Tomographic imaging of a cell by laser ultrasound microscope with femto-second laser
| Project/Area Number |
26282142
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
鷲尾 勝由 東北大学, 工学(系)研究科(研究院), 教授 (20417017)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUURA Yuji 東北大学, 大学院医工学研究科, 教授 (10241530)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2014: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
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| Keywords | 光超音波 / レーザー / 細胞 / バイオメカニクス / フェムト秒レーザー |
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| Outline of Final Research Achievements |
A laser ultrasound microscope with cellular resolution was developed by means of measuring high frequency laser ultrasound signal generated by ultra-short pulsed laser with ZnO thin film sensor. 3T3-L1 cells, which proliferated from fibroblast to adipocyte, were cultured on PET film and observed by the laser ultrasound microscope. C-mode and B-mode images were successfully obtained by the system. The method is capable of measuring sound speed and acoustic impedance and finally visualizes the distribution of Young’s elastic modulus and density within a cell. The method may contribute to the future investigation on cellular biomechanics.
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Report
(4 results)
Research Products
(13 results)
