Low overpressure shock wave for treatment in the deep brain

• Project/Area Number: 26282116
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Tohoku University
• Principal Investigator: TOMINAGA Teiji 東北大学, 医学(系)研究科(研究院), 教授 (00217548)
• Co-Investigator(Kenkyū-buntansha): 齋藤 竜太 東北大学, 医学(系)研究科(研究院), 助教 (10400243) ; 中川 敦寛 東北大学, 大学病院, 助教 (10447162) ; 大谷 清伸 東北大学, 流体科学研究所, 助教 (80536748) ; 合田 圭介 東京大学, 理学(系)研究科(研究院), 教授 (70518696)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000); Fiscal Year 2016: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
• Keywords: 衝撃波 / 低侵襲治療 / 医工学 / 医療機器 / 医工連携 / 医療機器開発 / 外傷性脳損傷 / 高速度画像 / 衝撃波工学 / 薬剤デリバリー

Outline of Final Research Achievements

The purpose of present study is to clarify the effect of low overpressure shock wave (SW) in the central nervous system and to obtain basic understanding for development of drug delivery system using SW in the deep brain lesion. We first applied low overpressure SW in the animal brain and evaluated histological findings. We also evaluated the wave propagation in the brain phantom using high speed photograph and pressure measurement. We then made prototype for low overpressure SW applicator and applied dye liquid in the porcine brain after craniotomy and showed that application of low overpressure SW enhances the distribution of dye compared to mere injection of small amount liquid.

Research Products

• [Journal Article] Convection-enhanced Delivery of Therapeutics for Malignant Gliomas. (2017)
  • Author(s): Saito R, Tominaga T.
  • Journal Title: Neurol Med Chir (Tokyo). Volume: 57(1) Pages: 8-16
  • NAID: 130005290681
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] New Application of Actuator-Driven Pulsed Water Jet for Spinal Cord Dissection: An Experimental Study in Pigs. (2017)
  • Author(s): Endo T, Wenting J, Nakagawa A, Endo H, Sagae Y, Iwasaki M, Tominaga T.
  • Journal Title: J Neurol Surg A Cent Eur Neurosurg. Volume: 78(2) Issue: 02 Pages: 137-143
  • DOI: 10.1055/s-0036-1584919
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A laser-induced pulsed water jet for layer-selective submucosal dissection of the esophagus. (2016)
  • Author(s): Nakano T, Sato C, Yamada M, Nakagawa A, Yamamoto H, Fujishima F, Tominaga T, Satomi S, Ohuchi N.
  • Journal Title: Laser Ther. Volume: 25(3) Pages: 185-191
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Use of water jet instruments in gastrointestinal endoscopy. (2016)
  • Author(s): Nakano T, Sato C, Sakurai T, Kamei T, Nakagawa A, Ohuchi N
  • Journal Title: World Journal of Gastrointestinal Endoscopy Volume: 8 Issue: 3 Pages: 122-127
  • DOI: 10.4253/wjge.v8.i3.122
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of a newly developed piezo actuator-driveb pulsed water jet system for liver resection in a surviving swine model. (2016)
  • Author(s): Nakanishi C, Nakano T, Nakagawa A, Sato C, Yamada M, Kawagishi N, Tomonaga T, Ohuchi N
  • Journal Title: BioMedical Engineering OnLine Volume: 15 Issue: 1 Pages: 9-9
  • DOI: 10.1186/s12938-016-0126-9
  • Peer Reviewed / Open Access
• [Journal Article] Ventricle wall dissection and vascular preservation with the pulsed water jet device: novel tissue dissector for flexible neuroendoscopic surgery. (2016)
  • Author(s): Kawaguchi T, Nakagawa A, Endo T, Fujimura M, Sonoda Y, Tominaga T.
  • Journal Title: J Neurosurg. Volume: 124(3) Issue: 3 Pages: 817-22
  • DOI: 10.3171/2015.3.jns142121
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Local convection-enhanced delivery of an anti-CD40 agonistic monoclonal antibody induces antitumor effects in mouse glioma models. (2016)
  • Author(s): Shoji T, Saito R, Chonan M, Shibahara I, Sato A, Kanamori M, Sonoda Y, Kondo T, Ishii N, Tominaga T.
  • Journal Title: Neuro Oncol. Volume: 18(8) Issue: 8 Pages: 1120-8
  • DOI: 10.1093/neuonc/now023
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Intraparenchymal ultrasound application and improved distribution of infusate with convection-enhanced delivery in rodent and nonhuman primate brain. (2016)
  • Author(s): Mano Y, Saito R, Haga Y, Matsunaga T, Zhang R, Chonan M, Haryu S, Shoji T, Sato A, Sonoda Y, Tsuruoka N, Nishiyachi K, Sumiyoshi A, Nonaka H, Kawashima R, Tominaga T.
