| Project/Area Number |
26282118
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
原 正彦 東京工業大学, 総合理工学研究科(研究院), 教授 (50181003)
矢野 隆章 東京工業大学, 総合理工学研究科(研究院), 助教 (90600651)
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| Co-Investigator(Renkei-kenkyūsha) |
TANAKA Masaru 九州大学, 先導物質化学研究所, 教授 (00322850)
MORITA Shigeaki 大阪電気通信大学, 工学部, 教授 (20388739)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
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| Keywords | バイオインターフェース / 生体材料 / ナノバイオ / 表面・界面 / 表面分光 |
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| Outline of Final Research Achievements |
By understanding the molecular process at the interface between cell and artificial material, we aimed to elucidate the mechanism underlying bioinertness and biocompatibility of materials. We found that the water molecules at the interface with the structure and dynamics different from bulk water are playing an important role in the expression of the anti-protein adsorption property and the anti-cell adhesion property.
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