| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2014: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Outline of Final Research Achievements |
More than 85% of genes are expressed in the brain and maintain the structure and execute neural function. We have invented a TT method for profiling gene expression patterns of the whole brain in the three-dimensional coordinate. We have also developed a high-resolution motion capture method and detected subtle changes of walking motion and describe them with parameters of biomechanics. Using these methods, we analyzed a neuronal inherited disease model mouse with abnormal motion. Then, we found parameter changes in motion of abnormal mice and expression-area changes in gene expression of a group of genes in the beginning stages of the disease.
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