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Studies to search for the process from the birth of AIDS virus in the heart of African continent to its pandemic transmission route to the whole world

Research Project

Project/Area Number 26257505
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Virology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

IDO Eiji  東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 (70183176)

Co-Investigator(Kenkyū-buntansha) 伊吹 謙太郎  京都大学, 医学研究科, 准教授 (00273524)
亀岡 正典  神戸大学, 保健学研究科, 准教授 (60281838)
中村 昇太  大阪大学, 微生物病研究所, 特任准教授(常勤) (90432434)
Research Collaborator Muyembe Jean Jacques  国立生物医学研究所, 所長
Ahuka Steve  キンシャサ大学, 医学部, 助教授
Parra Henri Joseph  国立公衆衛生研究所, 所長
Taty Raphael Taty  ポイントノアール感染症診療所, 所長
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
Fiscal Year 2017: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2016: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2015: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2014: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Keywordsウイルス / 感染症 / エイズ / 進化 / アフリカ / HIV / コンゴ盆地
Outline of Final Research Achievements

Concerning the origin of HIV, it is generally believed that the virus might have been generated somewhere in the central part of African continent because its current genetic diversity is the highest there. We attempted to elucidate its birth place and the transmission route how the subsequent AIDS pandemic occurred to the whole world by visiting several places in the Congo basin and examining the distribution profiles of the viral genotypes historically and molecular epidemiologically. The respective districts showed their own regional specific patterns, and we finally clarified that the most spreaded subtype B(D) in the developed countries can be still existing in eastern part of Democratic Republic of Congo. We also investigated into the HIV drug resistances and found that the invasion of drug resistant mutations is unexpectedly limited in the Congo basin but that the viral genome is even now dynamically changing by recombination as well as vigorous mutations.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (45 results)

All 2018 2017 2016 2015 2014 Other

All Int'l Joint Research (7 results) Journal Article (15 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 15 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (23 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Int'l Joint Research] 国立生物医学研究所/キンシャサ大学(コンゴ民主共和国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] ポアント・ノアール感染症診療所/国立公衆衛生研究所(コンゴ共和国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] アイルランガ大学(インドネシア)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] 国立生物医学研究所/キンシャサ大学(コンゴ民主共和国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] 国立公衆衛生研究所/ポアント・ノアール感染症診療所(コンゴ共和国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] 国立生物医学研究所/キンシャサ大学(コンゴ民主共和国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] 国立公衆衛生研究所(コンゴ共和国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Genotypic characterization of HIV-1 prevalent in Kepulauan Riau, Indonesia.2018

    • Author(s)
      Khairunisa, S. Q., Ueda, S., Witaningrum, A. M., Yunifiar M., M. Q., Indriati, D. W., Kotaki, T., Nasronudin, Kameoka, M.
    • Journal Title

      AIDS Res. Hum. Retroviruses

      Volume: 印刷中 Issue: 6 Pages: 555-560

    • DOI

      10.1089/aid.2018.0040

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Genotypic characterization of human immunodeficiency virus type 1 isolated in Bali, Indonesia in 2016.2018

    • Author(s)
      Khairunisa, S. Q., Masyeni, S., Witaningrum, A. M., Yunifiar M., M. Q., Indriati, D. W., Kotaki, T., Ueda, S., Budiyasa, D. G., Nasronudin, Kameoka, M.
    • Journal Title

      HIV AIDS Rev.

      Volume: 印刷中

    • NAID

      120006489893

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] アフリカ大陸における蚊媒介性ウイルス感染症2018

    • Author(s)
      井戸栄治
    • Journal Title

      別冊BIO Clinica

      Volume: 6(2) Pages: 128-133

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A 2-4-amino acid deletion in the V5 Region of HIV-1 Env gp120 confers viral resistance to the broadly neutralizing human monoclonal antibody, VRC01.2017

    • Author(s)
      Tachibana, S., Sasaki, M., Tanaka, T., Inoue, M., Ophinni. Y., Kotaki, T., Kameoka, M.
    • Journal Title

      AIDS Res. Hum. Retroviruses

      Volume: 33(12) Issue: 12 Pages: 1248-1257

    • DOI

      10.1089/aid.2017.0063

    • NAID

      120006425711

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Genotypic Characterization of Human Immunodeficiency Virus Type 1 Derived from Antiretroviral Drug-Treated Individuals Residing in Earthquake-Affected Areas in Nepal2017

    • Author(s)
      Negi Bharat Singh、Kotaki Tomohiro、Joshi Sunil Kumar、Bastola Anup、Nakazawa Minato、Kameoka Masanori
    • Journal Title

