| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Outline of Final Research Achievements |
To decrease the victims of cancer death, the diagnosis of cancer as well as the therapy is important. Circulating tumor cells (CTCs) have received attention for cancer diagnosis and decisions on chemotherapeutic courses. For these purposes, the isolation of CTCs has been expected. In this study, we examined the possibility of capturing CTCs via an adhesion-based method using new poly(2-methoxyethyl acrylate)(PMEA) analogous polymers by controlling the chemical structure, surface properties and intermediate water structure through precision polymer synthesis. Tumor cells can adhere blood compatible PMEA analogous polymers via integrin-dependent and independent mechanism after 30 min and 1 h of incubation, suggesting that these blood compatible polymers possess the ability to capture CTCs from peripheral blood and inform decisions on chemotherapeutic courses.
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