Development of the inhibitor for cancer metastasis through Wnt signaling pathway by catenin-cadherin complex.

• Project/Area Number: 26253089
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Chiba University
• Principal Investigator: Hideki Tanzawa 千葉大学, 大学院医学研究院, 教授 (50236775)
• Co-Investigator(Kenkyū-buntansha): 小河原 克訓 千葉大学, 医学(系)研究科(研究院), 特任研究員 (20372360) ; 坂本 洋右 千葉大学, 医学部附属病院, 講師 (50451745)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000); Fiscal Year 2016: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000); Fiscal Year 2015: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000); Fiscal Year 2014: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
• Keywords: 臨床腫瘍学 / 癌転移 / β-catenin / WNT / cadherine / ALY遺伝子 / GAD1遺伝子 / HTR2C 遺伝子 / MMPｓ / 口腔扁平上皮癌 / 悪性黒色腫 / GAD1 / ALY / HTR2C / 発がん / がん遺伝子 / 浸潤・転移

Outline of Final Research Achievements

Elucidation of cancer metastasis mechanism and development of metastasis regulating drugs for cancer treatment are being conducted all over the world. However, no effective method of controlling metastasis has not found so far. In this study, we focused on the cell adhesion mechanism associated with β catenin among cancer metastasis mechanisms in the cell lines of oral squamous cell carcinoma (OSCC). Furthermore, we identified the metastasis inhibitors and determined their effects. As a result, we could identify three cascades involved in candidate drugs for cancer metastasis. Inhibition of cancer metastasis in vitro and in vivo could be achieved by suppressing these functions. Our results are considered to be very useful data for development of the metastasis suppressive treatment drugs for oral cancer.