Elucidation of neural mechanism for visual hallucinations of dementia with Lewy bodies with mathematical modelling
| Project/Area Number |
26280093
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Soft computing
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| Research Institution | Hokkaido University |
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Principal Investigator |
Tsuda Ichiro 北海道大学, 理学(系)研究科(研究院), 教授 (10207384)
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| Co-Investigator(Kenkyū-buntansha) |
合原 一幸 東京大学, 生産技術研究所, 教授 (40167218)
奈良 重俊 岡山大学, 自然科学研究科, 特命教授 (60231495)
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| Research Collaborator |
FUJII Hiroshi
KATORI Yuichi
COLLERTON Daniel
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Keywords | 視覚性幻覚 / アセチルコリン / レビー小体型認知症 / 注意機構 / カオス的遍歴 / ホドロジー / 幻覚 / 数理モデル / カオス力学系 / 神経回路モデル / 神経回路網モデル |
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| Outline of Final Research Achievements |
Elucidation of the neural mechanism for dementia with Lewy body (DLB) is an urgent issue in our society since the number of such patients is rapidly increasing. A typical characteristic of DLB is the appearance of complex visual hallucinations (CVH): Patients can see what are not there, and those hallucinations appear at only a partial location of a whole visual scene. In the present study, we investigated a neural mechanism of CVH that DLB patients can see, making a mathematical model of neural networks for CVH. Our neural network model yielded a hallucinatory behavior. Indeed, when we reduced drastically the number of local nicotinic receptors after a correct learning of each pair of index and object patterns, incorrect object patterns were locally produced for inputs of index patterns indicating correct contextual information. This computer experiment suggests that nicotinic receptors provide one of the neural mechanisms of CVH that DLB patients experience.
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Report
(4 results)
Research Products
(51 results)
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[Journal Article] How can we see things that are not there?2016
Author(s)
Daniel Collerton, John-Paul Taylor, Ichiro Tsuda, Hiroshi Fujii, Shigetoshi Nara, Kazuyuki Aihara, Yuichi Katori
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Journal Title
Journal of Consciousnes Studies
Volume: 23
Pages: 195-227
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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