Development of breast tumor imaging using near-fluorescent novel-metal clusters
Project/Area Number |
26282129
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Biomedical engineering/Biomaterial science and engineering
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Research Institution | Institute of Physical and Chemical Research |
Principal Investigator |
Jin Takashi 国立研究開発法人理化学研究所, 生命システム研究センター, チームリーダー (80206367)
|
Co-Investigator(Kenkyū-buntansha) |
塚崎 克和 国立研究開発法人理化学研究所, 生命システム研究センター, 研究員 (70452381)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
|
Keywords | 生体イメージング / 近赤外 / 蛍光 / 乳がん / 貴金属ナノクラスター / バイオイメージング / 近赤外蛍光イメージング |
Outline of Final Research Achievements |
In this study, we prepared near-infrared (NIR) emitting gold nanocluster (AuNCs) protected by bovine serum albumin (BSA) for in vivo fluorescence imaging. The emission maximum of the NIR-emitting AuNCs was 700 nm, and its fluorescence quantum yield was 1.7 % in phosphate buffered saline. For breast tumor imaging, anti-HER2 antibody (Herceptin) was conjugated to the AuNCs by using carbodiimide coupling. NIR fluorescence imaging of the breast tumors was achieved for human breast cancer cell implanted nude mice using HER2-AuNCs
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Compact Halo-Ligand Conjugated Quantum Dots for Multicolored Single-Molecule Imaging of Overcrowding GPCR Proteins on Cell Membrane2015
Author(s)
Komatsuzaki, A., Ohyanagi, T., Tsukasaki, Y., Miyanaga, Y., Ueda, M. and Jin, T.
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Journal Title
Small
Volume: 11
Issue: 12
Pages: 1396-1401
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A short-wavelength infrared emiting multimodal probe for non-invasive visualization of phagocyte cell migration in living mice2014
Author(s)
Tsukasaki, Y., Komatsuzaki, A., Mori, Y., Ma, Q., Yoshioka, Y. and Jin, T.
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Journal Title
Chemical Communication
Volume: 50
Issue: 92
Pages: 14356-14359
DOI
Related Report
Peer Reviewed / Open Access
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