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Establishment of the periodontitis onset risk rating system for the realization of predictive dentistry

Research Project

Project/Area Number 26253094
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Social dentistry
Research InstitutionOsaka University

Principal Investigator

Amano Atsuo  大阪大学, 歯学研究科, 教授 (50193024)

Co-Investigator(Kenkyū-buntansha) 久保庭 雅恵  大阪大学, 歯学研究科, 准教授 (00303983)
竹内 洋輝  大阪大学, 歯学研究科(研究院), 助教 (40572186)
小島 美樹  大阪大学, 歯学研究科(研究院), 助教 (20263303)
橋野 恵衣  大阪大学, 歯学部附属病院, 特任助教 (90614553)
Project Period (FY) 2014-06-27 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2017: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2016: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2015: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2014: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Keywords歯周炎 / P. gingivalis / バイオフィルム / メンブレントラフィック / 歯周病 / F. nucleatum / S. gordonii / 細胞内感染 / 予測歯科 / 発症リスク / 細胞内侵入 / 生活習慣 / メタボローム研究 / 歯学 / 細菌感染
Outline of Final Research Achievements

We analyzed the molecular basis involved in oral colonization of P. gingivalis. Coculture with P. gingivalis induced the secretions of arginine, agmatine and ornithine by F. alocis, which contributes to nutritional symbiosis of P. gingivalis. While, the pathogen is well known to invade host cells such as gingival epithelial cells. We showed that P. gingivalis was first internalized with early endosomes positive for Rab14 and RalA which are members of low molecular weitht GTP-binding proteins. Then, the intercellular pathogen was suggested to exploit these effector molecules for its intracellular inhabiting and exit from infected cells.
These findings suggest the molecular basis utilized by P. gingivalis for oral colonization.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (84 results)

All 2018 2017 2016 2015 2014 Other

All Int'l Joint Research (2 results) Journal Article (38 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 28 results,  Open Access: 11 results,  Acknowledgement Compliant: 13 results) Presentation (37 results) (of which Int'l Joint Research: 12 results,  Invited: 23 results) Book (4 results) Remarks (3 results)

  • [Int'l Joint Research] University of Louisville/School of Dentistry/Department of Oral Immunology(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Kyungpook National University/School of Dentistry/Department of Preventive Dentistry(韓国)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Zinc-finger transcription factor Odd-skipped related 1 regulates cranial bone formation2018

    • Author(s)
      Kawai Shinji、Yamauchi Masashi、Amano Atsuo
    • Journal Title

      Journal of Bone and Mineral Metabolism

      Volume: 31 Issue: 6 Pages: 640-647

    • DOI

      10.1007/s00774-017-0885-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell cycle arrest and apoptosis induced by Porphyromonas gingivalis requires JNK- and p53-mediated p38 activation in human trophoblasts2018

    • Author(s)
      Hiroaki Inaba, Atsuo Amano, Richard J. Lamont, Yukitaka Murakami, Michiyo Matsumoto-Nakano.
    • Journal Title

      Infection and Immunity

      Volume: in press Issue: 4

    • DOI

      10.1128/iai.00923-17

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] プラークの病原性を見分ける2018

    • Author(s)
      天野敦雄
    • Journal Title

      日本臨床矯正歯科医会雑誌

      Volume: 29 Pages: 8-12

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Syntaxin 4a regulates matrix vesicle-mediated bone matrix production by osteoblasts2017

    • Author(s)
      Kawai S*, Michikami I, Kitagaki J, Hata K, Kiyonari H, Abe T, Amano A, Wakisaka S
    • Journal Title

      Journal of Bone and Mineral Research

      Volume: 32 Issue: 3 Pages: 440-448

    • DOI

      10.1002/jbmr.3056

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct signatures of dental plaque metabolic byproducts dictated by periodontal inflammatory status.2017

    • Author(s)
      Sakanaka A, Kuboniwa M*, Hashino E, Bamba T, Fukusaki E, Amano A
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 42818-42818

    • DOI

      10.1038/srep42818

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between chewing ability and cognitive impairment in the rural elderly2017

    • Author(s)
      Kim Eun-Kyong、Lee Sung Kook、Choi Youn-Hee、Tanaka Makiko、Hirotsu Kimiko、Kim Hyeon Chang、Lee Hee-Kyung、Jung Yun-Sook、Amano Atsuo
    • Journal Title

