Low overpressure shock wave for treatment in the deep brain
| Project/Area Number |
26282116
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Tohoku University |
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Principal Investigator |
TOMINAGA Teiji 東北大学, 医学(系)研究科(研究院), 教授 (00217548)
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| Co-Investigator(Kenkyū-buntansha) |
齋藤 竜太 東北大学, 医学(系)研究科(研究院), 助教 (10400243)
中川 敦寛 東北大学, 大学病院, 助教 (10447162)
大谷 清伸 東北大学, 流体科学研究所, 助教 (80536748)
合田 圭介 東京大学, 理学(系)研究科(研究院), 教授 (70518696)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Keywords | 衝撃波 / 低侵襲治療 / 医工学 / 医療機器 / 医工連携 / 医療機器開発 / 外傷性脳損傷 / 高速度画像 / 衝撃波工学 / 薬剤デリバリー |
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| Outline of Final Research Achievements |
The purpose of present study is to clarify the effect of low overpressure shock wave (SW) in the central nervous system and to obtain basic understanding for development of drug delivery system using SW in the deep brain lesion. We first applied low overpressure SW in the animal brain and evaluated histological findings. We also evaluated the wave propagation in the brain phantom using high speed photograph and pressure measurement. We then made prototype for low overpressure SW applicator and applied dye liquid in the porcine brain after craniotomy and showed that application of low overpressure SW enhances the distribution of dye compared to mere injection of small amount liquid.
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] Intraparenchymal ultrasound application and improved distribution of infusate with convection-enhanced delivery in rodent and nonhuman primate brain.2016
Author(s)
Mano Y, Saito R, Haga Y, Matsunaga T, Zhang R, Chonan M, Haryu S, Shoji T, Sato A, Sonoda Y, Tsuruoka N, Nishiyachi K, Sumiyoshi A, Nonaka H, Kawashima R, Tominaga T.
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Journal Title
J Neurosurg.
Volume: 124(5)
Issue: 5
Pages: 1490-500
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Intraventricular hemorrhage on initial computed tomography as marker of diffuse axonal injury after traumatic brain injury.2015
Author(s)
Mata-Mbenba D, Mugikura S, Nakagawa A, Murata T, Kato Y, Tatewaki Y, Li Li, Takase K, Ishii K, Kushimoto S, Tominaga T, Takahashi S.
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Journal Title
J Neurotrauma
Volume: 32(5)
Pages: 359-365
Related Report
Peer Reviewed
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[Journal Article] Pulsed Laser-induced Liquid Jet System for Treatment of Sellar and Parasellar Tumors: Safety Evaluation.2015
Author(s)
Nakagawa A, Ogawa Y, Amano K, Ishii Y, Tahara S, Horiguchi K, Kawamata T, Yano S, Arafune T, Washio T, Kuratsu JI, Saeki N, Okada Y, Teramoto A, Tominaga T.
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Journal Title
J Neurol Surg A Cent Eur Neurosurg.
Volume: 76(6)
Pages: 473-482
Related Report
Peer Reviewed
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[Journal Article] The Dissection Profile and Mechanism of Tissue-Selective Dissection of the Piezo Actuator-Driven Pulsed Water Jet as a Surgical Instrument: Laboratory Investigation Using Swine Liver.2014
Author(s)
Yamada M, Nakano T, Nakagawa A, Sato C, Fujishima F, Tanno H, Kawagishi N, Miyata G, Sato A, Tominaga T, Satomi S, Ohuchi N.
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Journal Title
Eur Surg Res
Volume: 53
Issue: 1-4
Pages: 61-72
DOI
Related Report
Peer Reviewed
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