| Project/Area Number |
26282121
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Okayama University |
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Principal Investigator |
Iribe Gentaro 岡山大学, 医歯(薬)学総合研究科, 准教授 (90284885)
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| Co-Investigator(Renkei-kenkyūsha) |
NISHIDA Motohiro 岡崎統合バイオサイエンスセンター, 教授 (90342641)
NARUSE Keiji 岡山大学, 医歯薬学総合研究科, 教授 (40252233)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Keywords | 機械感受性 / 活性酸素 / ミトコンドリア / 電子伝達系 / TRPC3チャネル / 生理学 / 循環器・高血圧 / 伸展刺激 / TRPCチャネル |
|---|
| Outline of Final Research Achievements |
Chronic mechanical load to myocardium due to hypertension or cardiac valve diseases leads to the heart failure. Any substances that mediate such response look “evil”, though, they also have physiological roles. Therefore, it is important to understand their physiological and beneficial roles, otherwise any attempts aimed to eliminate such “evil” substances would have side effects by eliminating their physiologically required roles. In the present study, roles of reactive oxygen species (ROS), which has been regarded as an “evil” substance, in physiological and pathological response to myocardial mechanical load was studied, and its role in linking cardiac physiology and pathophysiology was demonstrated. The present results may be useful for the development in safe methods for the treatment and/or prevention of heart failure without side effects.
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