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Development of tooth regeneration technology based on the clarification of mechanism of tooth development.

Research Project

Project/Area Number 26253088
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Prosthodontics/ Dental materials science and
Research InstitutionOkayama University

Principal Investigator

Kuboki Takuo  岡山大学, 医歯薬学総合研究科, 教授 (00225195)

Co-Investigator(Kenkyū-buntansha) 大島 正充  岡山大学, 医歯薬学総合研究科, 助教 (00548307)
辻 孝  国立研究開発法人理化学研究所, 多細胞システム形成研究センター, チームリーダー (50339131)
大野 充昭  岡山大学, 医歯薬学総合研究科, 助教 (60613156)
淺原 弘嗣  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (70294460)
秋山 謙太郎  岡山大学, 大学病院, 講師 (70423291)
内部 健太  岡山大学, 医歯薬学総合研究科, 助教 (20584618)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2017: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2016: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2015: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2014: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Keywords歯の再生 / 器官原基法 / 再生歯学 / 歯 / 幹細胞 / 発生 / 歯科補綴学一般 / 発生・再生 / 細胞生物学 / 再生
Outline of Final Research Achievements

Whole-tooth regeneration therapy has great potential for the replacement of lost teeth.Recently, our group have been reported an in vitro three-dimensional cell manipulation method called the bioengineered organ germ method. However, it is unclear the mechanism of tooth development. Therefore, we performed the comprehensive analysis and could narrow down the several candidate genes. In the future, we are planing to perform the functional analysis of these candidate genes.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (52 results)

All 2018 2017 2016 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (24 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 23 results,  Open Access: 13 results,  Acknowledgement Compliant: 4 results) Presentation (21 results) (of which Int'l Joint Research: 6 results,  Invited: 8 results) Book (4 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] Harvard Univ./Dept. Developmental Biology(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Type IV collagen α6 chain is a regulator of keratin 10 in keratinization of oral mucosal epithelium2018

    • Author(s)
      Komori T, Ono M, Hara ES, Ueda J, Nguyen HTT, Nguyen HT, Yonezawa T, Maeba T, Ono A, Takarada T, Momota R, Maekawa K, Kuboki T, Oohashi T
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 2612-2612

    • DOI

      10.1038/s41598-018-21000-0

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CCN4/WISP1 controls cutaneous wound healing by modulating proliferation, migration and ECM expression in dermal fibroblasts via α5β1 and TNFα.2018

    • Author(s)
      Ono M, Masaki A, Maeda A, Kilts TM, Hara ES, Komori T, Pham H, Kuboki T, Young MF.
    • Journal Title

      Matrix Biol.

      Volume: 17 Pages: 30400-6

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Tetrathiomolybdate enhances the antitumor effect of cetuximab via the suppression of osteoclastogenesis in head and neck squamous carcinoma.2018

    • Author(s)
      Morisawa A, Okui T, Shimo T, Ibaragi S, Okusha Y, Ono M, Nguyen TTH, Hassan NMM, Sasaki A.
    • Journal Title

      International Journal of Oncology

      Volume: 52 Pages: 989-999

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A multi-centered epidemiological study evaluating the validity of the treatment difficulty indices developed by the Japan Prosthodontic Society2018

    • Author(s)
      Kuboki T, Ichikawa T, Baba K, Fujisawa M, Sato H, Aita H, Koyama S, Hideshima M, Sato Y, Wake H, Kimura-Ono A, Nagao K, Kodaira-Ueda Y, Tamaki K, Sadamori S, Tsuga K, Nishi Y, Sawase T, Koshino H, Masumi SI, Sakurai K, Ishibashi K, Ohyama T, Akagawa Y, Hirai T, Sasaki K, Koyano K, Yatani H, Matsumura H.
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 62 Issue: 2 Pages: 162-170

    • DOI

      10.1016/j.jpor.2017.08.002

    • NAID

      130006733088

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MCSF orchestrates branching morphogenesis in developing submandibular gland tissue.2017

    • Author(s)
      Sathi GA, Farahat M, Hara ES, Taketa H, Nagatsuka H, Kuboki T, Matsumoto T.
    • Journal Title

      Journal of Cell Science

      Volume: 130 Pages: 1559-1569

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Practical whole-tooth restoration utilizing autologous bioengineered tooth germ transplantation in a postnatal canine model.2017

