Malaria elimination on the islands in Lake Victoria: mass drug administration with primaquine and the diversity of human and parasites

• Project/Area Number: 26257504
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Parasitology (including sanitary zoology)
• Research Institution: Osaka City University
• Principal Investigator: Kaneko Akira 大阪市立大学, 大学院医学研究科, 教授 (60169563)
• Co-Investigator(Kenkyū-buntansha): 五十棲 理恵 大阪市立大学, 大学院医学研究科, 講師 (30550355) ; 脇村 孝平 大阪市立大学, 大学院経済学研究科, 教授 (30230931) ; 皆川 昇 長崎大学, 熱帯医学研究所, 教授 (00363432) ; 平山 謙二 長崎大学, 熱帯医学研究所, 教授 (60189868) ; 金子 修 長崎大学, 熱帯医学研究所, 教授 (50325370) ; 平塚 真弘 東北大学, 薬学研究科, 准教授 (50282140)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥42,380,000 (Direct Cost: ¥32,600,000、Indirect Cost: ¥9,780,000); Fiscal Year 2017: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000); Fiscal Year 2016: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000); Fiscal Year 2015: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000); Fiscal Year 2014: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
• Keywords: マラリア / プリマキン / 集団投薬 / CYP2D6 / ケニア / 熱帯熱マラリア / G6PD欠損症 / マラリア撲滅 / CYP２D6 / アルテミシニン / 薬剤耐性

Outline of Final Research Achievements

Our malariometric survey throughout the granted period revealed the heterogeneity of malaria transmission in Lake Victoria basin. Furthermore most of the infection are asymptomatic and submicroscopic, supporting the importance of mass drug administration (MDA) and the strategy based on eco-epidemiological background. The MDA trial on Ngodhe Island showed that management of imported cases and strengthened vector control are necessary for sustainable malaria elimination in low transmission settings surrounded by middle to high transmission settings. This study provides the key information for malaria control program in sub-Saharan Africa where still suffer from high burden of malaria.

Research Products

• [Int'l Joint Research] カロリンスカ研究所(スウェーデン)
• [Int'l Joint Research] ケニア中央医学研究所（KEMRI)/ケニア保健省/マウントケニア大学(ケニア)
• [Int'l Joint Research] ヴァヌアツ保健省(バヌアツ)
• [Int'l Joint Research] カロリンスカ研究所(スウェーデン)
• [Int'l Joint Research] ケニア中央医学研究所（KEMRI）/ケニア保健省/マウントケニア大学(ケニア)
• [Int'l Joint Research] ヴァヌアツ保健省(バヌアツ)
• [Int'l Joint Research] Karolinska Institutet(スウェーデン)
• [Int'l Joint Research] Kenya Medical Research Institute (KEMRI)/Ministry of Health, Kenya/Mount Kenya University(ケニア)
• [Int'l Joint Research] Guangzhou University of Chinese Medicine(中国)
• [Int'l Joint Research] Ministry of Health, Vanuatu(バヌアツ)
• [Int'l Joint Research] LSHTM(英国)
• [Int'l Joint Research]
• [Journal Article] Improvement of malaria diagnostic system based on acridine orange staining (2018)
  • Author(s): Kimura Masatsugu、Teramoto Isao、Chan Chim W.、Idris Zulkarnain Md、Kongere James、Kagaya Wataru、Kawamoto Fumihiko、Asada Ryoko、Isozumi Rie、Kaneko Akira.
  • Journal Title: Malaria Journal Volume: 17 Issue: 1 Pages: 72-77
  • DOI: 10.1186/s12936-018-2214-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Rapid and sensitive multiplex single-tube nested PCR for the identification of five human Plasmodium species (2018)
  • Author(s): Saito Takahiro、Kikuchi Aoi、Kaneko Akira、Isozumi Rie、Teramoto Isao、Kimura Masatsugu、Hirasawa Noriyasu、Hiratsuka Masahiro
  • Journal Title: Parasitology International Volume: 67 Issue: 3 Pages: 277-283
  • DOI: 10.1016/j.parint.2018.01.005
  • Peer Reviewed / Open Access
• [Journal Article] Naturally acquired antibody response to Plasmodium falciparum describes heterogeneity in transmission on islands in Lake Victoria (2017)
  • Author(s): Idris Zulkarnain Md、Chan Chim W.、Kongere James、Hall Tom、Logedi John、Gitaka Jesse、Drakeley Chris、Kaneko Akira.
