Search for new biomarker of anti-cancer drug effect using near-infrared diffuse optical spectroscopy targeting vasculature and hypoxia
| Project/Area Number |
26282144
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
芳澤 暢子 浜松医科大学, 医学部附属病院, 助教 (10402314)
上田 重人 埼玉医科大学, 医学部, 助教 (20646947)
佐伯 俊昭 埼玉医科大学, 医学部, 教授 (50201512)
小倉 廣之 浜松医科大学, 医学部, 助教 (50402285)
久慈 一英 埼玉医科大学, 医学部, 教授 (90283142)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMASHITA Yutaka 浜松ホトニクス株式会社, 中央研究所, 研究主幹(理事) (80393982)
UEDA Yukio 浜松ホトニクス株式会社, 中央研究所・第7研究室, 副研究室長 (30393987)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | 画像診断システム / 拡散光イメージング / 乳がん / 乳癌 |
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| Outline of Final Research Achievements |
Diffuse optical spectroscopy is used for evaluation of tumor blood volume quantified by tissue hemoglobin concentrations. We investigated whether early changes in tumor total hemoglobin concentration predict a pathological complete response (pCR) to neoadjuvant chemotherapy in patients with operable breast cancer, and we compared the predictive value of pCR between optical spectroscopy and FDG-PET. Although changes in tumor hemoglobin concentration predicted pCR to chemotherapy with moderate accuracy, the diagnostic performance of optical spectroscopy was not superior to that of metabolic response monitored by FDG-PET.
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Report
(5 results)
Research Products
(30 results)
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[Journal Article] Near-Infrared Diffuse Optical Imaging for Early Prediction of Breast Cancer Response to Neoadjuvant Chemotherapy: A Comparative Study Using 18F-FDG PET/CT.2016
Author(s)
Ueda S, Yoshizawa N, Shigekawa T, Takeuchi H, Ogura H, Osaki A, Saeki T, Ueda Y, Yamane T, Kuji I, Sakahara H.
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Journal Title
J Nucl Med
Volume: 57
Issue: 8
Pages: 1189-1195
DOI
Related Report
Peer Reviewed
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[Presentation] Development of time-resolved reflectance diffuse optical tomography for breast cancer monitoring.2017
Author(s)
Yoshimoto K, Ohmae E, Yamashita D, Suzuki H, Homma S, Mimura T, Wada H, Suzuki T, Yoshizawa N, Nasu H, Ogura H, Sakahara H, Yamashita Y, Ueda Y.
Organizer
SPIE Photonics West 2017
Place of Presentation
San Francisco, CA, USA
Year and Date
2017-01-28
Related Report
Int'l Joint Research
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[Presentation] Change in tumor hemoglobin concentration during neoadjuvant chemotherapy may predict pathological response in ER-negative breast cancer, but not in ER-positive breast cancer.2017
Author(s)
Ueda S, Yoshizawa N, Shigekawa T, Takeuchi H, Ogura H, Osaki A, Saeki T, Ueda Y, Yamane T, Kuji I, Sakahara H.
Organizer
SPIE Photonics West 2017
Place of Presentation
San Francisco, CA, USA
Year and Date
2017-01-28
Related Report
Int'l Joint Research
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[Presentation] Near-infrared diffuse optical imaging for early prediction to neoadjuvant chemotherapy in patients with primary breast cancer2015
Author(s)
Ogura H, Yoshizawa N, Ueda S, Hosokawa Y, Matsunuma R, Tochikubo J, Nasu H, Shigekawa T, Takeuchi H, Osaki A, Saeki T, Yoshimoto K, Ohmae E, Suzuki T, Ueda Y, Yamashita Y, Sakahara H
Organizer
38th Annual San Antonio Breast Cancer Symposium
Place of Presentation
San Antonio, Texas, USA
Year and Date
2015-12-08
Related Report
Int'l Joint Research
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