    • Author(s)
      Ono M, Oshima M, Ogawa M, Sonoyama W, Hara ES, Oida Y, Shinkawa S, Nakajima R , Mine A ,Hayano S, Fukumoto S , Kasugai8 S , Yamaguchi A, Tsuji T, Kuboki T
    • Journal Title

      Sci Rep

      Volume: 7 Issue: 1 Pages: 44522-44522

    • DOI

      10.1038/srep44522

    • NAID

      120006535050

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cellular reprogramming using defined factors and microRNAs.2016

    • Author(s)
      Eguchi T, Kuboki T.
    • Journal Title

      Stem Cells International

      Volume: 2016 Issue: 1 Pages: 7530942-7530942

    • DOI

      10.1155/2016/7530942

    • NAID

      120006489932

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bioengineering a 3D integumentary organ system from iPS cells using an in vivo transplantation model2016

    • Author(s)
      1Ryoji Takagi, Junko Ishimaru, Ayaka Sugawara, Koh-ei Toyoshima, Kentaro Ishida, Miho Ogawa, Kei Sakakibara, Kyosuke Asakawa, Akitoshi Kashiwakura, Masamitsu Oshima, Ryohei Minamide, Akio Sato, Toshihiro Yoshitake, Akira Takeda, Hiroshi Egusa & Takashi Tsuji
    • Journal Title

      Science Advances

      Volume: 2(4) Issue: 4 Pages: 1-10

    • DOI

      10.1126/sciadv.1500887

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Development of a functional biohybrid implant formed from periodontal tissue utilizing bioengineering technology.2016

    • Author(s)
      Nakajima K, Oshima M, Yamamoto N, Tanaka C, Koitabashi R, Inoue T, Tsuji T.
    • Journal Title

      Tissue Engineering Part A.

      Volume: 22(17-18) Issue: 17-18 Pages: 1108-1115

    • DOI

      10.1089/ten.tea.2016.0130

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 間葉系幹細胞の新しい機能-免疫調節細胞としての間葉系幹細胞-.2016

    • Author(s)
      秋山謙太郎,古味佳子,窪木拓男.
    • Journal Title

      日本補綴歯科学会誌

      Volume: 8(4) Pages: 346-353

    • NAID

      130005279570

    • Related Report
      2016 Annual Research Report
  • [Journal Article] In silico Comparison of the Reproducibility of Full-arch Implant Provisional Restorations to Final Restoration between a 3D Scan/CAD/CAM Technique and the Conventional Method.2015

    • Author(s)
      Mino T, Maekawa K, Ueda A, Higuchi S, Sejima J, Takeuchi T, Hara ES, Kimura-Ono A, Sonoyama W, Kuboki T.
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 59(2) Pages: 152-158

    • NAID

      130007936670

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Topical application of lithium chloride on the pulp induces dentin regeneration.2015

    • Author(s)
      Ishimoto K, Hayano S, Yanagita T, Kurosaka H, Kawanabe N, Itoh S, Ono M, Kuboki T, Kamioka H, Yamashiro T.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 3 Pages: 1-12

    • DOI

      10.1371/journal.pone.0121938

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Peptide-modified Substrate for Modulating Gland Tissue Growth and Morphology In Vitro2015

    • Author(s)
      Taketa H, Sathi GA, Farahat M, Rahman KA, Sakai T, Hirano Y, Kuboki T, Torii Y, Matsumoto T
    • Journal Title

      Sci Rep

      Volume: 5 Issue: 1 Pages: 11468-11468

    • DOI

      10.1038/srep11468

    • NAID

      120005697272

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Fluocinolone Acetonide Is a Potent Synergistic Factor of TGF-β3-associated Chondrogenesis of Bone Marrow-derived Mesenchymal Stem Cells for Articular Surface Regeneration.2015

    • Author(s)
      Hara ES, Ono M, Pham HT, Sonoyama W, Kubota S, Takigawa M, Matsumoto T, Young MF, Olsen BR, Kuboki T.
    • Journal Title

      Jounal of Bone and Mineral Research

      Volume: 30(9) Pages: 1585-1596

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] CCN4/WISP-1 Positively Regulates Chondrogenesis by Controlling TGF-β3 Function.2015

    • Author(s)
      Yoshioka Y, Ono M, Maeda A, Kilts TM, Hara ES, Khattab H, Ueda J, Aoyama E, Oohashi T, Takigawa M, Young MF, Kuboki T.
    • Journal Title