      Archives of Gerontology and Geriatrics

      Volume: 70 Pages: 209-213

    • DOI

      10.1016/j.archger.2017.02.006

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Metabolic crosstalk regulates Porphyromonas gingivalis colonization and virulence during oral polymicrobial infection2017

    • Author(s)
      Kuboniwa Masae、Houser John R.、Hendrickson Erik L.、Wang Qian、Alghamdi Samar A.、Sakanaka Akito、Miller Daniel P.、Hutcherson Justin A.、Wang Tiansong、Beck David A. C.、Whiteley Marvin、Amano Atsuo、Wang Huizhi、Marcotte Edward M.、Hackett Murray、Lamont Richard J.
    • Journal Title

      Nature Microbiology

      Volume: 2 Issue: 11 Pages: 1493-1499

    • DOI

      10.1038/s41564-017-0021-6

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 歯周病と全身疾患2017

    • Author(s)
      天野敦雄
    • Journal Title

      CLINICAL CALCIUM

      Volume: 27 Pages: 1383-1391

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 歯周病が全身疾患に発症や進行に影響を与えるメカニズムについて2017

    • Author(s)
      天野敦雄
    • Journal Title

      CLINICAL CALCIUM

      Volume: 27 Pages: 1460-1461

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Intracellular periodontal pathogen exploits recycling pathway to exit from infected cells2016

    • Author(s)
      Takeuchi H, Takada A, Kuboniwa M, Amano A。
    • Journal Title

      Cellular Microbiology

      Volume: in press Issue: 7 Pages: 928-948

    • DOI

      10.1111/cmi.12551

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Apple- and hop-polyphenols inhibit Porphyromonas gingivalis-mediated proMMP9 activation and invasion of oral squamous cell carcinoma cells2016

    • Author(s)
      Inaba H*, Tagashira M, Kanda T, Murakami Y, Amano A, Matsumoto-Nakano M
    • Journal Title

      Journal of Periodontology

      Volume: 87 Issue: 9 Pages: 1103-1111

    • DOI

      10.1902/jop.2016.160047

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dual lifestyle of Porphyromonas gingivalis in biofilm and gingival cells2016

    • Author(s)
      Sakanaka A, Takeuchi H, Kuboniwa M, Amano A*
    • Journal Title

      Microbial Pathogenesis

      Volume: 94 Pages: 42-47

    • DOI

      10.1016/j.micpath.2015.10.003

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)2016

    • Author(s)
      Klionsky DJ., Abdelmohsen K., Abe A., Abedin MJ.,Inomata M., et al.
    • Journal Title

      Autophagy

      Volume: 12(1) Issue: 1 Pages: 1-222

    • DOI

      10.1080/15548627.2015.1100356

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Prediction of periodontal inflammation via metabolic profiling of saliva2016

    • Author(s)
      Kuboniwa M*, Sakanaka A, Hashino E, Bamba T, Fukusaki E, Amano A
    • Journal Title

      Journal of Dental Research

      Volume: 95 Issue: 12 Pages: 1381-1386

    • DOI

      10.1177/0022034516661142

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 特別企画「新時代の歯周病を知る」2016

    • Author(s)
      天野敦雄
    • Journal Title

      日本歯科評論

      Volume: 76 Pages: 32-54

    • Related Report
      2016 Annual Research Report
  • [Journal Article] uidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)2016

    • Author(s)
      Klionsky DJ, Amano A, and 2498 others
    • Journal Title

      Autophagy

      Volume: 12 Pages: 1-222

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 歯周病予防の機能性食品:ユーカリ抽出物2016

    • Author(s)
      天野敦雄
    • Journal Title

      フレグランスジャーナル

      Volume: 44 Pages: 18-23

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Relationship Between Decayed Teeth and Metabolic Syndrome: Data From 4716 Middle-Aged Male Japanese Employees2015

    • Author(s)
      Ojima M, Amano A, Kurata S
    • Journal Title

      Journal of Epidemiology

      Volume: 25 Issue: 3 Pages: 204-211

    • DOI

      10.2188/jea.JE20140132

    • NAID

      130004851898

    • ISSN
      0917-5040, 1349-9092
    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Involvement of protease-activated receptor 4 in over-expression of matrix metalloproteinase 9 induced by Porphyromonas gingivalis.2015

