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High sensitive bio-fluorometric gas sensors using NADH-dependent enzymes catalyzing odorous chemicals

Research Project

Project/Area Number 26280053
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Perceptual information processing
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Mitsubayashi Kohji  東京医科歯科大学, 生体材料工学研究所, 教授 (40307236)

Co-Investigator(Kenkyū-buntansha) 當麻 浩司  東京医科歯科大学, 生体材料工学研究所, 助教 (40732269)
荒川 貴博  東京医科歯科大学, 生体材料工学研究所, 講師 (50409637)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywords生化学式蛍光ガスセンサ / NADH / 脱水素酵素 / 還元酵素 / 光計測 / センシングデバイス・システム
Outline of Final Research Achievements

Several biochemical gas sensors were developed using an NADH fluorometric unit with a UV-LED excitation and several dehydrogenase enzymes for high sensitive detection of odorous chemicals. As the results, the sensors allowed to monitor the concentration of volatile chemicals (nonenal by ALDH, acetaldehyde by ADH and formaldehyde by FALDH, respectively), thus showing the possibility of novel artificial nose.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (6 results)

All 2016 2015 2014

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results,  Open Access: 1 results) Presentation (4 results) (of which Invited: 1 results)

  • [Journal Article] Optical isopropanol biosensor using NADH-dependent secondary alcohol dehydrogenase (S-ADH)2016

    • Author(s)
      Po-Jen Chien, Ming Ye, Takuma Suzuki, Koji Toma, Takahiro Arakawa, Yasuhiko Iwasaki, Kohji Mitsubayashi
    • Journal Title

      Talanta

      Volume: 159 Pages: 418-424

    • DOI

      10.1016/j.talanta.2016.06.036

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A Fluorometric Biochemical Gas Sensor (Biosniffer) for Acetaldehyde Vapor Based on Catalytic Reaction of Aldehyde Dehydrogenase2015

    • Author(s)
      Y. Suzuki, M. Ye, K. Miyajima, T. Arakawa, S. Sawada, H. Kudo, K. Akiyoshi, K. Mitsubayashi
    • Journal Title

      Sensors and Materials

      Volume: 27(11) Pages: 1123-1130

    • DOI

      10.18494/SAM.2015.1149

    • ISSN
      0914-4935, 2435-0869
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 日常医療のためのキャビタス(体腔)センサと生体ガスのバイオ計測(光スニファ&探嗅カメラ)2016

    • Author(s)
      三林浩二
    • Organizer
      応用物理学会 有機分子・バイオエレクトロニクス分科会講習会
    • Place of Presentation
      東京理科大学 森戸記念館(飯田橋)
    • Year and Date
      2016-11-07
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ホルムアルデヒド用バイオスニファ(生化学式ガスセンサ)と環境浄化評価への応用2015

    • Author(s)
      簡 伯任、叶 明、當麻浩司、荒川貴博、工藤寛之、三林浩二
    • Organizer
      第47回化学工学会秋季大会
    • Place of Presentation
      北海道大学(北海道・札幌市)
    • Year and Date
      2015-09-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 加齢臭成分trans-2-ノネナールの気相バイオセンシングに関する研究2015

    • Author(s)
      森 英久,叶 明,當麻 浩司,荒川 貴博,三林 浩二
    • Organizer
      平成27年電気学会全国大会
    • Place of Presentation
      東京(東京都市大学)
    • Year and Date
      2015-03-24 – 2015-03-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Highly sensitive fiber-optic formaldehyde gas sensor (biosniffer) for food-sample detection2014

    • Author(s)
      Jen Chien P, Miyajima K, Munkhjargal M, Toma K, Arakawa T, Kudo H, Mitsubayashi K
    • Organizer
      International Conference on BioSensors, BioElectronics, BioMedical Devices, BioMEMS/NEMS and Applications (Bio4Apps) 2014
    • Place of Presentation
      Shanghai, China
    • Year and Date
      2014-11-17 – 2014-11-19
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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