      Bone

      Volume: 22(5) Pages: 162-170

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A short-term treatment with tumor necrosis factor-alpha enhances stem cell phenotype of human dental pulp cells2014

    • Author(s)
      Mayu Ueda, Takuo Fujisawa, Mitsuaki Ono, Emilio Satoshi Hara, Hai Thanh Pham, Ryu Nakajima, Wataru Sonoyama, Takuo Kuboki
    • Journal Title

      Stem Cell Research & Therapy

      Volume: 5 Issue: 1 Pages: 31-31

    • DOI

      10.1186/scrt420

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Functional tooth restoration by next-generation bio-hybrid implant as a bio-hybrid artificail organ replacement therapy2014

    • Author(s)
      M.Oshima, K.Nakajima, T.Inoue, T.Tsuji, et al
    • Journal Title

      Scientific Reports

      Volume: 4 Issue: 1 Pages: 1-10

    • DOI

      10.1038/srep06044

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Mesenchymal stem/progenitor cell isolation from tooth extraction sockets.2014

    • Author(s)
      Nakajima R, Ono M, Hara ES, Oida Y, Shinkawa S, Pham HT, Akiyama K, Sonoyama W, Maekawa K, Kuboki T.
    • Journal Title

      Journal of Dental Research

      Volume: 93(11) Pages: 1133-1140

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The BMP2 antagonist inhibitor L51P enhances the osteogenic potential of BMP2 by simultaneous and delayed synergism.2014

    • Author(s)
      Khattab HM, Ono M, Sonoyama W, Oida Y, Shinkawa S, Yoshioka Y, Maekawa K, Tabata Y, Sugama K, Sebald W, Kuboki T.
    • Journal Title

      Bone

      Volume: 69 Pages: 165-173

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regeneration of calvarial defects with Escherichia coli-derived rhBMP-2 adsorbed in PLGA membrane.2014

    • Author(s)
      Ono M, Sonoyama W, Nema K, Hara ES, Oida Y, Pham HT, Yamamoto K, Hirota K, Sugama K, Sebald W, Kuboki T.
    • Journal Title

      Cells Tissues Organs

      Volume: 198(5) Pages: 367-376

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient bone formation in swine socket-lift model using E. coli-derived rhBMP-2 adsorbed in β-TCP.2014

    • Author(s)
      Ono M, Sonoyama W, Yamamoto K, Oida Y, Akiyama K, Shinkawa S, Nakajima R, Pham HT, Hara ES, Kuboki T.
    • Journal Title

      Cells Tissues Organs

      Volume: 199(4) Pages: 249-255

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional tooth regenerative therapy: tooth tissue regeneration and whole-tooth replacement.2014

    • Author(s)
      Masamitsu Oshima, Takashi Tsuji
    • Journal Title

      Odontlogy

      Volume: 102 Issue: 2 Pages: 123-136

    • DOI

      10.1007/s10266-014-0168-z

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Whole tooth regeneration using a bioengineered tooth.2014

    • Author(s)
      Masamitsu Oshima and Takashi Tsuji
    • Journal Title

      New Trends in Tissue Engineering and Regenerative Medicine - Official Book of the Japanese Society for Regenerative Medicine, Edited by Hideharu Hibi and Minoru Ueda

      Volume: - Pages: 1-5

    • DOI

      10.5772/58908

    • ISBN
      9789535117247
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The junctional epithelium originates from the odontogenic epithelium of an erupted tooth.2014

    • Author(s)
      Sara Yajima-Himuro, Masamitsu Oshima, Gou Yamamoto, Miho Ogawa, Madoka Furuya, Junichi Tanaka, Kousuke Nishii, Kenji Mishima, Tetsuhiko Tachikawa, Takashi Tsuji, Matsuo Yamamoto
    • Journal Title

      Scientific Reports

      Volume: 4(4867) Issue: 1 Pages: 1-7

    • DOI

      10.1038/srep04867

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Biological regenerative medicine in prosthodontic practice -to attain reliable and sophisticated dental implant therapy.2017

    • Author(s)
      Kuboki T.
    • Organizer
      SNU Graduate School of Dentistry, Special Lecture.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Collaboration between soft tissue management and oral implant therapy to attain optimum esthetic results.2017