    • Author(s)
      Hiroaki Inaba, Atsuo Amano, Richard J Lamont, Yukitaka Murakami
    • Journal Title

      Medical Microbiology and Immunology

      Volume: on line Issue: 5 Pages: 605-612

    • DOI

      10.1007/s00430-015-0389-y

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Arginine-ornithine antiporter ArcD in Streptococcus gordonii controls arginine metabolism and biofilm development with Fusobacterium nucleatum by ornithine cross-feeding.2015

    • Author(s)
      Sakanaka A, Kuboniwa M, Takeuchi H, Hashino E, Amano A
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 290 Issue: 35 Pages: 21185-21198

    • DOI

      10.1074/jbc.m115.644401

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Natural experiment for inferring causal qssociation between smoking and tooth loss: a study of a workplace contemporary cohort2015

    • Author(s)
      Hanioka T, Haresaku S, Suzuki N, Shimada K, Watanabe M, Ojima M, Fujiie K, Watanabe M
    • Journal Title

      International Journal of Statistics in Medical Research

      Volume: 4 Pages: 331-336

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antibacterial activity of curcumin against periodontopathic bacteria2015

    • Author(s)
      Izui S, Sekine S, Maeda K, Kuboniwa M, Takada A, Amano A, Nagata H
    • Journal Title

      Journal of Periodontology

      Volume: 87 Pages: 83-90

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Outer membrane vesicles - offensive weapons or good Samaritans?2015

    • Author(s)
      Olsen I, Amano A
    • Journal Title

      Journal of Oral Microbiology

      Volume: 7 Issue: 1 Pages: 27468-27468

    • DOI

      10.3402/jom.v7.27468

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 歯周病の発症と全身疾患:21世紀の新展開2015

    • Author(s)
      天野敦雄,竹内洋輝,久保庭雅恵
    • Journal Title

      日本臨床腸内微生物学会誌

      Volume: 17 Pages: 26-32

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
  • [Journal Article] 21世紀のペリオドントロジー ~最新病因論に基づいた診断・治療・生涯マネージメント~2015

    • Author(s)
      天野敦雄
    • Journal Title

      日本アンチエイジング歯科学会誌

      Volume: 8 Pages: 114-116

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 健口とアンチエイジング2015

    • Author(s)
      天野敦雄
    • Journal Title

      Food Style

      Volume: 19 Pages: 54-56

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Involvement of protease-activated receptor 4 in over-expression of matrix metalloproteinase 9 induced by Porphyromonas gingivalis2015

    • Author(s)
      Inaba H, Amano A, Lamont RJ, Murakami Y
    • Journal Title

      Medical Microbiology and Immunology

      Volume: -

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Proteomic and Transcriptional Analysis of Interaction between Oral Microbiota Porphyromonas gingivalis and Streptococcus oralis.2015

    • Author(s)
      Maeda K, Nagata H, Ojima M, Amano A
    • Journal Title

      Journal of Proteome Research

      Volume: 14 Issue: 1 Pages: 82-94

    • DOI

      10.1021/pr500848e

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Molecular identification and antibiotic-resistant bacteria isolated from primary dentition infections2014

    • Author(s)
      Loyola-Rodriguez JP, Garcia-Cortes JO, Martinez-Martinez RE, Patiño-Marin N, Martinez-Castañon GA, Zavala-Alonso NV, Amano A
    • Journal Title

      Australian Dental Journal

      Volume: 59 Issue: 4 Pages: 497-503

    • DOI

      10.1111/adj.12213

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Salivary inflammatory cytokines may be novel markers of carotid atherosclerosis in a Japanese general population: the Suita study.2014

    • Author(s)
      Kosaka T, Kokubo Y, Ono T, Sekine S, Kida M, Kikui M, Yamamoto M, Watanabe M, Amano A, Maeda Y, Miyamoto Y.
    • Journal Title

      Atherosclerosis.

