| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
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| Outline of Final Research Achievements |
In recent years, drugs are becoming harder to be water-soluble in drug development. Due to its poor water solubility, the poorly water soluble drugs have low physiological activity. As a means for improving poorly water-soluble drugs, drug nanocrystals where the particle diameter of the drug is reduced to manometer size have attracted attention. In this research project, chemical calculation was introduced for drug nanocrystal preparation. In particular, found that the oil-water partition coefficient (log P value) is an important factor for preparing drug nanocrystals. We also succeeded in demonstrating the maintaining the long-term stability of the nanocrystal water-dispersion. In addition, it was found that in the nanocrystal ophthalmic preparation, the intraocular migration is enhanced more than the commercially available eye drop suspension. We succeeded in obtaining useful knowledge in future nanocrystal formulation development.
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