    • Author(s)
      Kuboki T.
    • Organizer
      The International Odonto-Stomatology Conference 2017.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 必須アミノ酸Tryptophanは骨髄由来間葉系幹細胞の幹細胞性を制御し骨形成を促進する.2017

    • Author(s)
      大野充昭,Pham HT, 笈田育尚,小盛大志,土佐郁恵,大橋俊孝,秋山謙太郎,窪木拓男.
    • Organizer
      第47回公益社団法人日本口腔インプラント学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Regulation of gingival keratinization by laminin332.2017

    • Author(s)
      Komori T, Ueda J, Ono M, Sonoyama W, Hara ES, Yoshioka Y, Maekawa K, Kuboki T.
    • Organizer
      95th General Session & Exhibition of the IADR.
    • Related Report
      2017 Annual Research Report
  • [Presentation] BMP antagonist inhibitor L51P regulates the chondrogenesis and osteoarthritis.2017

    • Author(s)
      Nguyen HT, Ono M, Komori T, Oohashi T, Kuboki T.
    • Organizer
      The 65th Annual Meeting of JADR.
    • Related Report
      2017 Annual Research Report
  • [Presentation] Biological Regenerative Medicine in Prosthodontic Practice―to Attain Reliable and Sophisticated Dental Implant Therapy.2016

    • Author(s)
      Kuboki T
    • Organizer
      The 6th Conference on Dental Health, Haiphong University of Medicine and Pharmacy
    • Place of Presentation
      Haiphong, Vietnam
    • Year and Date
      2016-11-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 歯槽骨吸収に対する歯・歯周組織の包括的再生技術の開発.2016

    • Author(s)
      大島正充,辻 孝,窪木拓男.
    • Organizer
      第7回骨バイオサイエンス研究会.
    • Place of Presentation
      岡山, 日本
    • Related Report
      2016 Annual Research Report
  • [Presentation] 間葉系幹細胞の組織再生療法2015

    • Author(s)
      秋山謙太郎
    • Organizer
      第3回ARCOCSセミナー
    • Place of Presentation
      岡山,日本
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Effect of Tryptophan to Bone Marrow-derived Mesenchymal Stromal Cells on the Stemness and Osteogenesis in vitro and in vivo.2015

    • Author(s)
      Pham HT, Ono M, Hara ES, Oida Y, Nguyen HT, Akiyama K, Kuboki T.
    • Organizer
      The 36th Annual Meeting of the American Society for Bone and Mineral Research.
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2015-10-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A Novel Method to Induce Strong Chondrogenesis of BMSCs and Promote Articular Surface Repair using Fluocinolone Acetonide and TGF-β3.2015

    • Author(s)
      Hara ES, Ono M, Pham HT, Sonoyama W, Kubota S, Takigawa M, Young MF, Olsen BR, Matsumoto T, Kuboki T.
    • Organizer
      Biomedical Engineering Society 2015 Annual Meeting
    • Place of Presentation
      Tampa,USA
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] BMP2変異体L51Pは BMPネガティブ・フィードバック機構を制御することでBMP2誘導性骨芽細胞分化および骨形成を促進する.2015

    • Author(s)
      大野充昭,Khattab H,笈田育尚,Sebald W,窪木拓男.
    • Organizer
      第45回公益社団法人日本口腔インプラント学会・学術大会
    • Place of Presentation
      岡山,日本
    • Year and Date
      2015-09-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] CCN4/WISP1はWntシグナル経路を介して骨のリモデリングを制御する2015

    • Author(s)
      前田あずさ,大野充昭,窪木拓男,Young MF
    • Organizer
      第7回日本CCNファミリー研究会
    • Place of Presentation
      岡山,日本
    • Year and Date
      2015-08-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] Among Glucocorticoids, Fluocinolone Acetonide is Unique in Potentiating TGF-β3-mediated Chondrogenesis of BMSCs and Promoting Articular Cartilage Repair.2015

    • Author(s)
      Hara ES, 大野充昭, Pham HT, Young MF, 久保田 聡, 滝川正春, 窪木拓男.
    • Organizer
      第33回日本骨代謝学会学術集会
    • Place of Presentation
      東京,日本
    • Year and Date
      2015-07-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] The Combination of Fluocinolone Acetonide and TGF-β3 Promotes Strong Chondrogenesis of hBMSCs for Articular Surface Regeneration.2015

