| Budget Amount *help |
¥41,730,000 (Direct Cost: ¥32,100,000、Indirect Cost: ¥9,630,000)
Fiscal Year 2017: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2016: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2015: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2014: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
|
|---|
| Outline of Final Research Achievements |
Musculoskeletal diseases are rapidly increasing with the aging of society, and therefore, establishment of "coping method based on bone formation" is urgent, but "molecular mechanism of osteogenic control leading to regulation failure in diseased pathology of decreased osteogenesis" including reduction of bone mass due to decrease in mechanical stimulus is still not clear enough. We discovered the role of Nck as a molecular mechanism by which bone mass is regulated by the movement of osteoblasts is elucidated (PNAS 2015), control of TGFbeta signal by Dullard during endochondral bone formation (JBMR 2015), and function of osteoclastic TPC (JBC 2017). In addition, regulation of adrenergic receptors by PTH, isoproterenol regulation of osteoblastic ALP , osteoblast proliferation promoting action through UPS by PTH and molecular mechanism of oxidative stress control of osteoblasts were established. These discoveries contribute to understand the molecular mechanism of bone formation.
|
