Development of a minimal invasive high intensity focused ultrasound system for intrauterine fetal therapy

• Project/Area Number: 26282150
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Medical systems
• Research Institution: Nihon University (2015-2016); National Research Institute for Child Health and Development (2014)
• Principal Investigator: YAMASHITA Hiromasa 日本大学, 総合科学研究所, 准教授 (00470005)
• Co-Investigator(Kenkyū-buntansha): 梅村 晋一郎 東北大学, その他の研究科, 教授 (20402787) ; 宮本 義孝 国立研究開発法人国立成育医療研究センター, その他部局等, 研究員 (20425705) ; 土岐 彰 昭和大学, 医学部, 教授 (50163960) ; 千葉 敏雄 日本大学, 総合科学研究所, 教授 (20171944) ; 杉山 彰英 昭和大学, 医学部, 講師 (10349087)
• Research Collaborator: SOBHAN Ubaidus ; MOCHIZUKI Takashi ; OSAWA Shunsuke ; ANDO Shinsuke
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000); Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2014: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
• Keywords: 集束超音波 / 医療・福祉 / 胎児治療 / 超音波画像

Outline of Final Research Achievements

This study aims development of basic technologies for medical application of the high intensity focused ultrasound (HIFU) for minimal invasive before-birth fetal therapy, especially for therapy of congenital diaphragmatic hernia. We invented a new method to release a balloon, in fetal trachea by easy delivery of HIFU. We confirmed that balloon was inflated by nano-droplet or micro-capsuled limonene and wall of the balloon was broken or perforated only by HIFU-delivery with high probability in phantom and in vitro animal experiments.

Research Products

• [Journal Article] Non-touch quick destruction of the tracheal occluding balloon using HIFU (2017)
  • Author(s): Shunsuke Osawa, Tomoo Sato, Hiromasa Yamashita, Takashi Mochizuki, Gontaro Kitazumi, Jacques Jani, Akira Toki, Toshio Chiba
  • Journal Title: The Showa University Journal of Medical Sciences Volume: 印刷中
  • NAID: 130005865027
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] An emerging means of balloon disruption after fetal tracheal occlusion: high intensity focused ultrasound (2016)
  • Author(s): Shinsuke Ando, Shunsuke Osawa, Hiromasa Yamashita, Ubaidus Sobhan, Takashi Mochizuki, Akira Toki, Toshio Chiba
  • Organizer: 35th Annual Meeting of the International Fetal Medicine and Surgery Society (IFMSS 2016)
  • Place of Presentation: Kasane, North-West, Botswana
  • Int'l Joint Research
• [Presentation] 先天性横隔膜ヘルニアの胎児鏡下気管閉塞術における集束超音波の応用について (2016)
  • Author(s): 安藤晋介、大澤俊亮、山下紘正、ソブハン・ウバイダス、望月剛、土岐彰、千葉敏雄
  • Organizer: 第15回日本超音波治療研究会（JSTU2016）
  • Place of Presentation: 東京女子医科大学、東京都新宿区河田町、日本
• [Presentation] Application of High-intensity Focused Ultrasound in Fetal Therapy: Balloon disruption after fetal endoscopic tracheal occlusion (2015)
  • Author(s): Shunsuke Osawa, Hiromasa Yamashita, Takashi Mochizuki, Gontaro Kitazumi, Akira Toki, Jacques Jani, Toshio Chiba
  • Organizer: 14th World Congress in Fetal Medicine (FMF2015)
  • Place of Presentation: Creta Maris Beach Resort, Greece
  • Year and Date: 2015-06-23
  • Int'l Joint Research
• [Presentation] 強力集束超音波（HIFU）による胎児鏡下気管閉塞術のバルーン解除の検討２ (2014)
  • Author(s): 佐藤智夫，大澤俊亮，山下紘正，ソブハン・ウバイダス，石井理絵，望月剛，Mark I. Evans，土岐彰，千葉敏雄
  • Organizer: 第12回日本胎児治療学会学術集会
  • Place of Presentation: 久留米
  • Year and Date: 2014-11-30
• [Presentation] Semi Real-time Monitoring of Ultrasound Balloon Rupture for Fetal Surgery (2014)
  • Author(s): Tomoo Sato, Shunsuke Osawa, Hiromasa Yamashita, Sobhan Ubaidus, Rie Ishii, Takashi Mochizuki, Shin Yoshizawa, Shin-ichiro Umemura, Toshio Chiba
  • Organizer: 生体医工学シンポジウム2014
  • Place of Presentation: 東京
  • Year and Date: 2014-09-26
• [Presentation] A Mechanism of Ultrasound Balloon Rupture for Fetal Surgery (2014)
  • Author(s): Tomoo Sato, Shunsuke Osawa, Hiromasa Yamashita, Hiroshi Ohtake, Jun Yonai, Hiroyasu Sasaki, Takashi Mochizuki, Toshio Chiba
  • Organizer: 2014 IEEE International Ultrasonics Symposium
  • Place of Presentation: Chicago, Illinois USA
  • Year and Date: 2014-09-06
• [Presentation] Balloon Disruption Using High-intensity Focused Ultrasound: Evolving modality to be combined with fetal endoscopic tracheal occlusion (2014)
  • Author(s): Shunsuke Osawa, Hiromasa Yamashita, Tomoo Sato, Takashi Mochizuki, Gontaro Kitazumi, Akira Toki, Toshio Chiba
  • Organizer: 13th World Congress in Fetal Medicine (FMF2014)
  • Place of Presentation: Nice, France
  • Year and Date: 2014-06-29 – 2014-07-03
• [Presentation] Fetus as a prospective pediatric patient (2014)
  • Author(s): T. Chiba, H. Yamashita, S. Osawa, T. Sato, R. Ishii, S. Ubaidus, A. Toki
  • Organizer: Computer Assisted Radiology and Surgery 28th International Congress and Exhibition (CARS2014)
  • Place of Presentation: 福岡
  • Year and Date: 2014-06-26
• [Patent(Industrial Property Rights)] 医療用超音波システム及び医療用超音波装置 (2016)
  • Inventor(s): 千葉敏雄、山下紘正、丸山一雄、鈴木亮、望月剛
  • Industrial Property Rights Holder: 日本大学、帝京大学、MU研究所
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-126601
  • Filing Date: 2016-06-27