| Budget Amount *help |
¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
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| Outline of Final Research Achievements |
In this study, to investigate the effects of PM2.5 over the central and eastern China on the male reproductive system and immune system in the next generation, we administered PM2.5 intratracheally to pregnant mice. We found decreased daily sperm production (DSP) and seminiferous tubule degeneration in male offspring exposed to PM2.5 during the fetal period. Moreover, postnatal intratracheal administration of OVA to offspring exposed to PM2.5 in utero caused significant increases in the numbers of inflammatory cells. Our findings show that fetal exposure to PM2.5 that humans breathe has an effect male reproductive function and aggravated the sensitized immune system in male offspring.
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