| Project/Area Number |
26282143
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Gunma University |
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Principal Investigator |
SONE Hayato 群馬大学, 大学院理工学府, 教授 (80344927)
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| Co-Investigator(Kenkyū-buntansha) |
保坂 純男 群馬大学, 大学院理工学府, 特任教授 (10334129)
坂田 利弥 東京大学, 大学院工学系研究科(工学部), 准教授 (70399400)
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| Research Collaborator |
SAITO Akiko 東京大学, 大学院工学系研究科, 学術支援員
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2014: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | カンチレバ－半導体複合型バイオセンサ / 受精卵質量測定 / ピエゾ抵抗カンチレバ / Siナノワイヤバイオセンサ / 検査・診断システム / モニタリング / 医用システム / 電子デバイス・機器 |
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| Outline of Final Research Achievements |
In this research, a multi-sensing mass-sensor using piezoresistive cantilever with semiconductor sensor was investigated to measure the mass and respiration activity of a fertilized egg for non-invasive quality evaluation of in-vitro fertilized egg. We fabricated a holder-type piezoresistive cantilever using focused ion beam processing to place a single fertilized egg on the cantilever. Then, we measured a single mouse fertilized egg and sea urchin egg mass by a resonance frequency detection method and deflection detection method using the holder-type cantilever. To verify the fertilized egg mass, we measured the mass and density of a mouse fertilized egg and non-fertilized egg using a sedimentation measurement method. We also developed a Si nanowire sensor, and we demonstrated to detect a low-concentration biomolecules for respiration activity measurement of the fertilized egg.
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