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 9123-9135
  • DOI: 10.1038/s41598-017-09585-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Serological measures to assess the efficacy of malaria control programme on Ambae Island, Vanuatu (2017)
  • Author(s): Idris Zulkarnain Md、Chan Chim W.、Mohammed Mubasher、Kalkoa Morris、Taleo George、Junker Klara、Arca Bruno、Drakeley Chris、Kaneko Akira.
  • Journal Title: Parasites & Vectors Volume: 10 Issue: 1 Pages: 204-215
  • DOI: 10.1186/s13071-017-2139-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group (2017)
  • Author(s): Thriemer Kamala、Kaneko Akira(49番目／67人中), et al.
  • Journal Title: Malaria Journal Volume: 16 Issue: 1 Pages: 141-149
  • DOI: 10.1186/s12936-017-1784-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Selections, frameshift mutations, and copy number variation detected on the surf 4.1 gene in the western Kenyan Plasmodium falciparum population. (2017)
  • Author(s): Gitaka JN, Takeda M, Kimura M, Idris ZM, Chan CW, Kongere J, Yahata K, Muregi FW, Ichinose Y, Kaneko A, Kaneko O
  • Journal Title: Malar Journal Volume: 16 Issue: 1 Pages: 98-109
  • DOI: 10.1186/s12936-017-1743-x
  • NAID: 120006987547
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Serological measures to access the efficacy of malaria control programme on Ambae Island, Vanuatu. (2017)
  • Author(s): Idris ZM, Chan CW, Mohammed M, Kalkoa M, Taleo G, Junker K, Arcà B, Drakeley C, Kaneko A.
  • Journal Title: Parasit Vectors Volume: 印刷中
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Secular change in adult stature associated with modernization in Vanuatu. (2017)
  • Author(s): Olszowy KM, Sun C, Silverman H, Pomer A, Dancause KN, Chan CW, Lee G, Tarivonda L, Reganvanu R, Kaneko A, Weitz C, Lum JK, Garruto RM.
  • Journal Title: Am J Hum Biol. Volume: 印刷中
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Challenges for achieving safe and effective radical cure of Plasmodium vivax - a round table discussion of the APMEN Vivax Working Group. (2017)
  • Author(s): Thriemer K, Kaneko A（49番目／67人中）, et al.
  • Journal Title: Malar J. Volume: 印刷中
  • Int'l Joint Research
• [Journal Article] Surveillance for malaria outbreak on malaria-eliminating islands in Tafea Province, Vanuatu after Tropical Cyclone Pam in 2015. (2017)
  • Author(s): Chan CW, Iata H, Yaviong J, Kalkoa M, Yamar S, Taleo G, Isozumi R, Fukui M, Aoyama F, Pomer A, Dancause KN, Kaneko A.
  • Journal Title: Epidemiol Infect. Volume: 145 Issue: 1 Pages: 41-45
  • DOI: 10.1017/s0950268816002041
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] High and heterogeneous prevalence of asymptomatic and sub-microscopic malaria infections on islands in Lake Victoria, Kenya. (2016)
  • Author(s): Idris ZM, Chan CW, Kongere J, Gitaka J, Logedi J, Omar A, Obonyo C, Machini BK, Isozumi R, Teramoto I, Kimura M, Kaneko A.
  • Journal Title: Sci Rep. Volume: 6 Issue: 1 Pages: 36958-36958
  • DOI: 10.1038/srep36958
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Genetic Diversity And Population Structure Of Plasmodium Falciparum In Lake Victoria Islands, A Region Of Intense Transmission (2016)
  • Author(s): Mulenge FM, Hunja CW, Magiri E, Culleton R, Kaneko A, Aman RA
  • Journal Title: American Journal of Tropical Medicine & Hygiene Volume: 95 Issue: 5 Pages: 1077-1085
  • DOI: 10.4269/ajtmh.16-0383
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 人類はマラリアを根絶できるか―島嶼からの挑戦― (2016)
  • Author(s): 加賀谷渉、金子明
  • Journal Title: 医学のあゆみ Volume: 259 Pages: 1229-1240
• [Journal Article] Little polymorphism at the K13 propeller locus in worldwide Plasmodium falciparum populations prior to the introduction of artemisinin combination therapies. (2016)
  • Author(s): Mita T, Culleton R, Takahashi N, Nakamura M, Tsukahara T, Hunja CW, Win ZZ, Htike WW, Marma AS, Dysoley L, Ndounga M, Dzodzomenyo M, Akhwale WS, Kobayashi J, Uemura H, Kaneko A, Hombhanje F, Ferreira MU, Björkman A, Endo H, Ohashi J.
