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Development of breast tumor imaging using near-fluorescent novel-metal clusters

Research Project

Project/Area Number 26282129
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Jin Takashi  国立研究開発法人理化学研究所, 生命システム研究センター, チームリーダー (80206367)

Co-Investigator(Kenkyū-buntansha) 塚崎 克和  国立研究開発法人理化学研究所, 生命システム研究センター, 研究員 (70452381)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Keywords生体イメージング / 近赤外 / 蛍光 / 乳がん / 貴金属ナノクラスター / バイオイメージング / 近赤外蛍光イメージング
Outline of Final Research Achievements

In this study, we prepared near-infrared (NIR) emitting gold nanocluster (AuNCs) protected by bovine serum albumin (BSA) for in vivo fluorescence imaging. The emission maximum of the NIR-emitting AuNCs was 700 nm, and its fluorescence quantum yield was 1.7 % in phosphate buffered saline. For breast tumor imaging, anti-HER2 antibody (Herceptin) was conjugated to the AuNCs by using carbodiimide coupling. NIR fluorescence imaging of the breast tumors was achieved for human breast cancer cell implanted nude mice using HER2-AuNCs

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (11 results)

All 2017 2016 2015 2014 Other

All Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 7 results,  Acknowledgement Compliant: 2 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Near-Infrared Emitting PbS Quantum Dots for in Vivo Fluorescence Imaging of the Thrombotic State in Septic Mouse Brain2016

    • Author(s)
      Yukio Imamura, Sayumi Yamada, Setsuko Tsuboi, Yuko Nakane, Yoshikazu Tsukasaki, Akihito Komatsuzaki, and Takashi Jin
    • Journal Title

      Molecules

      Volume: 21 Issue: 8 Pages: 1080-1080

    • DOI

      10.3390/molecules21081080

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Applications of Highly Bright PbS Quantum Dots to Non-Invasive Near-Infrared Fluorescence Imaging in the Second Optic Window2016

    • Author(s)
      Takashi Jin, Yukio Imamura
    • Journal Title

      ECS Journal of Solid State Science and Technology

      Volume: 5 Issue: 4 Pages: 623-631

    • DOI

      10.1039/c5md00580a

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Applications of Highly Bright PbS Quantum Dots to Non-invasive Near-Infrared Fluorescence Imaging in the Second Optical Window2016

    • Author(s)
      Takashi Jin and Yukio Imamura
    • Journal Title

      ECS J. Solid State Sci.Technol.

      Volume: 5 Issue: 1 Pages: 3138-3146

    • DOI

      10.1149/2.0171601jss

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Compact and stable SNAP ligand-conjugated quantum dots as a fluorescent probe for single-molecule imaging of dynein motor protein.2015

    • Author(s)
      Ohyanagi T, Shima T, Okada Y, Tsukasaki Y, Komatsuzaki A, Tsuboi S, Jin T.
    • Journal Title

      Chemical Communications

      Volume: 51 Issue: 80 Pages: 14836-14839

    • DOI

      10.1039/c5cc05526a

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 生体の第2光学窓における非侵襲近赤外蛍光イメージング2015

    • Author(s)
      神 隆
    • Journal Title

      日本レーザー医学会誌

      Volume: 39 Pages: 195-200

    • NAID

      130005540278

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Compact Halo-Ligand Conjugated Quantum Dots for Multicolored Single-Molecule Imaging of Overcrowding GPCR Proteins on Cell Membrane2015

    • Author(s)
      Komatsuzaki, A., Ohyanagi, T., Tsukasaki, Y., Miyanaga, Y., Ueda, M. and Jin, T.
    • Journal Title

      Small

      Volume: 11 Issue: 12 Pages: 1396-1401

    • DOI

      10.1002/smll.201402508

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recombinant protein (EGFP-Protein G)-coated PbS quantum dots for in vitro and in vivo dual fluorescence (visible and second-NIR) imaging of breast tumors2015

    • Author(s)
      Sasaki A., Tsukasaki Y., Komatsuzaki A., Sakata T., Yasuda H. and Jin T.
    • Journal Title

      Nanoscale

      Volume: 7 Issue: 12 Pages: 5115-5119

    • DOI

      10.1039/c4nr06480a

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synthesis and optical properties of emission-tunable PbS/CdS core-shell QDs in vivo fluorescence imaging in the second near-infrared window2014

    • Author(s)
      Y. Tsukasaki, M. Morimatsu, G. Nishimura, T. Sakata, H. Yasuda, A. Komaytsuzaki, TM. Watanabe, T. Jin
    • Journal Title

      RSC Adv.

      Volume: 4 Issue: 77 Pages: 41164-41171

    • DOI

      10.1039/c4ra06098a

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A short-wavelength infrared emiting multimodal probe for non-invasive visualization of phagocyte cell migration in living mice2014

    • Author(s)
      Tsukasaki, Y., Komatsuzaki, A., Mori, Y., Ma, Q., Yoshioka, Y. and Jin, T.
    • Journal Title

      Chemical Communication

      Volume: 50 Issue: 92 Pages: 14356-14359

    • DOI

      10.1039/c4cc06542e

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Book] Smart Biomarker-Coated PbS Quantum Dots for Deeper Near-Infrared Fluorescence Imaging in the Second Optical Window2017

    • Author(s)
      Takashi Jin, Akira Suzuki and Yukio Imamura
    • Total Pages
      27
    • Publisher
      Pan Stanford Publishing
    • Related Report
      2016 Annual Research Report
  • [Remarks] 生命システム研究センター ナノバイオプローブ研究チーム チームリーダー 神 隆 (D. Sci.)

    • URL

      http://www.riken.jp/research/labs/qbic/cell_dyn/nanobio_probes/

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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