| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Outline of Final Research Achievements |
In the present study, we focused on amyloid beta (Aβ) proteins in an eye lens for diagnosing Alzheimer's disease (AD). Based on the coherent Raman scattering technique, we tried to develop a novel label-free diagnostic system to detect Aβ in an eye lens. We succeeded in obtaining label-free ex vivo images of human eye lens, but we could not find any spectroscopic signature of Aβ within the research period. One of the noteworthy results is that we unexpectedly visualized organelles called rootlet in photoreceptor cells with label-free manner.
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