  • Journal Title: Antimicrob Agents Chemother Volume: 印刷中
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A prescription for sustaining community engagement in malaria elimination on Aneityum Island, Vanuatu: an application of Health Empowerment Theory. (2015)
  • Author(s): Watanabe N, Kaneko A, Yamar S, Taleo G, Tanihata T, Lum JK, Larson PS. Shearer NBC.
  • Journal Title: Malar J. Volume: 14 Issue: 1 Pages: 291-291
  • DOI: 10.1186/s12936-015-0779-z
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Improved detection of malaria cases in island settings of Vanuatu and Kenya by PCR that targets the Plasmodium mitochondrial cytochrome c oxidase III (cox3) gene. (2015)
  • Author(s): Isozumi R, Fukui M, Kaneko A, Chan CW, Kawamoto F, Kimura M.
  • Journal Title: Parasitol Int. Volume: 64(3) Issue: 3 Pages: 304-8
  • DOI: 10.1016/j.parint.2014.09.006
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Plasmodium vivax gametocyte proteins, Pvs48/45 and Pvs47, induce transmission-reducing antibodies by DNA immunization (2015)
  • Author(s): Tachibana M, Suwanabun N, Kaneko O, Iriko H, Otsuki H, Sattabongkot J, Kaneko A, Herrera S, Torii M, Tsuboi T
  • Journal Title: Vaccine Volume: 33 Issue: 16 Pages: 1901-1908
  • DOI: 10.1016/j.vaccine.2015.03.008
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Novel Mutations in K13 Propeller Gene of Artemisinin-Resistant Plasmpdium falciparum. (2015)
  • Author(s): Isozumi R, Uemura H, Kimata I, Ichinose Y, Logedi J, Omar AH, Kaneko A.
  • Journal Title: Emerg Infect Dis Volume: 21(3) Issue: 3 Pages: 490-2
  • DOI: 10.3201/eid2103.140898
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Plasmodium vivax and Plasmodium falciparum at the Crossroads of Exchange among Islands in Vanuatu: Implications for Malaria Elimination Strategies. (2015)
  • Author(s): Chan CW, Sakihama N, Tachibana S, Lum JK, Tanabe K, Kaneko A.
  • Journal Title: PloS One Volume: 10(3) Issue: 3 Pages: e0119475-e0119475
  • DOI: 10.1371/journal.pone.0119475
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Determinants of the use of insecticide-treated bed nets on islands of pre- and post-malaria elimination: an application of the health belief model in Vanuatu. (2014)
  • Author(s): Watanabe N, Kaneko A, Yamar S, Leodoro H, Taleo G, Tanihata T, Lum JK, Larson PS.
  • Journal Title: Malaria Journal Volume: 13 Issue: 1 Pages: 441-441
  • DOI: 10.1186/1475-2875-13-441
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Single nucleotide polymorphisms in Plasmodium falciparum V type H+ pyrophosphatase gene (pfvp2) and their associations with pfcrt and pfmdr1 polymorphisms. (2014)
  • Author(s): JovelIT, Ferreira PE, Veiga MI, Malmberg M, Mårtensson A, Kaneko A, Zakeri S, Murillo C, Nosten F, Björkman A, Ursing J.
  • Journal Title: Infect Genet Evol. Volume: in press Pages: 111-5
  • DOI: 10.1016/j.meegid.2014.03.004
  • Peer Reviewed / Open Access
• [Presentation] Age-dependently acquired antibody response to Plasmodium falciparum describes transmission heterogeneity in the Lake Victoria basin, Kenya. (2018)
  • Author(s): Akira Kaneko、Zulkarnain Md Idris、Chim W. Chan、James Kongere、Tom Hall、Jesse Gitaka、Chris Drakeley.
  • Organizer: 第87回日本寄生虫学会大会
• [Presentation] 不均一なマラリア流行地におけるマラリア感染流入に関わる危険集団の同定 (2018)
  • Author(s): 加賀谷渉、Chim Chan、宇都宮剛、Jesse Gitaka、James Kongere、金子明.
  • Organizer: 第87回日本寄生虫学会大会
• [Presentation] Overview of Africa Taskforce (2018)
  • Author(s): 金子 明
  • Organizer: 日経アジア感染症会議
  • Int'l Joint Research / Invited
• [Presentation] The impact of mass drug administration on submicroscopic malaria infection: A pilot study on Ngodhe island in Lake Victoria, Kenya. (2017)
  • Author(s): Wataru Kagaya、Chim Chan、Jesse Gitaka、James Kongere、Zulkarnain Md Idris、Changsheng Deng、Guoqiao Li、Lucy Okell、Akira Kaneko.