      Volume: 237(1) Issue: 1 Pages: 123-8

    • DOI

      10.1016/j.atherosclerosis.2014.08.046

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Porphyromonas gingivalis promotes invasion of oral squamous cell carcinoma through induction of proMMP9 and its activation2014

    • Author(s)
      Inaba H, Sugita H, Kuboniwa M, Iwai S, Hamada M, Noda T, Morisaki I, Lamont RJ, Amano A
    • Journal Title

      Cellular Microbiology

      Volume: 16(1) Issue: 1 Pages: 131-145

    • DOI

      10.1111/cmi.12211

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic characteristics and pathogenic mechanisms of periodontal pathogens2014

    • Author(s)
      Amano A, Chen C, Honma K, Li C, Settem RP, Sharma A
    • Journal Title

      Advances in Dental Research

      Volume: 26(1) Issue: 1 Pages: 15-22

    • DOI

      10.1177/0022034514526237

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcellular invasive mechanisms of Porphyromonas gingivalis in host-parasite interactions.2014

    • Author(s)
      Amano A, Kuboniwa M, Takeuchi H
    • Journal Title

      Journal of Oral Biosciences

      Volume: 56 Issue: 2 Pages: 58-62

    • DOI

      10.1016/j.job.2014.02.001

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The periodontal pathogen Porphyromonas gingivalis exits from gingival epithelial cell via recycling pathways2014

    • Author(s)
      Takeuchi H, Amano A
    • Journal Title

      Journal of Osaka University Dental Society

      Volume: 59 Pages: 13-15

    • NAID

      120005602792

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 臨床指針・口腔衛生ケアステップ2014

    • Author(s)
      八重垣 健,秋房住郎,天野敦雄,薄井由枝,葭原明弘
    • Journal Title

      口腔衛生学会雑誌

      Volume: 64 Pages: 296-298

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 歯周疾患の疫学指標の問題点と課題2014

    • Author(s)
      森田 学,天野敦雄,伊藤博夫,齋藤俊行,佐藤 勉,廣瀬公治,山本龍生,川崎弘二
    • Journal Title

      口腔衛生学会雑誌

      Volume: 64 Pages: 299-304

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 口腔細菌と全身疾患:21世紀の新展開2014

    • Author(s)
      天野敦雄
    • Journal Title

      小児歯科臨床

      Volume: 19 Pages: 19-27

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 「健口」を考える:口からの健康~食べる・生きる・暮らす2014

    • Author(s)
      天野敦雄
    • Journal Title

      関西労健

      Volume: 85 Pages: 4-22

    • Related Report
      2014 Annual Research Report
  • [Presentation] 高病原性プラークと低病原性プラークを見分ける2018

    • Author(s)
      天野敦雄
    • Organizer
      第5回滋賀県歯科学術シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Involvement of Rab4A-relative factors in intracellular trafficking of Porphyromonas gingivalis in gingival epithelial cells2017

    • Author(s)
      Takeuchi H, Amano A
    • Organizer
      PG Melbourne 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Metabolic pathways involved in phenotypic alteration between planktonic and biofilm-forming stages in Porphyromonas2017

    • Author(s)
      Kuboniwa M, Sakanaka A, Amano A
    • Organizer
      PG Melbourne 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Microbial lifestyle in periodontal health and disease2017

    • Author(s)
      Amano A
    • Organizer
      Kyonpok University Friendship Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Butyrate production in Fusobacterium nucleatum is enhanced by cross-feeding with Streptococcus gordonii2017

    • Author(s)
      Sakanaka A, Kuboniwa M, Amano A
    • Organizer
      FEMS 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 教育講演 病原性の高いプラークと低いプラーク2017

    • Author(s)
      天野敦雄
    • Organizer
      日本臨床歯周病学会 第35回年次大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 鼻も喉も大切だが、口だって大切2017

    • Author(s)
      天野敦雄
    • Organizer
      第5回口腔病巣疾患研究会総会・学術大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 歯周感染論から見た予測歯科の可能性2017

    • Author(s)
      天野敦雄
    • Organizer
      第56回広島県歯科医学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] できる歯科衛生士はバイオフィルムの病原性を見分ける2017

    • Author(s)
      天野敦雄
    • Organizer
      第8回日本歯科衛生教育学会総会・学術大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Porphyromonas gingivalisの線毛遺伝子多型と歯周病原性2017

    • Author(s)
      天野敦雄
    • Organizer
      第60回日本歯周病学会総会・学術大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Porphyromonas gingivalisの増殖に伴う代謝変動の解析2017

    • Author(s)
      坂中哲人、久保庭雅恵、天野敦雄
    • Organizer
      第66回日本口腔衛生学会・総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 歯周病菌のメンブレンベジクルは歯周組織への弾丸2016

    • Author(s)
      天野敦雄,泉井 秀介
    • Organizer
      第89回日本細菌学会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Microbial dynamics in subgingival lifestyle2016

