Development of epigenome biomakers reflecting the eating habit
Project/Area Number |
26282027
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Eating habits
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Research Institution | University of Shizuoka |
Principal Investigator |
GODA Toshinao 静岡県立大学, 食品栄養科学部, 教授 (70195923)
|
Co-Investigator(Kenkyū-buntansha) |
市川 陽子 静岡県立大学, 食品栄養科学部, 准教授 (50269495)
望月 和樹 山梨大学, 総合研究部, 准教授 (80423838)
本間 一江 静岡県立大学, 食品栄養科学部, 助教 (80724765)
|
Co-Investigator(Renkei-kenkyūsha) |
KOBAYASHI Kimiko 静岡県立大学, 食品栄養科学部, 教授 (90215319)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
|
Keywords | エピゲノム / バイオマーカー / 食後高血糖 / 慢性炎症 / 末梢血 |
Outline of Final Research Achievements |
We have demonstrated using animal models of type two diabetes and obesity that the history of postprandial hyperglycemia is reflected by a change in the responding capability regarding the expression of the genes related to inflammation and insulin resistance in the peripheral leukocytes and the liver. The mononuclear cells exposed to a high glucose concentration for 24h showed persistently elevated levels of the mRNA and histone H3 acetylation (an epigenetic modification) of TNFa gene, which plays a pivotal role in inflammation and insulin resistance. Candidates of epigenome biomarkers for the history of postprandial glucose spikes include a hepatocyte-derived micro RNA and plasma soluble cell adhesion molecules.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] Transcription elongation factor Brd4-P-TEFb accelerates intestinal differentiation-associated SLC2A5 gene expression.2016
Author(s)
Inamochi, Y., Dey, A., Nishiyama, A., Kubota, T., Ozato, K., Goda, T., Mochizuki, K.
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Journal Title
Biochemistry and Biophysics Reports
Volume: 7
Pages: 150-156
Related Report
Peer Reviewed
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[Journal Article] Glycemic response in healthy Japanese subjects after consuming potatoes and white rice.2016
Author(s)
Wakasugi, Y., Hashidume, S., Sano, A., Mochizuki, K., Goda, T., Ichikawa, Y.
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Journal Title
J. ARAHE
Volume: 23 (1)
Pages: 1-8
Related Report
Peer Reviewed
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