Development of biomaterials based on analysis of molecular processes at cell-material interfaces
| Project/Area Number |
26282118
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
原 正彦 東京工業大学, 総合理工学研究科(研究院), 教授 (50181003)
矢野 隆章 東京工業大学, 総合理工学研究科(研究院), 助教 (90600651)
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| Co-Investigator(Renkei-kenkyūsha) |
TANAKA Masaru 九州大学, 先導物質化学研究所, 教授 (00322850)
MORITA Shigeaki 大阪電気通信大学, 工学部, 教授 (20388739)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
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| Keywords | バイオインターフェース / 生体材料 / ナノバイオ / 表面・界面 / 表面分光 |
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| Outline of Final Research Achievements |
By understanding the molecular process at the interface between cell and artificial material, we aimed to elucidate the mechanism underlying bioinertness and biocompatibility of materials. We found that the water molecules at the interface with the structure and dynamics different from bulk water are playing an important role in the expression of the anti-protein adsorption property and the anti-cell adhesion property.
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Report
(4 results)
Research Products
(92 results)
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[Journal Article] Surface force analysis of pyrite: its reactivity to amino acid adsorption2016
Author(s)
Narangerel, G., Matsuzaki, N., Nakazawa, Y., Afrin, R., Aono, M., Yano, T., Hayashi, T., Hara, M.
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Journal Title
Advances in Materials Physics and Chemistry
Volume: 6
Issue: 07
Pages: 167-176
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Probing edge-activated resonant Raman scattering from mechanically exfoliated 2D MoO3 nanolayers2015
Author(s)
Yano, T., Yoshida, K., Hayamizu, Y., Hayashi, T., Ohuchi, F., Hara, M.
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Journal Title
2D Materials
Volume: 2
Issue: 3
Pages: 035004-035004
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Controlling the Visible Electromagnetic Resonances of Si/SiO2 Dielectric Core-Shell Nanoparticles by Thermal Oxidation2015
Author(s)
Tsuchimoto, Y., Yano, T., Hada, M., Nakamura, K.G., Hayashi, T., Hara, M.
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Journal Title
Small
Volume: 11
Issue: 37
Pages: 4844-4849
DOI
Related Report
Peer Reviewed
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[Journal Article] Tip-enhanced THz Raman spectroscopy for local temperature determination at the nanoscale2015
Author(s)
Balois, M.V., Hayazawa, N., Catalan, F.C., Kawata, S., Yano, T., Hayashi, T
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Journal Title
Anal. Bioanal. Chem
Volume: 407
Issue: 27
Pages: 8205-8213
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Molecular recognition imaging at nanoscales2016
Author(s)
Takashi Nyu Tatsuhiro Maekawa Kasinan Suthiwanich Tomohiro Hayashi
Organizer
12th International Conference on Nano-Molecular Electronics (ICNME 2016)
Place of Presentation
神戸国際会議場
Year and Date
2016-12-14
Related Report
Int'l Joint Research / Invited
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[Presentation] 生体不活性特性と界面水分子2015
Author(s)
林智広
Organizer
第62回応用物理学会春季学術講演会
Place of Presentation
東海大学 湘南キャンパス
Year and Date
2015-03-11 – 2015-03-15
Related Report
Invited
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