    • Author(s)
      Atsuo Amano
    • Organizer
      Current & Future Challenges in Dentistry: CGOH Joint symposium in Taiwan
    • Place of Presentation
      Taichung, Taiwan
    • Year and Date
      2016-03-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Microbial dynamics in subgingival lifestyle2016

    • Author(s)
      Atsuo Amano
    • Organizer
      Current & Future Challenges in Dentistry: CGOH Joint symposium in Taiwan
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2016-03-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Dual lifestyle of periodontal pathogen in biofilm and gingival cells2016

    • Author(s)
      Amano A
    • Organizer
      IADR/APR Symposium, 94th IADR General Meeting
    • Place of Presentation
      COEX Convention & Exhibition Center, Seoul, Korea
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 生涯メインテナンスの歯科医療2016

    • Author(s)
      天野敦雄
    • Organizer
      LDHシンポジウム
    • Place of Presentation
      東京都港区虎ノ門ヒルズフォーラム
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 歯周病因論から歯周治療を再考する2016

    • Author(s)
      天野敦雄
    • Organizer
      第68回近畿北陸地区歯科医学大会・シンポジウム
    • Place of Presentation
      大阪府大阪市大阪国際会議場
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 歯周病菌の歯周組織傷害戦略2016

    • Author(s)
      天野敦雄
    • Organizer
      第23回日本歯科医学会総会・シンポジウム
    • Place of Presentation
      福岡県福岡市福岡国際会議場
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Salivary microbially-derived metabolic signatures are linked to periodontal inflammatory status2016

    • Author(s)
      Sakanaka A, Kuboniwa M, Hashino E, Fukusaki E, Amano A
    • Organizer
      94th IADR General Meeting
    • Place of Presentation
      COEX Convention & Exhibition Center, Seoul, Korea
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Relationship between tongue coating and salivary metabolome2016

    • Author(s)
      Sakanaka A, Kuboniwa M, Hashino E, Amano A
    • Organizer
      12th International Conference of Asian Academy of Preventive Dentistry
    • Place of Presentation
      東京都千代田区東京医科歯科大学
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 歯周病菌の組織破壊戦略:変貌する歯周病因論2015

    • Author(s)
      天野敦雄
    • Organizer
      第24回日本口腔感染症学会学術大会
    • Place of Presentation
      鶴見大学会館(神奈川県横浜市)
    • Year and Date
      2015-11-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] New insight into molecular control of subgingival microbiome2015

    • Author(s)
      Masae Kuboniwa
    • Organizer
      Yonsei University College of Dentistry Centennial Memorial Symposium
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2015-11-06
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Microbial dynamics in subgingival lifestyle2015

    • Author(s)
      Atsuo Amano
    • Organizer
      63rd Annual Meeting of Japanese Association for Dental Research
    • Place of Presentation
      福岡国際会議場(Hakata, Fukuoka)
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 21世紀の科学で語るペリオドントロジ-2015

    • Author(s)
      天野敦雄
    • Organizer
      平成27年度福岡県歯科医学会
    • Place of Presentation
      福岡県歯科医師会館(福岡県福岡市)
    • Year and Date
      2015-09-06
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Attack system of periodontal pathogen2015

    • Author(s)
      Atsuo Amano
    • Organizer
      Ankara-Osaka University Faculty Dentistry Jopint Symposium “Recent Advancements in Dental Technology”
    • Place of Presentation
      Ankara, Turky
    • Year and Date
      2015-06-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Relationship between decayed teeth and metabolic syndrome: data from 4716 Japanese male employees ages 42 and 462015

    • Author(s)
      小島美樹
    • Organizer
      第64回日本口腔衛生学会総会
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 21世紀の科学のペリオドントロジ- 最新病因論に基づいた診断・治療・生涯マネージメント2015

    • Author(s)
      天野敦雄
    • Organizer
      日本アンチエイジング歯科学会10周年記念学術大会
    • Place of Presentation
      東京k国際フォーラム(東京都千代田区)
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Involvement of Rab4A and VAMP2 in intracellular Porphyromonas gingivalis in gingival epithelial cells2014

    • Author(s)
      Takeuchi H, Amano A
    • Organizer
      62nd Annual Meeting of Japanese Association for Dental Research
    • Place of Presentation
      KKRホテル大阪(大阪府大阪市)
    • Year and Date
      2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Relationship between periodontal condition and fatty liver in non-drinkers2014