  • Journal Title: J Neurosurg. Volume: 124(5) Issue: 5 Pages: 1490-500
  • DOI: 10.3171/2015.3.jns142152
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 「真の」アンメットニーズに基づいた医療機器開発：東北大学病院ベッドサイドソリューションプログラム（ASU）とバイオデザイン． (2016)
  • Author(s): 中川敦寛、池田浩治、池野文昭、伊藤香織、五十嵐修一、高橋千明、冨永悌二．
  • Journal Title: 機能的脳神経外科 Volume: 55 Pages: 73-79
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] パルスレーザージェットメス：原理開発から臨床試験まで． (2016)
  • Author(s): 中川敦寛、川口奉洋、遠藤俊毅、小川欣一、山下慎一、荒船龍彦、加藤峰士、鷲尾利克、荒井陽一、冨永悌二．
  • Journal Title: レーザー研究 Volume: 44(3) Pages: 165-168
  • NAID: 130007957190
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Intraventricular hemorrhage on initial computed tomography as marker of diffuse axonal injury after traumatic brain injury. (2015)
  • Author(s): Mata-Mbenba D, Mugikura S, Nakagawa A, Murata T, Kato Y, Tatewaki Y, Li Li, Takase K, Ishii K, Kushimoto S, Tominaga T, Takahashi S.
  • Journal Title: J Neurotrauma Volume: 32(5) Pages: 359-365
  • Peer Reviewed
• [Journal Article] Pulsed Laser-induced Liquid Jet System for Treatment of Sellar and Parasellar Tumors: Safety Evaluation. (2015)
  • Author(s): Nakagawa A, Ogawa Y, Amano K, Ishii Y, Tahara S, Horiguchi K, Kawamata T, Yano S, Arafune T, Washio T, Kuratsu JI, Saeki N, Okada Y, Teramoto A, Tominaga T.
  • Journal Title: J Neurol Surg A Cent Eur Neurosurg. Volume: 76(6) Pages: 473-482
  • Peer Reviewed
• [Journal Article] Use of Actuator-Driven Pulsed Water Jet in Brain and Spinal Cord Cavernous Malformations Resection. (2015)
  • Author(s): Endo. T, Takahashi Y, Nakagawa A, Niizuma K, Fujimura M, Tominaga T.
  • Journal Title: Neurosurgery Volume: 11 (Suppl 3) Pages: 394-403
  • Peer Reviewed
• [Journal Article] パルスウォータージェットメスを用いた精密手術用治療器. (2015)
  • Author(s): 中川敦寛、遠藤敏毅、川口奉洋、冨永悌二．
  • Journal Title: 精密工学誌 Volume: 81(4) Pages: 293-297
  • NAID: 130005060668
  • Peer Reviewed
• [Journal Article] 生体模擬物質中の衝撃波伝播挙動． (2015)
  • Author(s): 大谷清伸, 中川敦寛, 中川桂一
  • Journal Title: M&M2015 火薬学会秋季研究発表会 Volume: 2015 Pages: 1-4
  • Peer Reviewed
• [Journal Article] 模擬モデルを用いた爆風による外傷性脳損傷機序解明に関する数値模擬． (2015)
  • Author(s): 大谷清伸, 中川敦寛, 沼田大樹．
  • Journal Title: M&M2015 材料力学カンファレンスプロシーディング Volume: 2015 Pages: 369-371
  • Peer Reviewed
• [Journal Article] The Dissection Profile and Mechanism of Tissue-Selective Dissection of the Piezo Actuator-Driven Pulsed Water Jet as a Surgical Instrument: Laboratory Investigation Using Swine Liver. (2014)
  • Author(s): Yamada M, Nakano T, Nakagawa A, Sato C, Fujishima F, Tanno H, Kawagishi N, Miyata G, Sato A, Tominaga T, Satomi S, Ohuchi N.
  • Journal Title: Eur Surg Res Volume: 53 Issue: 1-4 Pages: 61-72
  • DOI: 10.1159/000365288
  • Peer Reviewed
• [Journal Article] Early CT Findings to Predict Early Death in Patients with Traumatic Brain Injury: Marshall and Rotterdam CT Scoring Systems Compared in the Major Academic Tertiary Care Hospital in Northeastern Japan (2014)
  • Author(s): Mata-Mbemba D, Mugikura S, Nakagawa A, Murata T, Ishii K, Li L, Takase K, Kushimoto S, Takahashi S.