      AIDS Research and Human Retroviruses

      Volume: 33 Issue: 9 Pages: 960-965

    • DOI

      10.1089/aid.2017.0047

    • NAID

      120006425710

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Genome-Wide Screening Uncovers the Significance of N-sulfation of Heparan Sulfate as a Host Cell Factor for Chikungunya Virus Infection2017

    • Author(s)
      Tanaka, A. Tumkosit, U. Nakamura, S. Motooka, D. Kishishita, N. Priengprom, T. Sa-Ngasang, A. Kinoshita, T. Takeda, N. Maeda, Y.
    • Journal Title

      Journal of virology

      Volume: Volume 91(13) Issue: 13

    • DOI

      10.1128/jvi.00432-17

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation of novel protease inhibitors against darunavir-resistant variants of human immunodeficiency virus type 1.2017

    • Author(s)
      Inoue, M., Oyama, D., Hidaka, K., Kameoka, M.
    • Journal Title

      FEBS Open Bio

      Volume: 7 Issue: 1 Pages: 88-95

    • DOI

      10.1002/2211-5463.12160

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Neutralization breadth and potency of serum derived from recently human immunodeficiency virus type 1-infected Thai individuals.2016

    • Author(s)
      Chaitaveep, N., Utachee, P., Chuenchitra, T., Karasavvan, N., Takeda, N., Kameoka, M.
    • Journal Title

      Microbes Infect.

      Volume: 18 Issue: 5 Pages: 346-353

    • DOI

      10.1016/j.micinf.2015.12.009

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Genotypic characterization of human immunodeficiency virus type 1 derived from antiretroviral therapy-naïve individuals residing in Sorong, West Papua.2016

    • Author(s)
      Witaningrum, A.M., Kotaki, T., Khairunisa, S.Q., Yunifiar M.M.Q., Indriati, D. W., Bramanthi, R., Nasronudin., Kameoka, M.
    • Journal Title

      AIDS Res. Hum. Retroviruses

      Volume: 32 Issue: 8 Pages: 812-817

    • DOI

      10.1089/aid.2016.0054

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Sensitivity of next-generation sequencing metagenomic analysis for detection of RNA and DNA viruses in cerebrospinal fluid: the confounding effect of background contamination.2016

    • Author(s)
      Bukowska-Osko, I., Perlejewski, K., Nakamura, S., Motooka, D., Stokowy, T., Kosinska, J., Popiel, M., Ploski, R., Horban, A., Lipowski, D., Caraballo Cortes, K., Pawelczyk, A., Demkow, U., Stepien, A., Radkowski, M., Laskus, T.
    • Journal Title

      Adv. Exp. Med. Biol.

      Volume: 944 Pages: 53-62

    • DOI

      10.1007/5584_2016_42

    • ISBN
      9783319444871, 9783319444888
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Next-generation sequencing (NGS) in the identification of encephalitis-causing viruses: Unexpected detection of human herpesvirus 1 while searching for RNA pathogens.2015

    • Author(s)
      Perlejewski K, Popiel M, Laskus T, Nakamura S, Motooka D, Stokowy T, Lipowski D, Pollak A, Lechowicz U, Caraballo CK, Stepien A, Radkowski M, Bukowska-Oska I.
    • Journal Title

      J. Virol. Methods

      Volume: 226 Pages: 1-6

    • DOI

      10.1016/j.jviromet.2015.09.010

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Appearance of drug resistance-associated mutations in human immunodeficiency virus type 1 protease and reverse transcriptase derived from drug-treated Indonesian patients.2015

    • Author(s)
      Khairunisa SQ, Kotaki T, Witaningrum AM, Yunifiar MMQ, Sukartiningrum SD, Nasronudin, Kameoka M.
    • Journal Title

      AIDS Res Hum Retroviruses

      Volume: 31(2) Issue: 2 Pages: 255-259

    • DOI

      10.1089/aid.2014.0221

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Joint research project on infectious diseases in West-African subregion.2014

    • Author(s)
      Ido E, Suzuki T, Ampofo WK, Ayi I, Yamaoka S, Koram KA, Ohta N.
    • Journal Title

      J Disaster Res

      Volume: 9 Pages: 813-817

    • NAID

      130007673773

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of amino acid substitutions in the V2 and C2 regions of human immunodeficienty virus type 1 CRF01_AE envelope glycoprotein gp120 onn viral neutralization susceptibility to broadly neutralizing antibodies specific for the CD4 binding site.2014

