| Project/Area Number |
26253086
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Azuma Miyuki 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (90255654)
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| Co-Investigator(Kenkyū-buntansha) |
永井 重徳 東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 (50348801)
大野 建州 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (80435635)
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| Co-Investigator(Renkei-kenkyūsha) |
TOMURA Michio 大阪大谷大学, 薬学部, 教授 (30314321)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2016: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Fiscal Year 2015: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Fiscal Year 2014: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
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| Keywords | 免疫制御 / 口腔粘膜 / 免疫チェックポイント分子 / 粘膜上皮細胞 / T細胞 / 接触過敏症 / 免疫学 / 歯学 / 樹状細胞 / 口腔癌 / 免疫寛容 / 免疫抑制 / 歯髄 |
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| Outline of Final Research Achievements |
We investigated characteristic immune regulation in the oral cavity using murine experimental models. Masticatory mucosae, such as the dorsal tongue, gingiva, and hard palate, physiologically expressed the immune checkpoint molecule B7-H1 and this was enhanced by various topical stimuli. We demonstrated that B7-H1 expressed on the oral mucosa directly contributed to the regulation of CD4 and CD8 T cells responding to exogenous antigens and allergens. We also found that in a contact hypersensitivity (CH) model, oral CH was more rapid and more severe, but quickly declined by the PD-1:B7-H1-mediated regulation.
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