  • Journal Title: Acad Radiol Volume: 21(5) Pages: 605-611
  • Peer Reviewed
• [Journal Article] びまん性軸索損傷の画像 (2014)
  • Author(s): 古谷桂子、中川敦寛、冨永悌二．
  • Journal Title: ブレーンナーシング Volume: 30(2) Pages: 28-29
  • Peer Reviewed
• [Journal Article] Novel pulsed water jet system permits off-clamp partial nephrectomy in swine (2014)
  • Author(s): Yamashita S, Kamiyama Y, Nakagawa A, Kaiho Y, Tominaga T, Arai Y.
  • Journal Title: Internat J Urol Volume: 21(11) Issue: 11 Pages: 1181-1182
  • DOI: 10.1111/iju.12538
  • Peer Reviewed
• [Journal Article] Surgical Management of Traumatic Acute Subdural Hematoma in Adults (2014)
  • Author(s): Karibe H, Hayashi T, Hirano T, Kameyama M, Nakagawa A, Tominaga T.
  • Journal Title: A Review.Neuro Medic Chir (Tokyo) Volume: 54(11) Pages: 887-894
  • Peer Reviewed
• [Journal Article] Mechanics of the injected pulsejet into gelatin gel and evaluation of the effect by puncture and crack generation and growth (2014)
  • Author(s): Kato T, Arafune T, Washio T, Nakagawa A, Ogawa Y, Tominaga T, Sakuma I, Kobayashi E.
  • Journal Title: J Appl Phys Volume: 116 Pages: 074901-074901
  • Peer Reviewed
• [Journal Article] Measurement and analysis of internal stress distributions created in gelatin simulated-brain tissue by a pulsed laser-induced liquid jet (2014)
  • Author(s): Kato T, Arafune T, Washio T, Nakagawa A, Ogawa Y, Tominaga T, Sakuma I, Kobayashi E.
  • Journal Title: Proc. IEEE Volume: 2014 Pages: 4419-4421
  • Peer Reviewed
• [Journal Article] 神経・血管温存下に最大限の病変摘出を行う手術用治療器（パルスウォータージェットメス）の開発 (2014)
  • Author(s): 中川敦寛、冨永悌二
  • Journal Title: 臨床評価 Volume: 42 Pages: 129-135
  • Peer Reviewed
• [Journal Article] 高齢者頭部外傷の特徴と問題点 (2014)
  • Author(s): 刈部 博, 林 俊哲, 平野 孝幸, 亀山 元信, 中川 敦寛, 冨永 悌二
  • Journal Title: 脳神経外科ジャーナル Volume: 23 Pages: 965-972
  • NAID: 130004842118
  • Peer Reviewed
• [Presentation] ニーズに基づいた医療機器開発 - 東北大学ベッドサイドソリューションプログラム（インフラ）とバイオデザイン（方法） (2016)
  • Author(s): 中川敦寛、工藤大介、野村亮介、佐藤武揚、宮川乃理子、入野田崇、川副友、吉田良太朗、久志本成樹、冨永悌二．
  • Organizer: 第44回日本救急医学会学術総会
  • Place of Presentation: 新高輪プリンスホテル(東京都港区）
  • Year and Date: 2016-11-19
• [Presentation] 最大限の病変摘出と機能温存の両立を支援するパルスレーザージェットメス：薬事承認申請、市場創出に向けた取り組み. (2016)
  • Author(s): 中川敦寛、小川欣一、遠藤俊毅、川口奉洋、齋藤竜太、藤村幹、山下慎一、神山佳展、中野徹、中西史、櫻井直、國方彦志、鈴木智之、冨永悌二.
  • Organizer: 第37回 日本レーザー医学会総会
  • Place of Presentation: 旭川グランドホテル（北海道旭川市）
  • Year and Date: 2016-10-21
• [Presentation] Mechanism of shock wave propagation within the cell. (2016)
  • Author(s): Nakagawa A, Ohtani K, Harada N, Tominaga T.
  • Organizer: IFS Collaborative Research Forum (AFI-2016)
  • Place of Presentation: Sendai Kokusai Center(宮城県仙台市）
  • Year and Date: 2016-10-11
  • Int'l Joint Research
• [Presentation] 高齢者頭部外傷の現状 宮城県頭部外傷研究会2013年解析から． (2016)
  • Author(s): 中川敦寛、刈部博、亀山元信、麦倉俊司、Daddy Matas、古谷桂子、石ケ森朝香、上之原広司、吉田昌弘、荒井啓晶、西村真実、遠藤英徳、成田徳雄、石川修一、高橋康、川口奉洋、久志本成樹、冨永悌二．
  • Organizer: 第70回日本脳神経外科学会総会
  • Place of Presentation: 福岡国際会議場(福岡県福岡市）
  • Year and Date: 2016-09-28
• [Presentation] Maxillofacial fractures in patients with closed head trauma: prevalence and association with intracranial lesions (Dr. Daddy Mata-Mbembaの代行）． (2016)
  • Author(s): Matas D, Mugikura S, Nakagawa A, Tominaga T．
  • Organizer: 16th International Symposium on Intracranial Pressure
  • Place of Presentation: Boston,USA
  • Year and Date: 2016-06-28
• [Presentation] Profile of traumatic brain injury in Miyagi prefecture 2013. (2016)
  • Author(s): Nakagawa A, Karibe H, Kameyama M, Uenohara H, Yoshida M, Arai M, Kawaguchi T, Tominaga T.
