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Molecular Mechanism of Comprehensive Signal for Bone Formation

Research Project

Project/Area Number 26253085
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional basic dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

NODA Masaki  東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 (50231725)

Co-Investigator(Kenkyū-buntansha) 江面 陽一  東京医科歯科大学, 難治疾患研究所, 准教授 (50333456)
早田 匡芳  筑波大学, 医学医療系, 准教授 (40420252)
伊豆 弥生  千葉科学大学, 危機管理学部, 講師 (90431949)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥41,730,000 (Direct Cost: ¥32,100,000、Indirect Cost: ¥9,630,000)
Fiscal Year 2017: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2016: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2015: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2014: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Keywords骨芽細胞 / 破骨細胞 / 骨形成 / メカニカルストレス / 骨量 / シグナル / Bardet-Biedl Syndrome 3 / 繊毛 / 骨代謝 / 副甲状腺ホルモン
Outline of Final Research Achievements

Musculoskeletal diseases are rapidly increasing with the aging of society, and therefore, establishment of "coping method based on bone formation" is urgent, but "molecular mechanism of osteogenic control leading to regulation failure in diseased pathology of decreased osteogenesis" including reduction of bone mass due to decrease in mechanical stimulus is still not clear enough. We discovered the role of Nck as a molecular mechanism by which bone mass is regulated by the movement of osteoblasts is elucidated (PNAS 2015), control of TGFbeta signal by Dullard during endochondral bone formation (JBMR 2015), and function of osteoclastic TPC (JBC 2017). In addition, regulation of adrenergic receptors by PTH, isoproterenol regulation of osteoblastic ALP , osteoblast proliferation promoting action through UPS by PTH and molecular mechanism of oxidative stress control of osteoblasts were established. These discoveries contribute to understand the molecular mechanism of bone formation.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (15 results)

All 2018 2017 2016 2015 2014

All Journal Article (12 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 11 results,  Open Access: 5 results,  Acknowledgement Compliant: 5 results) Presentation (3 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Dullard deficiency causes hemorrhage in the adult ovarian follicles2018

    • Author(s)
      Hayata Tadayoshi、Chiga Masahiko、Ezura Yoichi、Asashima Makoto、Katabuchi Hidetaka、Nishinakamura Ryuichi、Noda Masaki
    • Journal Title

      Genes to Cells

      Volume: 23 Issue: 5 Pages: 345

    • DOI

      10.1111/gtc.12575

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dok-3 and Dok-1/-2 adaptors play distinctive roles in cell fusion and proliferation during osteoclastogenesis and cooperatively protect mice from osteopenia2018

    • Author(s)
      Kajikawa Shuhei、Taguchi Yuu、Hayata Tadayoshi、Ezura Yoichi、Ueta Ryo、Arimura Sumimasa、Inoue Jun-ichiro、Noda Masaki、Yamanashi Yuji
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 498 Issue: 4 Pages: 967-974

    • DOI

      10.1016/j.bbrc.2018.03.090

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FGF Suppresses Poldip2 Expression in Osteoblasts2017

    • Author(s)
      Katsumura Sakie、Izu Yayoi、Yamada Takayuki、Griendling Kathy、Harada Kiyoshi、Noda Masaki、Ezura Yoichi
    • Journal Title

      Journal of Cellular Biochemistry

      Volume: 118 Issue: 7 Pages: 1670-1677

    • DOI

      10.1002/jcb.25813

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Role of lysosomal channel protein TPC2 in osteoclast differentiation and bone remodeling under normal and low-magnesium conditions.2017

    • Author(s)
      Notomi Takuya, Kuno M, Hiyama A, Nozaki T, Ohura K, Ezura Y, Noda M,
    • Journal Title

      J Biol Chem

      Volume: 292 Issue: 51 Pages: 20998-21010

    • DOI

      10.1074/jbc.m117.780072

    • NAID

      130007900094

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Profilin1 is expressed in osteocytes and regulates cell shape and migration.2017

    • Author(s)
      Lin W, Izu Y, Smriti A, Kawasaki M, Pawaputanon C, Bottcher RT, Costell M, Moriyama K, Noda M, Ezura Y.
    • Journal Title

      J Cell Physiol.

