Development of coherent Raman imaging method for diagnosing Alzheimers Disease
Project/Area Number |
26282117
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Biomedical engineering/Biomaterial science and engineering
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Research Institution | University of Tsukuba |
Principal Investigator |
KANO Hideaki 筑波大学, 数理物質系, 准教授 (70334240)
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Co-Investigator(Kenkyū-buntansha) |
加治 優一 筑波大学, 医学医療系, 准教授 (50361332)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
|
Keywords | ラマン / CARS / 水晶体 / アルツハイマー / アルツハイマー病 |
Outline of Final Research Achievements |
In the present study, we focused on amyloid beta (Aβ) proteins in an eye lens for diagnosing Alzheimer's disease (AD). Based on the coherent Raman scattering technique, we tried to develop a novel label-free diagnostic system to detect Aβ in an eye lens. We succeeded in obtaining label-free ex vivo images of human eye lens, but we could not find any spectroscopic signature of Aβ within the research period. One of the noteworthy results is that we unexpectedly visualized organelles called rootlet in photoreceptor cells with label-free manner.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] SHG-specificity of cellular Rootletin filaments enables naive imaging with universal conservation2017
Author(s)
Toshihiro Akiyama, Akihito Inoko, Yuichi Kaji, Shigenobu Yonemura, Kisa Kakiguchi, Hiroki Segawa, Kei Ishitsuka, Masaki Yoshida, Osamu Numata, Philippe Leproux, Vincent Couderc, Tetsuro Oshika, Hideaki Kano
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Journal Title
Scientific Reports
Volume: 7
Issue: 1
Pages: 39967-39967
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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