  • Organizer: 16th International Symposium on Intracranial Pressure（Boston）
  • Place of Presentation: Boston,USA
  • Year and Date: 2016-06-28
  • Int'l Joint Research
• [Presentation] Mechanism of bTBI: Evaluation of wave transmission by shock wave brain injury model． (2016)
  • Author(s): Nakagawa A, Ohtani K, Nakagawa K, Tominaga T．
  • Organizer: 16th International Symposium on Intracranial Pressure（Boston）
  • Place of Presentation: Boston,USA
  • Year and Date: 2016-06-28
  • Int'l Joint Research
• [Presentation] Mechanism of bTBI: Insights from shock wave research． (2016)
  • Author(s): Nakagawa A, Ohtani K, Armonda R, Tominaga T．
  • Organizer: Japan-US Technical Information Exchange Forum on Blast Injury (JUFBI 2016)
  • Place of Presentation: ニュー山王ホテル（東京都港区）
  • Year and Date: 2016-06-13
• [Presentation] 外傷性脳損傷 頭蓋顔面損傷の急性期から慢性期までの至適治療：神経外傷医の観点から． (2016)
  • Author(s): 中川敦寛、今井啓道、麦倉俊司、川口奉洋、工藤大介、Daddy Matas、佐藤顕光、館正弘、久志本成樹、冨永悌二．
  • Organizer: 第59回日本形成外科学会総会・学術集会
  • Place of Presentation: 福岡国際会議場(福岡県福岡市）
  • Year and Date: 2016-04-13
• [Presentation] ピエゾ方式パルスウォータージェットメス：有用性と安全性 (2014)
  • Author(s): 中川敦寛、遠藤俊毅、園田順彦、齋藤竜太、岩崎真樹、藤村幹、 川口奉洋、遠藤英徳、小川欣一、冨永悌二
  • Organizer: 第53回日本生体医工学会大会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2014-06-24 – 2014-06-26
• [Presentation] Understanding the mechanisms of shock wave injury: implications for blast-induced TBI and development of a novel neurosurgical instrument (2014)
  • Author(s): Nakagawa A, Ohtani K, Goda K, Tominaga T.
  • Organizer: invited lecture
  • Place of Presentation: University of Pittsburgh（Pittsburgh, U.S.A.）
  • Year and Date: 2014-05-21
  • Invited
• [Presentation] Mechanism of traumatic brain injury at distant locations after blast wave exposure: Preliminary results from animal and phantom experiments (2014)
  • Author(s): Nakagawa A, Ohtani K, Goda K, Tominaga T.
  • Organizer: Grand Round
  • Place of Presentation: Eastern Virginia Medical School（Norfolk, U.S.A)
  • Year and Date: 2014-05-19
  • Invited
• [Presentation] 最大限の病変摘出と機能温存の両立を支援するパルスジェットメス：薬事承認申請、市場創出に向けた取り組み (2014)
  • Author(s): 中川敦寛、小川欣一、遠藤俊毅、園田順彦、岩崎真樹、斎藤竜太、山下慎一、中野徹、中西史、櫻井、國方彦志、中佑治、鈴木、川本俊輔、冨永悌二
  • Organizer: 第23回脳神経外科手術と機器学会
  • Place of Presentation: ヒルトン福岡シーホーク（福岡県福岡市）
  • Year and Date: 2014-04-18 – 2014-04-19
• [Patent(Industrial Property Rights)] 薬剤噴流生成装置、及び薬剤噴流生成装置の薬剤噴流生成方法 (2017)
  • Inventor(s): 中川敦寛、川口奉洋、冨永悌二、金田道寛
  • Industrial Property Rights Holder: 中川敦寛、川口奉洋、冨永悌二、金田道寛
  • Industrial Property Rights Type: 特許
  • Filing Date: 2017-01-20
  • Overseas
• [Patent(Industrial Property Rights)] 噴流生成装置、及び噴流生成装置の噴流生成方法 (2016)
  • Inventor(s): 中川敦寛、川口奉洋、冨永悌二、金田道寛
  • Industrial Property Rights Holder: 中川敦寛、川口奉洋、冨永悌二、金田道寛
  • Industrial Property Rights Type: 特許
  • Filing Date: 2016-08-25
  • Overseas