    • Author(s)
      Hara ES, 大野充昭, Pham HT, 園山 亘, 久保田 聡, 滝川正春, 松本卓也, Young MF, Olsen BR, 窪木拓男.
    • Organizer
      第6回骨バイオサイエンス研究会
    • Place of Presentation
      岡山,日本
    • Year and Date
      2015-07-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 幹細胞研究の現状と将来展望2015

    • Author(s)
      長澤丘司,玉井克人,秋山謙太郎
    • Organizer
      公益社団法人日本補綴歯科学会第124回学術大会
    • Place of Presentation
      埼玉,日本
    • Year and Date
      2015-05-31
    • Related Report
      2015 Annual Research Report
  • [Presentation] 歯科再生技術が導く歯・歯周組織の包括的再生2015

    • Author(s)
      大島正充
    • Organizer
      公益社団法人日本補綴歯科学会第124回学術大会
    • Place of Presentation
      埼玉,日本
    • Year and Date
      2015-05-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Biological Regenerative Medicine in Prothodontic Practice-to Attain Reliable and Sophisticated Dental Implant Therapy.2015

    • Author(s)
      Kuboki T.
    • Organizer
      5th Research Week-International Symposium of Oral Medicine, College of Oral Medicine, Taipei Medical University.
    • Place of Presentation
      Taipei,Taiwan
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Functional tooth regenerative therapy: tooth tissue regeneration and whole-tooth replacement.2014

    • Author(s)
      Oshima M
    • Organizer
      International Scientific Conference the 35th Foundation and Development Anniversary of Haiphong University of Medicine and Pharmacy.
    • Place of Presentation
      Haiphong, Vietnam
    • Year and Date
      2014-11-14 – 2014-11-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] miR-720 regulates the stem cell phenotype and differentiation of human dental pulp-derived mesenchymal stromal cells.2014

    • Author(s)
      Hara ES, Ono M, Eguchi T, Pham HT, Tajima S, Calderwood SK, Matsumoto T, Kuboki T.
    • Organizer
      25th 2014 International Symposium on Micro-NanoMechatronics and Human Science. (From Micro & Nano Scale Systems to Robotics & Mechatronics Systems)
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Biological Regenerative Medicine in Prosthodontic Practice - to attain Reliable and Sophisticated dental Implant therapy.2014

    • Author(s)
      Kuboki T
    • Organizer
      The Present and Future of Dental Implant.
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2014-10-30 – 2014-10-31
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 骨バイオサイエンスと幹細胞科学の融合2014

    • Author(s)
      窪木拓男
    • Organizer
      第5回骨バイオサイエンス研究会
    • Place of Presentation
      岡山,日本
    • Year and Date
      2014-06-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Book] Horizontal Alveolar Ridge Augmentation in Implant Dentistry, A Surgical Manual.2015

    • Author(s)
      Oshima M, Tsuji T.
    • Total Pages
      340
    • Publisher
      Wiley-Blackwell
    • Related Report
      2015 Annual Research Report
  • [Book] Engineering Mineralized and Load Bearing Tissues2015

    • Author(s)
      Oshima M, Tsuji T.
    • Total Pages
      276
    • Publisher
      Springer International Publishing.
    • Related Report
      2015 Annual Research Report
  • [Book] 高齢者におけるインプラント治療を考える.2014

    • Author(s)
      窪木拓男,大野 彩,園山 亘,荒川 光.
    • Total Pages
      175
    • Publisher
      日本歯科評論, 株式会社ヒョーロン・パブリッシャーズ
    • Related Report
      2014 Annual Research Report
  • [Book] Ⅲ.咬合・歯周組織の正常像と咬合・咀嚼障害.2014

    • Author(s)
      窪木拓男,前川賢治
    • Total Pages
      376
    • Publisher
      クラウンブリッジ補綴学第5版, 医歯薬出版株式会社
    • Related Report
      2014 Annual Research Report
  • [Remarks] 岡山大学大学院医歯薬学総合研究科インプラント再生補綴学分野ホームページ

    • URL

      http://www.okayama-u.ac.jp/user/implant/index.html

    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] キヌレニンを応用した骨折治療法2015

    • Inventor(s)
      窪木拓男,大野充昭 他
    • Industrial Property Rights Holder
      窪木拓男,大野充昭 他
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-11-18
    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2023-03-16  

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