| Budget Amount *help |
¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
|
|---|
| Outline of Final Research Achievements |
One of the mechanisms for microbial parasites to evade host immune systems is antigenic variation, which alters target antigens of the host immune attack to escape from their recognition. We have developed a database named varDB by accumulating information on proteins regarding antigenic variations and analyzed their amino acid and nucleotide sequences to elucidate their evolutionary mechanisms. Mainly focusing on the malaria parasites, Plasmodium species, whose complete genome sequences are available, we have collected related sequence information based on the literature search and ortholog detection, to make the interspecies comparisons available. We have also developed a computational pipeline for analyzing their evolutionary relationships and applied it to human evolution and biosynthetic pathway evolution analyses.
|