    • Author(s)
      Ojima M, Amano A, Kurata S
    • Organizer
      62nd Annual Meeting of Japanese Association for Dental Research
    • Place of Presentation
      KKRホテル大阪(大阪府大阪市)
    • Year and Date
      2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Unique strategic system of Porphyromonas gingivalis in periodontitis2014

    • Author(s)
      Amano A
    • Organizer
      Osaka University - UCSF Joint Symposium “Current and Future Challenges in Oral Sciences”
    • Place of Presentation
      サンフランシスコ(アメリカ)
    • Year and Date
      2014-11-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] PotDがStreptococcus gordoniiの酸性環境中でのバイオフィルム形成に及ぼす影響2014

    • Author(s)
      坂中哲人、久保庭雅恵、竹内洋輝、橋野恵衣、天野敦雄
    • Organizer
      第25回近畿・中国・四国口腔衛生学会
    • Place of Presentation
      兵庫県歯科医師会館(兵庫県神戸市)
    • Year and Date
      2014-10-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 歯周病の発症と全身疾患:21世紀の新展開2014

    • Author(s)
      天野敦雄
    • Organizer
      第17回日本臨床腸内微生物学会総会・学術集会
    • Place of Presentation
      東京慈恵医大(東京都港区)
    • Year and Date
      2014-10-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Decayed teeth and metabolic syndrome in early middle-aged Japanese2014

    • Author(s)
      Ojima M, Amano A, Kurata S
    • Organizer
      11th International Conference of Asian Academy of Preventive Dentistr
    • Place of Presentation
      北京(中国)
    • Year and Date
      2014-09-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Inhibitory effect of curcumin on Porphyromonas gingivalis infection2014

    • Author(s)
      Izui, Amano A, Kurata S
    • Organizer
      11th International Conference of Asian Academy of Preventive Dentistr
    • Place of Presentation
      北京(中国)
    • Year and Date
      2014-09-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] A putative arginine-ornithine antiporter ArcD in Streptococcus gordonii controls de novo arginine biosynthesis, low pH tolerance and biofilm formation2014

    • Author(s)
      Sakanaka A, Kuboniwa M, Takeuchi H, Hashino E, Amano A
    • Organizer
      EMBO meeting
    • Place of Presentation
      パリ(フランス)
    • Year and Date
      2014-09-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Involvement of VAMP2 in intracellular localization of Porphyromonas gingivalis2014

    • Author(s)
      Takeuchi H, Takada A, Amano A
    • Organizer
      International Association for Dental Research General Session & Exhibition
    • Place of Presentation
      ケープタウン(南アフリカ)
    • Year and Date
      2014-06-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Involvement of VAMP2 in intracellular localization of Porphyromonas gingivalis in recycling endosomes2014

    • Author(s)
      Takeuchi H, Amano A
    • Organizer
      第56回 歯科基礎医学会学術大会・総会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2014-06-27
    • Related Report
      2014 Annual Research Report
  • [Book] 歯科臨床の羅針盤20172017

    • Author(s)
      天野敦雄
    • Total Pages
      200
    • Publisher
      インターアクション株式会社
    • Related Report
      2017 Annual Research Report
  • [Book] 病原菌の今日的意味(5版 松本慶蔵 編)2016

    • Author(s)
      天野敦雄
    • Total Pages
      798
    • Publisher
      医薬ジャーナル
    • Related Report
      2016 Annual Research Report
  • [Book] 病原菌の今日的意味2016

    • Author(s)
      天野敦雄 他
    • Total Pages
      500
    • Publisher
      医薬ジャーナル
    • Related Report
      2015 Annual Research Report
  • [Book] 歯科衛生士のための21世紀のペリオドントロジーダイジェスト2015

    • Author(s)
      天野敦雄
    • Total Pages
      101
    • Publisher
      クインテッセンス出版
    • Related Report
      2015 Annual Research Report
  • [Remarks] 大阪大学大学院歯学研究科予防歯科学教室

    • URL

      http://web.dent.osaka-u.ac.jp/~prevent/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 予防歯科学教室

    • URL

      http://web.dent.osaka-u.ac.jp/~prevent/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 大阪大学大学院歯学研究科

    • URL

      http://www.dent.osaka-u.ac.jp/

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-11-20   Modified: 2022-04-28  

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