T Takamura
    • Journal Title

      Diabetes

      Volume: 63 Pages: 1649-1664

    • DOI

      10.2337/db13-0728

    • NAID

      120005440333

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism : a randomised controlled trial2014

    • Author(s)
      Y Takeshita, T Takamura, M Honda, Y Kita, Y Zen, KI Kato, H Misu, T Ota, M Nakamura, K Yamada, H Sunagozaka, K Arai, T Yamashita, E Mizukoshi, S Kaneko
    • Journal Title

      Diabetologia.

      Volume: 57(5) Pages: 1649-1664

    • DOI

      10.1007/s00125-013-3149-9

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Remarks] 金沢大学医学部付属病院内科(旧第一内科)、金沢大学大学院先進予防医学研究科(システム生物学分野)

    • URL

      http://www.m-kanazawa.jp/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 金沢大学医学部付属病院内科(旧第一内科)

    • URL

      http://www.m-kanazawa.jp/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 金沢大学医学部付属病院内科(旧第一内科)恒常性制御学講座

    • URL

      http://www.m-kanazawa.jp/

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 肝硬変の診断方法、非アルコール性脂肪肝炎及び肝細胞がんの合併症の診断方法並びに非アルコール性脂肪肝炎及び食道胃静脈瘤の合併症の診断方法2018

    • Inventor(s)
      金子周一、本多政夫、川口和紀
    • Industrial Property Rights Holder
      金沢大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 非アルコール性脂肪性肝炎治療剤2018

    • Inventor(s)
      金子周一、酒井佳夫
    • Industrial Property Rights Holder
      金沢大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 線維化抑制剤2017

    • Inventor(s)
      金子周一、本多政夫、岡田光
    • Industrial Property Rights Holder
      金沢大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗がん剤及び新規医薬のスクリーニング方法2017

    • Inventor(s)
      山下太郎、金子周一、本多政夫、清木元治、岡田光
    • Industrial Property Rights Holder
      金沢大学、興和株式会社
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 肝細胞癌株、およびそれを用いた肝細胞癌発症動物モデル2017

    • Inventor(s)
      金子周一、本多政夫、山下太郎、岡田光、村居和寿
    • Industrial Property Rights Holder
      金沢大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 非アルコール性脂肪性肝炎検出方法、該肝炎の重篤度判定方法及び該肝炎の治療評価判定方法2017

    • Inventor(s)
      酒井佳夫、金子周一、餅田初音
    • Industrial Property Rights Holder
      金沢大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017-02-17
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 肝組織修復剤2017

    • Inventor(s)
      酒井佳夫、金子周一、餅田初音
    • Industrial Property Rights Holder
      金沢大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017-03-01
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 線維化抑制剤2016

    • Inventor(s)
      金子周一、本多政夫、岡田光
    • Industrial Property Rights Holder
      金沢大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-07-25
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] オリゴヌクレオチドが結合したビーズの作製方法2015

    • Inventor(s)
      橋本真一、金子周一
    • Industrial Property Rights Holder
      金沢大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-04-07
    • Related Report
      2015 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 2型糖尿病患者の治療薬選択の補助方法,治療薬の効果予測方法及び検査方法2015

    • Inventor(s)
      御簾博文、竹下有美枝、篁 俊成、金子周一
    • Industrial Property Rights Holder
      金沢大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-09-10
    • Related Report
      2015 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 抗DHCR24自己抗体検出による病態診断系2015

    • Inventor(s)
      金子周一、小原恭子、小原道法、木村公則
    • Industrial Property Rights Holder
      金沢大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-07-16
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 細胞障害性T細胞の作製方法2015

    • Inventor(s)
      金子周一、水腰英四郎、中河秀俊、村口 篤、岸 裕幸、小林栄治
    • Industrial Property Rights Holder
      金沢大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-10-23
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗B型肝炎ウイルス薬2015

    • Inventor(s)
      橋本真一、金子周一、本多政夫、白崎尚芳、山下太郎
    • Industrial Property Rights Holder
      金沢大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-11-09
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 2型糖尿病患者の治療薬選択の補助方法,治療薬の効果予測方法及び検査方法2014

    • Inventor(s)
      御簾 博文、竹下 有美枝、篁 俊成、金子 周一
    • Industrial Property Rights Holder
      金沢大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-09-10
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 急性肝炎治療剤及び代謝異常治療剤2014

    • Inventor(s)
      酒井 佳夫、金子 周一、関 晃裕、吉田 佳子、大和 雅敏
    • Industrial Property Rights Holder
      金沢大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-07-10
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2020-03-30  

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