    • Author(s)
      Utachee P, Israngkura-Na-Ayuthaya P, Tokunaga K, Ikuta K, Takeda N, Kameoka M.
    • Journal Title

      Retrovirology

      Volume: 11 Issue: 1 Pages: 32-32

    • DOI

      10.1186/1742-4690-11-32

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of human immunodeficiency virus type 1 CRF01_AE env genes derived from recently infected Thai individuals.2014

    • Author(s)
      Chaitaveep N, Utachee P, Nakamura S, Chuenchitra T, Ekpo P, Takeda N, Pattanapanyasat K, Kameoka M.
    • Journal Title

      Microbes Infect

      Volume: 16 Pages: 142-152

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] Drug resistance analysis of PLWHIV under ART in Kongo Central Province, western Democratic Republic of Congo.2017

    • Author(s)
      Eiji Ido, Steve Ahuka, Stomy Karhemere, Keya Sumbu, Kentarou Ibuki, Jean-Jacques Muyembe.
    • Organizer
      International Conference on AIDS and STIs in Africa (ICASA2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Drug resistance analysis of PLWHIV under ART in Pointe-Noire, a coastal city in Republic of Congo.2017

    • Author(s)
      Ido, E., Ibuki, K., Taty Taty, R.
    • Organizer
      グローバルヘルス合同大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] コンゴ共和国西部の街ポアント・ノアール市で流行しているHIV遺伝子型の変遷.2017

    • Author(s)
      井戸栄治, Raphael Taty Taty, Steve Ahuka, 伊吹謙太郎, Jean-Jacques Muyembe
    • Organizer
      第31回日本エイズ学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Molecular epidemiology of HTLV among PLWHIV in the far western part of the Congo basin.2017

    • Author(s)
      Ido, E., Taty Taty, R., Ahuka Mundeke, S., Karhemere, S., Sumbu, K., Ibuki, K., Muyembe, J.J.
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] CRISPR/Cas9 system targeting HIV-1 regulatory genes tat and rev inhibits viral replication in persistently- and latently-infected T cells.2017

    • Author(s)
      Youdiil Ophinni, Mari Inoue, Masanori Kameoka
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Genotypic characterization of human immunodeficiency virus type 1 derived from infected individuals residing in Bali, Indonesia.2017

    • Author(s)
      Siti Qamariyah Khairunisa, Sri Masyeni, Adiana Mutamsari Witaningrum, Muhammad Qushai Yunifiar M., Dwi Wahyu Indriati, Tomohiro Kotaki, Shuhei Ueda, Dewa G Budiyasa, AAA Candrawati, Nasronudin, Masanori Kameoka
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Appearance of drug resistance-associated mutations in human immunodeficiency virus type 1 protease and reverse transcriptase derived from infected individuals in Papua, Indonesia.2017

    • Author(s)
      Adiana Mutamsari Witaningrum, Tomohiro Kotaki, Muhammad Qushai Yunifiar M., Siti Qamariyah Khairunisa, Dwi Wahyu Indriati, Shuhei Ueda, Nasronudin, Masanori Kameoka
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Nearly full-length sequencing of HIV-1 subtype B in Indonesia.2017

    • Author(s)
      Shuhei Ueda, Tomohiro Kotaki, Siti Qamariyah Kairusia, Adiana Mutamsari Witaningrum, Dwi Wahyu Indriati, Muhammad Qushai Yunifiar M., Nasronudin, Masanori Kameoka
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Characterization of HIV-1 env genes derived from recently infected Indonesian individuals.2017

    • Author(s)
      Maho Sasaki, Tomohiro Kotaki, Siti Qamariyah Kairusia, Nasronudin, Singo Tachibana, Youdiil Ophinni, Masanori Kameoka.
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高温条件下での樹状細胞におけるSIV感染機序の検討.2017

    • Author(s)
      國光健, 伊吹謙太郎.
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 免疫不全ウイルス感染病態研究におけるサル化マウスの有用性の検討.2017

    • Author(s)
      陣野萌恵, 関根 将, 横山温香, 三浦智行, 伊吹謙太郎.
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] コンゴ民主共和国西部バ・コンゴ州におけるART治療中エイズ患者のHIV薬剤耐性変異解析.2016

    • Author(s)
      井戸栄治, Ahuka, S., Karhemere, S., Sumbu, K., 伊吹謙太郎, Muyembe, J.J.
    • Organizer
      第31回国際保健医療学会
    • Place of Presentation
      久留米シティプラザ(福岡県・久留米市)
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] コンゴ民主共和国西部バ・コンゴ州における初のHIV分子疫学調査.2016

