| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Outline of Final Research Achievements |
Due to an aging population and the increasingly westernized diet of Japanese people, it will be essential to combat the increasing incidence of associated lifestyle-related diseases such as atherosclerosis and type 2 diabetes. For example, it is well known that atherosclerosis produces narrowing of blood vessels in the leg, which may lead to severe symptoms including gangrene. For the medical treatment of impeded blood flow (e.g. arteriosclerosis obliterans, Buerger's disease) both drug treatment and/or invasive surgical interventions （stenting, bypass graft surgery, etc.） are required.
Therefore, the aim of the present research project is to establish a novel non-invasive therapy for siRNA-induced vasculogenesis by the use of nano-size drug delivery systems, which is designed to stimulate the collateral circulation in compromised tissues. This technique will also be applicable in organ transplant and regenerative medicine.
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