      Volume: 印刷中 Issue: 1 Pages: 259-268

    • DOI

      10.1002/jcp.25872

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Bardet-Biedl Syndrome 3 regulates development of cranial base midline structures.2016

    • Author(s)
      Kawasaki M, Izu Y, Hayata T, Ideno H, Nifuji A, Sheffield VC, Ezura Y, Noda M
    • Journal Title

      BONE

      Volume: ー

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Interleukin-1β Suppresses the Transporter Genes Ank and Ent1 Expression in Stromal Progenitor Cells Retaining Mineralization.2016

    • Author(s)
      Ezura Y, Lin X, Hatta A, Izu Y, Noda M.
    • Journal Title

      Calcif Tissue Int.

      Volume: 99 Issue: 2 Pages: 199-208

    • DOI

      10.1007/s00223-016-0139-1

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] PTH-Induced Osteoblast Proliferation Requires Upregulation of the Ubiquitin-Specific Peptidase 2 (Usp2) Expression.2016

    • Author(s)
      Shirakawa J, Harada H, Noda M, Ezura Y.
    • Journal Title

      Calcif Tissue Int.

      Volume: 98 Issue: 3 Pages: 306-315

    • DOI

      10.1007/s00223-015-0083-5

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Nck influences preosteoblastic/osteoblastic migration and bone mass2015

    • Author(s)
      Aryal Smriti, Kentaro Miyai, Yayoi Izu, Tadayoshi Hayata, Takuya Notomi, Masaki Noda, Yoichi Ezura
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 112 Issue: 50 Pages: 15432-7

    • DOI

      10.1073/pnas.1518253112

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Migration linked to FUCCI-indicated cell cycle is controlled by PTH and mechanical stress†2014

    • Author(s)
      Shirakawa J, Ezura Y, Moriya S, Kawasaki M, Yamada T, Notomi T, Nakamoto T, Hayata T, Miyawaki A, Omura K, Noda M.
    • Journal Title

      Journal of Cellular Physiology

      Volume: - Issue: 10 Pages: 1353-8

    • DOI

      10.1002/jcp.24605

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hindlimb-unloading suppresses B cell population in the bone marrow and peripheral circulation associated with OPN expression in circulating blood cells.2014

    • Author(s)
      Ezura Y1, Nagata J, Nagao M, Hemmi H, Hayata T, Rittling S, Denhardt DT, Noda M.
    • Journal Title

      J Bone Miner Metab.

      Volume: 33 Issue: 1 Pages: 48-54

    • DOI

      10.1007/s00774-014-0568-8

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Insulinogenic sucrose+amino acid mixture ingestion immediately after resistance exercise has an anabolic effect on bone compared with non-insulinogenic fructose+amino acid mixture in growing rats.2014

    • Author(s)
      Notomi T, Karasaki I, Okazaki Y, Okimoto N, Kato Y, Ohura K, Noda M, Nakamura T, Suzuki M.
    • Journal Title

      Bone

      Volume: 65 Issue: 13 Pages: 42-48

    • DOI

      10.1084/jem.20141132

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Oxidative stress impairs the expression levels of of Lgr4 in osteoblastic cells.2016

    • Author(s)
      Chantida Pawaputanon Na Mahasarakham, Yoichi Ezura, Yayoi Izu, Katsuhiko Nishimori, Yuichi Izumi, Masaki Nada.
    • Organizer
      The 38th Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Atlanta, Georgia, U.S.A.
    • Year and Date
      2016-09-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Changes in Membrane Potential Regulates RANKL Intracellular Transport via Voltage-gated Calcium Channels in Osteoblasts.2016

    • Author(s)
      Takuya Notomi, Miyuki Kuno, Akiko Hiyama, Yoichi Ezura, Kiyoshi Ohura, Masaki Noda.
    • Organizer
      The 38th Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Atlanta, Georgia, U.S.A.
    • Year and Date
      2016-09-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dexamethasone-induced Poldip2 expression possibly recapitulating the osteoblast aging was suppressed by a longevity factor basic-FGF.2016

    • Author(s)
      Sakie Katsumura, Yoichi Ezura, Kathy Griendling, Masaki Noda.
    • Organizer
      The 38th Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Atlanta, Georgia, U.S.A.
    • Year and Date
      2016-09-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research

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Published: 2014-04-04   Modified: 2019-03-29  

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