    • Author(s)
      井戸栄治, Ahuka, S., Karhemere, S., Sumbu, K., 伊吹謙太郎, Muyembe, J.J.
    • Organizer
      第30回日本エイズ学会学術集会・総会
    • Place of Presentation
      かごしま県民交流センター(鹿児島県・鹿児島市)
    • Year and Date
      2016-11-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] Identification of amino acid position in gp120 determining the neutralization.2016

    • Author(s)
      Tachibana, S., Tanaka, T., Inoue, M., Ophinni, Y., Kameoka, M.
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Joint Research Projects on Infectious Diseases by Tokyo Medical and Dental University in West and Central Africa.2016

    • Author(s)
      Ido E
    • Organizer
      1st International Symposium of the Pan-African NTDs and Infectious Disease Surveillance Network
    • Place of Presentation
      Nairobi(KENYA)
    • Year and Date
      2016-01-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Molecular epidemiology of HIV in North Kivu Province, Democratic Republic of Congo.2015

    • Author(s)
      Ido E, Karhemere S, Kayumba J, Mukedi J-M, Ahuka S, Aziati I, Agbosu E, Brandful J, Ibuki K, Muyembe JJ
    • Organizer
      第29回日本エイズ学会総会・学術集会
    • Place of Presentation
      東京ドームホテル(東京都・文京区)
    • Year and Date
      2015-11-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] Low frequency of drug-resistant mutations against HIV protease inhibitors among patients receiving the first-line ART in Republic of Ghana.2015

    • Author(s)
      Ido E, Barnor J, Aziati I, Agbosu E, Brandful J, Ampofo W, Ofori S, Danquah-Damptey G, Morton S, Yamaoka S
    • Organizer
      第29回日本エイズ学会総会・学術集会
    • Place of Presentation
      東京ドームホテル(東京都・文京区)
    • Year and Date
      2015-11-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] コンゴ盆地最奥地に位置するコンゴ民主共和国赤道州北部におけるHIVの分子疫学2014

    • Author(s)
      井戸栄治、Steve Ahuka、Stomy Karhemere、Bienvenue Mangonza、Ishmael Aziati、Jean-Jacques Muyembe
    • Organizer
      第28回日本エイズ学会学術集会・総会
    • Place of Presentation
      大阪(大阪国際会議場)
    • Year and Date
      2014-12-03 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] ガーナ共和国におけるHIV-2感染の実態調査に関する研究2014

    • Author(s)
      井戸栄治, Jacob Barnor, Ishmael Aziati, Esinam Agbosu, James Brandful, William Ampofo, Samson Ofori, 山岡昇司
    • Organizer
      第28回日本エイズ学会学術集会・総会
    • Place of Presentation
      大阪(大阪国際会議場)
    • Year and Date
      2014-12-03 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] インドネシア・スラバヤ市の性産業従事者におけるHIV流行2014

    • Author(s)
      亀岡正典、小瀧将裕、Siti Qamariyah Khairunisa、Septhia Dwi Sukartiningrum、M. Vitanata Arfijanto、内海孝子、Irine Normalina、Retno Handajani、Prihartini Widiyanti、Musofa Rusli、Retno Pudji Rahayu、Maria Inge Lusida、林 祥剛、Nasronudin
    • Organizer
      第28回日本エイズ学会学術集会・総会
    • Place of Presentation
      大阪(大阪国際会議場)
    • Year and Date
      2014-12-03 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 東南アジアで流行するHIVの特徴2014

    • Author(s)
      亀岡正典
    • Organizer
      第28回日本エイズ学会学術集会・総会
    • Place of Presentation
      大阪(大阪国際会議場)
    • Year and Date
      2014-12-03 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] インドネシアの薬剤未治療HIV-1患者における薬剤耐性変異の解析2014

    • Author(s)
      小瀧将裕、Siti Qamariyah Khairunisa、Adiana Mutamsari Witaningrum、Muhammad Qushai Yunifiar M、Septhia Dwi Sukartiningrum、M. Noor Diansyah、Retno Pudji Rahayu、Nasronudin、亀岡正典
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜(パシフィコ横浜国際会議場)
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 次世代シークエンスの過去・現在・未来〜ウィルス研究に与えるインパクト.2014

    • Author(s)
      中村 昇太
    • Organizer
      第62回 日本ウィルス学会学術集会
    • Place of Presentation
      横浜(パシフィコ横浜国際会議場)
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2019-03-29  

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