Host nuclear network responsible for the pathology of virus infection
| Project/Area Number |
26253083
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Akita University |
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Principal Investigator |
IMAI Yumiko 秋田大学, 医学(系)研究科(研究院), 教授 (50231163)
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| Co-Investigator(Kenkyū-buntansha) |
白髭 克彦 東京大学, 分子細胞生物学研究所, 教授 (90273854)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥41,730,000 (Direct Cost: ¥32,100,000、Indirect Cost: ¥9,630,000)
Fiscal Year 2016: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
Fiscal Year 2015: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
Fiscal Year 2014: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
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| Keywords | ウィルス / 集中治療 / エピゲノム / ウイルス / ゲノム / インフルエンザ / 染色体 / エピジェネティクス / 核内ネットワーク |
|---|
| Outline of Final Research Achievements |
We investigated the mechanisms involved in the pathology of severe influenza virus infection focusing virus host nuclear interactions. We found a influenza virus RNA specific RNA nuclear export pathway mediated by NXF1. Also, we found that host epigenetic modifications in particular histone methylation play critical role in controlling the pathology of influenza virus infection, which could be a potential therapeutic target for severe influenza.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] ELABELA-APJ axis protects from pressure overload heart failure and angiotensin II-induced cardiac damage2017
Author(s)
Sato T, Sato C, Kadowaki A, Watanabe H, Ho L, Ishida J, Yamaguchi T, Kimura A, Fukamizu A, Penninger JM, Reversade B, Ito H, Imai Y, Kuba K
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Journal Title
Cardiovasc Res
Volume: 113(7)
Issue: 7
Pages: 760-769
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy.2017
Author(s)
Kimura H, Eguchi S, Sasaki J, Kuba K, Nakanishi H, Takasuga S, Yamazaki M, Goto A, Watanabe H, Itoh H, Imai Y, Suzuki A, Mizushima N, Sasaki T
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Journal Title
JCI Insight
Volume: 2
Issue: 1
Pages: 89462-89478
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment2016
Author(s)
Blank T, Detje CN, Spieß A, Hagemeyer N, Brendecke SM, Wolfart J, Staszewski O, Zöller T, Papageorgiou I, Schneider J, Paricio-Montesinos R, Eisel UL, Manahan-Vaughan D, Jansen S, Lienenklaus S, Lu B, Imai Y, Müller M, Goelz SE, Baker DP, Schwaninger M, Kann O, Heikenwalder M, Kalinke U, Prinz M
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Journal Title
Immunity
Volume: 44(4)
Issue: 4
Pages: 901-12
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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