Mechanism underlying accumulation of dietary life by the novel epigenetic factor Brd4
| Project/Area Number |
26282023
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
合田 敏尚 静岡県立大学, 食品栄養科学部, 教授 (70195923)
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| Co-Investigator(Renkei-kenkyūsha) |
HONMA Kazue 静岡県立大学, 食品栄養科学部, 教授 (80724765)
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| Research Collaborator |
HARIYA Natsuyo 山梨学院大学, 健康栄養学部, 准教授 (80732784)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Keywords | Brd4 / 生活習慣病 / エピゲノム / 食習慣 / ヒストン修飾 / ヒストンアセチル化 / IL-1b / ヒト横断研究 / 中鎖脂肪酸 / 食後高血糖 / インスリン抵抗性 / 脂肪組織 / 肝臓 |
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| Outline of Final Research Achievements |
Life style related diseases are developed by the accumulating information related to various lifestyle habits including dietary habits. In this study, we examined whether life style related diseases are developed by the accumulating dietary habits via the novel epigenetic factor Brd4. We found that Brd4 induceｄ expression of genes related to fat synthesis/accumulation and insulin sensitivity in the liver and adipose tissues. Moreover, Brd4 activation at the healthy state induced obesity and fatty liver, whereas Brd4 repression at the obesity state induced insulin resistance. In addition, we demonstrated in this study that epigenetic biomarkers indicating Brd4 activation would predicts development of life style related diseases.
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] Diseases2016
Author(s)
Kubota T, Miyake K, Hariya N, Nguyen Quoc VT, Mochizuki K.
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Journal Title
Prader-Willi syndrome: the disease that opened up epigenomic-based preemptive medicine.
Volume: 4(1)
Issue: 1
Pages: 15-15
DOI
Related Report
Peer Reviewed
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[Journal Article] Morphological, biochemical, transcriptional and epigenetic responses to fasting and refeeding in intestine of Xenopus laevis.2016
Author(s)
Tamaoki, K., Okada, R., Ishihara, A., Shiojiri, N., Mochizuki, K., Goda, T., Yamauchi, K.
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Journal Title
Cell Biosci.
Volume: 6
Issue: 1
Pages: 2-2
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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