| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Outline of Final Research Achievements |
We have clarified the protein expression level of nutrient transporters at the brush-border membrane of the human placental barrier formed by single syncytiotrophoblast layer. We have also clarified the protein expression in rat placental barrier formed by double syncytiotrophoblast layers, for estimating placental permeability of transporter substrates across the rat placenta. The higher placental permeability of transporter substrates was observed, however, the estimated permeability was not highly consistent with the measured permeability. There have been thought that two syncytiotrophoblast layers in rodents act functionally as a single layer, but this appears not to be true since we found that MDR1 and BCRP transporters are localized in the second syncytiotrophoblast layer. We need to consider the presence of transporters in the second syncytiotrophoblast layer for estimating placental permeability.
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