  • Organizer: The ASTMH 66th Annual Meeting
  • Int'l Joint Research
• [Presentation] Naturally acquired antibody response to Plasmodium falciparum describes heterogeneity in transmission on islands in Lake Victoria. (2017)
  • Author(s): Akira Kaneko、Zulkarnain Md Idris、Chim W. Chan、James Kongere、Tom Hall、John Logedi、Jesse Gitaka、Chris Drakeley.
  • Organizer: The ASTMH 66th Annual Meeting
  • Int'l Joint Research
• [Presentation] ケニア・ヴィクトリア湖周辺地域におけるマラリア対策戦略の開発 (2017)
  • Author(s): 加賀谷渉、Chim Chan、Zulkarnain Md Idris、James Kongere、Jesse Gitaka、皆川昇、Lucy Okell、一瀬休生、金子明.
  • Organizer: 海外学術調査フォーラム
• [Presentation] Mass drug administration to eliminate malaria on islands. (2017)
  • Author(s): Kaneko A
  • Organizer: U.S.-Japan Cooperative Medical Sciences Program (USJCMSP), 19th International Conference on Emerging Infectious Diseases (EID) in the Pacific Rim
  • Int'l Joint Research / Invited
• [Presentation] LED光源を用いた、改良AO 染色法によるマラリア迅速診断 (2016)
  • Author(s): 木村 政継、寺本 勲、チムＷ チャン、川本 文彦、朝田 良子、金子 明
  • Organizer: 第85回日本寄生虫学会大会
  • Place of Presentation: 宮崎市民プラザ（宮崎県宮崎市）
  • Year and Date: 2016-03-20
• [Presentation] Mass Drug administration targets high prevalence of asymptomatic and submicroscopic malaria infections in the Lake Victoria region of Kenya. (2016)
  • Author(s): 金子 明、Md Idris Zulkarnain、Chan Chim W, 五十棲 理恵, 寺本 勲, 木村 政継
  • Organizer: 第85回日本寄生虫学会大会
  • Place of Presentation: 宮崎市民プラザ（宮崎県宮崎市）
  • Year and Date: 2016-03-20
• [Presentation] マラリアを根絶できるか －島嶼からの挑戦― (2016)
  • Author(s): 金子明
  • Organizer: 第57回日本熱帯医学会大会
  • Invited
• [Presentation] ケニア・ビクトリア湖島嶼における高度かつ不均一な無症候性マラリア感染率-撲滅戦略構築への意味合い (2016)
  • Author(s): 金子明
  • Organizer: 第72 回日本寄生虫学会西日本支部大会
• [Presentation] Sustainability of malaria elimination on Aneityum island, Vanuatu, 1991 - 2015. (2016)
  • Author(s): Kaneko A
  • Organizer: RSTMH Biennial Meeting - Challenges in Disease Elimination
  • Int'l Joint Research
• [Presentation] Mass drug administration to eliminate malaria on Ngodhe Island in Lake Victoria, Kanya: a pilot study. (2016)
  • Author(s): Kagaya W
  • Organizer: RSTMH Biennial Meeting - Challenges in Disease Elimination
  • Int'l Joint Research
• [Presentation] 熱帯アフリカのマラリア根絶は可能か－集団投薬の役割 (2015)
  • Author(s): 金子 明
  • Organizer: 第56回日本熱帯医学会大会
  • Place of Presentation: 大阪大学コンベンションセンター（大阪府吹田市）
  • Year and Date: 2015-12-05
• [Presentation] Sustainable malaria elimination on Aneityum Island, Vanuatu, 1991-2014. (2015)
  • Author(s): Kaneko Akira
  • Organizer: The Third Nordic Malaria Conference
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2015-10-08
  • Int'l Joint Research
• [Presentation] MDA for malaria elimination in Aneityum Island, Vanuatu. (2015)
  • Author(s): Kaneko Akira
  • Organizer: WHO Evidence Review Group on Mass Drug Administration(MDA), Mass Screening and Treatment(MSAT) and Focused Screening and Treatment(FSAT)
  • Place of Presentation: Geneva, Switzerland
  • Year and Date: 2015-04-21
  • Int'l Joint Research
• [Presentation] Sustainable malaria elimination on Aneityum Island, Vanuatu, 1991 -2014. (2014)
  • Author(s): Kaneko A.
  • Organizer: American Society of Tropical Medicine and Hygiene 63rd Annual Meeting
  • Place of Presentation: New Orleans(USA)
  • Year and Date: 2014-11-02 – 2014-11-06
• [Funded Workshop] Workshop for malaria elimination and community engagement. Mbita, Kenya (2018)
• [Funded Workshop] Workshop for malaria elimination and community engagement (2016)
  • Place of Presentation: Mbita, Kenya
  • Year and Date: 2016-02-03