Dynamical self-assembly and autonomous motion of cell-size molecular robots by the control of micrometer-scale nonequilibrium field
| Project/Area Number |
26280097
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Intelligent robotics
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
尾上 弘晃 慶應義塾大学, 理工学部(矢上), 准教授 (30548681)
原 雄介 国立研究開発法人産業技術総合研究所, 材料・化学領域, 研究グループ長 (90452135)
森田 雅宗 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究員 (90708504)
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| Co-Investigator(Renkei-kenkyūsha) |
NAGAI Ken 北陸先端科学技術大学院大学, 先端科学技術研究科, 助教 (40518932)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2016: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | 分子ロボット / 人工細胞 / DNAナノテクノロジー / マイクロマシン / 非平衡 / 自己組織化 / ゲル / エマルション / 動的自己組織化 / DNA |
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| Outline of Final Research Achievements |
In this study, we constructed methods to produce and control dynamical cell-sized molecular robots by the control of micrometer-scale nonequilibrium fields and spatiotemporal assembly of molecules. As a result of this study, we developed methods to produce asymmetric complex-shaped gel microparticles and a method to dynamically assemble the microparticles. We achieved autonomous motions of the asymmetric complex-shaped gel microparticles using chemical reaction energy. Additionally, we succeeded in biological functions of the asymmetric complex-shaped gel microparticles for cell-sized molecular robots using living cells and DNA molecules. Finally, we achieved the control of collective motions of microparticles using nonequilibrium electrical conditions. Through this study, we developed the basic technologies for the construction and control of dynamical cell-sized molecular robots.
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Report
(5 results)
Research Products
(138 results)
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[Journal Article] DNA cytoskeleton for stabilizing artificial cells2017
Author(s)
Kurokawa Chikako、Fujiwara Kei、Morita Masamune、Kawamata Ibuki、Kawagishi Yui、Sakai Atsushi、Murayama Yoshihiro、Nomura Shin-ichiro M.、Murata Satoshi、Takinoue Masahiro、Yanagisawa Miho
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 114
Issue: 28
Pages: 7228-7233
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] プログラマブルな性質を有するDNA ナノプレートからなるマイクロカプセルの形成, Microcapsular compartments composed of programmable DNA nanoplates2016
Author(s)
Daisuke Ishikawa, Yuki Suzuki, Chikako Kurokawa, Masayuki Ohara, Misato Tsuchiya, Masamune Morita, Miho Yanagisawa, Ryuji Kawano, Masayuki Endo, Masahiro Takinoue
Organizer
第54回日本生物物理学会
Place of Presentation
つくば国際会議場, 茨城
Year and Date
2016-11-25
Related Report
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[Presentation] Self-Assembled Microcapsule of Amphiphilic Janus DNA Nanoplates at the Water-Oil Interface2016
Author(s)
Daisuke Ishikawa, Yuki Suzuki, Chikako Kurokawa, Masayuki Ohara, Masamune Morita, Miho Yanagisawa, Ryuji Kawano, Masayuki Endo, *Masahiro Takinoue
Organizer
The 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS2016)
Place of Presentation
Convention Center Dublin, Dublin, Ireland.
Year and Date
2016-10-09
Related Report
Int'l Joint Research
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[Presentation] 荷電脂質膜界面における DNA ミクロ構造の形成2016
Author(s)
森田雅宗, 石川大輔, 野村 M. 慎一郎, 村田智, 柳澤実穂, 瀧ノ上正浩
Organizer
化学とマイクロ・ナノシステム学会 第33回研究会 (CHEMINAS33)
Place of Presentation
東京大学生産技術研究所, 東京
Year and Date
2016-04-25
Related Report
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[Presentation] 人工細胞構築を目指した微小流体の制御2016
Author(s)
瀧ノ上正浩
Organizer
生命動態システム科学四拠点,CREST,PRESTO,QBiC合同シンポジウム「生命動態の分子メカニズムと数理」,
Place of Presentation
広島シェラトンホテル, 広島
Year and Date
2016-03-25
Related Report
Invited
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